scholarly journals Controlled Release of Bi-Layered EGCG Tablets Using 3D Printing Techniques

2021 ◽  
pp. 5-13
Author(s):  
Satish Kumar Sharma ◽  
Pankaj Bhatt
Keyword(s):  
Mechanical Properties ◽  
Controlled Release ◽  
3D Printing ◽  
Sustained Release ◽  
Epigallocatechin Gallate ◽  
Physical And Mechanical Properties ◽  
Immediate Release ◽  
3D Printer ◽  
Weight Variation ◽  
Cost Efficient

Epigallo-catechin Gallate (or EGCG) is a polyphenol which is withdrawn from green tea and is commercially available as Epigallocatechin gallate. Epigallo-catechin gallate is known to have been used as dye and food colorants, but it also has many medicinal properties like anti-inflammatory, anti-microbial, anti-diabetic, anti-obesity, and anti-cancer. Keeping these medical properties in mind, in the present research paper, a 3D printing technique evolving a desktop based 3D printer to extrude tablets along with the active drug ingredient and other excipients that are used as binders and disintegrants. The method adapted in the formulation of a3D printed tablet in this research makes the tablet suitable for immediate and sustained release and does not affects it’s certain physical and mechanical properties such as hardness, friability, and weight variation. The tablets which are extruded from the 3D printer are the bi-layer tablets with controlled release. With the involvement of the 3D printer, the cost of printing the bi-layered tablets have found to be very low which makes the method cost efficient. The output bi-layer tablet has been developed using various analysis and specified standard apparatus and method so that the set standards of the tablet does not get affected. The immediate release and the sustained release methods were studied separately. The final stage of the research completes when the 3D printed tablets with set time intervals for the initial and sustained release and without changing the set mechanical properties of the tablet are obtained.

Controlled Release of Bi-Layered Malvidin Tablets Using 3D Printing Techniques

2021 ◽  
pp. 70-78
Author(s):  
Tejinder Kaur ◽  
Suruchi Singh
Keyword(s):  
Controlled Release ◽  
3D Printing ◽  
Fruits And Vegetables ◽  
Physical And Mechanical Properties ◽  
3D Printer ◽  
Anti Cancer ◽  
Printing Cost ◽  
3D Printed ◽  
Cost Efficient ◽  
3D Printing Technique

Malvidin belongs to the class of anthocyanidin, a pigment compound present in fruits and vegetables like the colored berries, flowers, and vegetables which have pigments on it and it is available commercially as malvidin chloride. Malvidin is known to possess many medicinal characteristics like anti-microbial, anti-diabetic, anti-inflammatory, anti-obesity, and anti-cancer. In this research paper, a 3D printing technique is used which evolves a 3D printer based on desktop that extrudes tablets comprising the active drug which here is malvidin our main ingredient and the other excipients which are used as binders and disintegrants. Methods which are adapted here for the formulation of 3D printed tablet make the tablets appropriate for immediate and sustained release with its definite physical and mechanical properties like hardness, friability, and weight. Tablets that are extruded by the 3D printer are controlled release bi-layer tablets. Due to involvement of 3D printer, printing cost for the bi-layered tablets found very low that makes our method as cost efficient.

scholarly journals Controlled Release of Bi-Layered Delphinidin Tablets Using 3D Printing Techniques

2020 ◽  
pp. 73-81
Author(s):  
Tejinder Kaur ◽  
Satish Kumar Sharma
Keyword(s):  
Controlled Release ◽  
3D Printing ◽  
Sustained Release ◽  
Immediate Release ◽  
Drug Formulation ◽  
3D Printer ◽  
Anti Cancer ◽  
Pharmaceutical Industries ◽  
Medicinal Properties ◽  
Printing Techniques

Delphinidin is a known dye and food colorant along with many medicinal properties for instance anti-inflammatory, anti-microbial, anti-diabetic, anti-obesity and anti-cancer. The present research has been designed to formulate bi-layered tablets using delphinidin which inherits these medicinal properties. The extrusion of tablets is done by using 3D printing techniques involving a table-top 3D printer which extrudes delphinidin tablets along with the required excipients. The characteristics of the whole tablets have been analyzed separately including hardness, friability, and weight. Adapted method for tablet formulation results in tablets which are appropriate for the immediate release and sustained release. The present research provides a method to make the effective tablets with reduced cost which can be used as drug formulation method in pharmaceutical industries.

APPLICATION OF ADDITIVE TECHNOLOGIES IN THE TECHNICAL SERVICE OF GARDEN EQUIPMENT

2020 ◽  
pp. 39-44
Author(s):  
ALEKSEI S. DOROKHOV ◽  
◽  
ALEKSEI S. SVIRIDOV ◽  
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Physical And Mechanical Properties ◽  
Additive Technologies ◽  
3D Printer ◽  
Technical Service ◽  
Test Results ◽  
Standard Samples ◽  
Sliding Bearings ◽  
Equipment Failures

The paper considers the analysis of the market for garden equipment. The authors consider some information on garden equipment failures, using an example of Husqvarna trimmers. They also assess a possibility of using additive technologies to manufacture sliding bearings for mechanical drives of garden equipment. For testing the physical and mechanical properties, a batch of samples was prepared by means of 3D printing using FDM (FFF) technology. According to the ASTM D638-14 standard, samples were prepared on a PICASO 3D Desingner X Pro 3D printer. Samples were made of ABS-plastic and PA12 with diff erent degrees of fi lling: 20, 50 and 100%. It is noted that the destruction pattern of samples made of diff erent materials is signifi cantly diff erent. Samples made from ABS plastics are more fragile than samples made from PA12. According to the test results, PA12 with 100% fi lling have shown the best results, which makes them suitable for use in the manufacture of slide bearings by means of 3D printing.

scholarly journals Investigation of the physical and mechanical properties of composite materials obtained using additive technologies

2021 ◽  
pp. 9-21
Author(s):  
Vladyslav Solovei ◽  
Vitalii Oleksyshen V.
Keyword(s):  
Mechanical Properties ◽  
Composite Materials ◽  
3D Printing ◽  
Physical And Mechanical Properties ◽  
Additive Technologies ◽  
Polymer Matrices ◽  
3D Printer ◽  
Reinforcing Fillers ◽  
Reinforcing Fibers ◽  
The Creation

The prevalence of polymers in all spheres of human life necessitates the creation of new more effective composite materials based on polymer matrices and reinforcing fillers, which by their characteristics meet the growing needs of society. In modern industry, production speeds are constantly increasing, so additive technologies are becoming a powerful alternative to traditional single and small-scale production. Among the existing types of additive technologies, the method of fused deposition modeling (FDM) deserves special attention, which provides an opportunity to organize production in conditions of limited material, time and human resources. As opposite to traditional production technologies, such as injection molding, FDM allows you to create products of more complex geometric shapes, using different combinations of polymer matrices and reinforcing fillers and thus create composite materials with the required physico-mechanical, rheological and other properties. At the same time, the main advantages of FDM also cause a number of serious disadvantages, such as anisotropy of the properties of finished products, printing defects that lead to increased yields of defective products, uneven physical and mechanical properties etc. In particular, the anisotropy of the properties of FDM-printed products results in significantly lower strength of the parts in the transverse direction to the 3D printing direction (strand overlay direction) compared to the longitudinal one, and the discontinuity of the reinforcing fibers in the strands of polymeric material leads to reduced strength. The main areas of research to modernize the process of manufacturing products on a 3D printer using the FDM method are: modernization of components and structures of 3D printers to improve the melting process and layering of materials, aimed at improving print quality and speed, as well as reducing defective yield products; improving the properties of raw materials and creating composite materials to improve the quality of finished products and their characteristics, such as electrical, chemical, mechanical, thermal, environmental, etc .; development of new biopolymers, technologies of their production and use for 3D-printing, which in the future are planned to be used in the creation of bionic parts of human bodies, etc. To overcome the main shortcomings of FDM technology, it is proposed to modernize the method of 3D printing and the extruder unit of the 3D printer, which allows to create composite materials directly (directly in the extruder), using different combinations of polymer matrices and solid reinforcing fibers.

scholarly journals DEVELOPMENT AND EVALUATION OF BILAYER TABLETS FOR IMMEDIATE AND CONTROLLED RELEASE OF METFORMIN HYDROCHLORIDE

2017 ◽  
pp. 173-179
Author(s):  
Rablee Saikia ◽  
Bhanu Pratap Sahu
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Effective Treatment ◽  
In Vitro Release ◽  
Immediate Release ◽  
Metformin Hydrochloride ◽  
Wet Granulation ◽  
Time Interval ◽  
Weight Variation

Objective: The purpose of this study was to develop and evaluate bi-layer tablets for the immediate and controlled release of Metformin Hydrochloride for effective treatment of type 2 Diabetes mellitus.Methods: The immediate release layer was prepared by using super disintegrants like cross carmellose sodium, sodium starch glycolate and sustained release layer was prepared by using hydrophilic polymer like HPMC K 100 and PVP. Various proportions of super disintegrants and polymer were used to select the best formulation composition. Bilayer tablet of metformin was prepared by wet granulation method and was evaluated for physical characteristics like hardness, weight variation, and friability. In vitro release of drug was performed in USP type II dissolution test apparatus using phosphate buffer (pH 6.8) as dissolution media and dissolution was continued for 9 h for the sustained release layer. For immediate release layer, readings were recorded in each 10 min time interval for the first 1h.Results: From the obtained result it was found that all the formulations were within the limit of the standard. The hardness was found to be in the ranges from 5.1 to 5.5 kg/cm2, weight variation was in the range 0.53% to 0.83%, friability of all the formulations was within the range (<1%)and percentage of drug content was more than 97%. The drug release of the tablet was in the range of 85%-91% in 9 h.Conclusion: From the result obtained, it is found that the formulation F6 satisfies all the criteria as sustained release tablet for the effective treatment of type 2Diabetes mellitus.  

scholarly journals DEVELOPMENT OF BILAYER TABLETS FOR IMMEDIATE AND CONTROLLED RELEASE OF ALLICIN

2017 ◽  
Vol 9 (4) ◽  
pp. 153
Author(s):  
Manoj Kr. Das ◽  
Bhanu P. Sahu ◽  
Jahan Nur Rahman Hazarika
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Effective Treatment ◽  
In Vitro Release ◽  
Immediate Release ◽  
Optimum Result ◽  
Bilayer Tablet ◽  
Weight Variation ◽  
Formulation Parameters

Objective: The purpose of this study was to develop and evaluate bilayer tablet for the immediate and controlled release of Allicin (Garlic Extract) for effective treatment of Hypertension.Methods: The immediate release layer was prepared by using super disintegrants-sodium starch glycolate and binder used xantham gum and the sustained release layer was prepared by using hydrophilic polymer like HPMC K 100 and PVP. Before preparation of the tablets, all the pre-formulation parameters were checked and the tablet of Allicin were prepared by direct compression method and was evaluated for physical characteristics like hardness, weight variation, drug content and friability. In vitro release of drug was performed USP type II dissolution test apparatus using phosphate buffer (pH 7.4) as dissolution media and dissolution was continued for 8 hrs for the sustained release layer.Results: It was found that all the formulations were within the limit of the standard. The drug release of the tablet was in the range of 66%-83% in 8 h.Conclusion: It was concluded that the F4 formulation showed the optimum result as a bilayer tablet for the effective treatment of hypertension. 

scholarly journals Mechanical properties of structures produced by 3D printing from composite materials

2019 ◽  
Vol 254 ◽  
pp. 01018
Author(s):  
František Bárnik ◽  
Milan Vaško ◽  
Milan Sága ◽  
Marián Handrik ◽  
Alžbeta Sapietová
Keyword(s):  
Mechanical Properties ◽  
Composite Materials ◽  
3D Printing ◽  
Carbon Fibers ◽  
3D Printer

By 3D printing it is possible to create different structures with different fiber-laying directions. These structures can be created depending on the type of 3D printer and its software. The Mark Two printer allows printing Onyx, a material based on nylon in combination with microcarbon fibers. Onyx can be used alone or reinforced with kevlar, glass or carbon fibers. This article deals with 3D printing and evaluation of mechanical properties of printed samples.

A physical investigation of dimensional and mechanical characteristics of 3D printed nut and bolt for industrial applications

2022 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Ramesh Chand ◽  
Vishal S. Sharma ◽  
Rajeev Trehan ◽  
Munish Kumar Gupta
Keyword(s):  
Mechanical Properties ◽  
Shear Strength ◽  
3D Printing ◽  
Surface Properties ◽  
3D Printer ◽  
Content Type ◽  
Safety Issues ◽  
Machine Failure ◽  
Sharp Edges ◽  
3D Printed

Purpose A nut bolt joint is a primary device that connects mechanical components. The vibrations cause bolted joints to self-loosen. Created by motors and engines, leading to machine failure, and there may be severe safety issues. All the safety issues and self-loosen are directly and indirectly the functions of the accuracy and precision of the fabricated nut and bolt. Recent advancements in three-dimensional (3D) printing technologies now allow for the production of intricate components. These may be used technologies such as 3D printed bolts to create fasteners. This paper aims to investigate dimensional precision, surface properties, mechanical properties and scanning electron microscope (SEM) of the component fabricated using a multi-jet 3D printer. Design/methodology/approach Multi-jet-based 3D printed nut-bolt is evaluated in this paper. More specifically, liquid polymer-based nut-bolt is fabricated in sections 1, 2 and 3 of the base plate. Five nuts and bolts are fabricated in these three sections. Findings Dimensional inquiry (bolt dimension, general dimensions’ density and surface roughness) and mechanical testing (shear strength of nut and bolt) were carried out throughout the study. According to the ISO 2768 requirements for the General Tolerances Grade, the nut and bolt’s dimensional examination (variation in bolt dimension, general dimensions) is within the tolerance grades. As a result, the multi-jet 3D printing (MJP)-based 3D printer described above may be used for commercial production. In terms of mechanical qualities, when the component placement moves from Sections 1 to 3, the density of the manufactured part decreases by 0.292% (percent) and the shear strength of the nut and bolt decreases by 30%. According to the SEM examination, the density of the River markings, sharp edges, holes and sharp edges increased from Sections 1 to 3, which supports the findings mentioned above. Originality/value Hence, this work enlightens the aspects causing time lag during the 3D printing in MJP. It causes variation in the dimensional deviation, surface properties and mechanical properties of the fabricated part, which needs to be explored.

scholarly journals Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets

2015 ◽  
Vol 18 (2) ◽  
pp. 157-162
Author(s):  
Samira Karim ◽  
Mohiuddin Ahmed Bhuiyan ◽  
Md Sohel Rana
Keyword(s):  
Sustained Release ◽  
Immediate Release ◽  
Pharmaceutical Journal ◽  
In Vitro Dissolution ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Zero Order Kinetics ◽  
Weight Variation ◽  
Sustained Release Tablets

This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected to various physical parameter tests including weight variation, friability, hardness, thickness, diameter, etc. In vitro dissolution studies of the formulations were done at pH 6.8 in phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm. The percent releases of all the formulations (30) were 73.11%- 98.76% after 8 hours. The release pattern followed zero order kinetics and the release of the drug was hindered by the polymers used in the study. On the other hand, 100% drug was released within 1 hour from the immediate release tablet of glimepiride. The study reveals that the polymers used have the capacity to retard the release of the drug from the sustained release tablets and the more is the amount of the polymer in the formulation the less is the release of drug showing more retardation of drug release.Bangladesh Pharmaceutical Journal 18(2): 157-162, 2015

scholarly journals Mechanical and physical properties of fine-grained concrete for concrete additive manufacturing

2019 ◽  
Vol 91 ◽  
pp. 02041
Author(s):  
Sergey Udodov ◽  
Yuriy Galkin ◽  
Philip Belov
Keyword(s):  
Mechanical Properties ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Physical Properties ◽  
Crucial Role ◽  
Physical And Mechanical Properties ◽  
Concrete Composition ◽  
Fine Grained ◽  
Mechanical And Physical Properties ◽  
Time Periods

Additive manufacturing (3D printing) is becoming more and more common in the field of modern construction. However, for wider implementation of this technology, it is necessary to solve a number of material-oriented scientific problems related to development of concrete composition with targeted rheological, stress-strain, physical and mechanical properties. It has been established that time periods between successful applications of layers play the crucial role in ensuring monolithic features of the “printed” structures. Application of mathematics planning of the experiment allowed establishing the main principles of formation of basic physical and mechanical properties of fine-grained concrete depending on material composition.

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