scholarly journals Role of Pentraxin-3 in Periodontal Inflammation - A Comprehensive Review

2021 ◽  
pp. 209-219
Author(s):  
Syed Wali Peeran ◽  
Ahmed Elhassan ◽  
Tazeen Dawood ◽  
Karthikeyan Ramalingam ◽  
Syed Ali Peeran ◽  
...  
Keyword(s):  
Acute Phase ◽  
Tissue Injury ◽  
Fluid Phase ◽  
Pentraxin 3 ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Periodontal Inflammation ◽  
Potential Biomarker ◽  
Inflammatory Site

Acute phase reactants like C-reactive protein (CRP), and pentraxin 3 (PTX3) are increased with inflammation and tissue injury. PTX3 is an acute phase protein and a member of the long pentraxin family. CRP is synthesized in the liver but PTX3 is generated locally at the inflammatory site. It is a fluid-phase pattern-recognition molecule that regulates antimicrobial immunity and inflammation by interfering with selectin-dependent neutrophil recruitment and regulating the complement cascade. Hence, PTX3 could be used as a potential biomarker to identify inflammatory response in both acute and chronic diseases. In this review, we discuss the role of PTX3 in periodontal inflammation.

One more health benefit of blood donation: reduces acute-phase reactants, oxidants and increases antioxidant capacity

2016 ◽  
Vol 27 (6) ◽  
Author(s):  
Muharrem Yunce ◽  
Husamettin Erdamar ◽  
Nezihe Asli Bayram ◽  
Sumeyye Gok
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Acute Phase ◽  
Blood Donation ◽  
Health Benefit ◽  
Oxidative Status ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein

AbstractBackground:One of the most important problems in finding blood donors is the inadequacy of volunteer number. To overcome this problem, one of the solutions we suggest is innovating new health benefits of blood donation. The aim of the present study is to investigate the effects of blood donation on oxidative status markers and acute-phase reactants.Methods:A total of 96 healthy volunteers were recruited into the study. Blood samples were withdrawn 5 min before and 24 h after the blood donation. Serum nitric oxide, malondialdehyde levels, and activity of superoxide dismutase and myeloperoxidase were measured spectrophotometrically. Serum levels of high-sensitive C-reactive protein and pentraxin-3 as acute-phase reactants were measured by enzyme-linked immunosorbent assay kits.Results:We found statistically significant lower pentraxin-3 and high-sensitive C-reactive protein levels and higher superoxide dismutase activity and nitric oxide level 24 h after blood donation in serum of blood donor when compared with before blood donation.Conclusions:These findings suggest that blood donation affected oxidative status and acute-phase reactants in donors. Blood donation removes oxidants and decreases oxidative stress by elevating antioxidant enzyme such as superoxide dismutase. This is one more health benefit or reason why we should donate blood. Further large-scale studies should evaluate this mechanism and compare the same effect of wet cupping therapy.

scholarly journals The Variation of Pentraxin-3 in Febrile Patients Admitted With or Without Convulsions

2021 ◽  
Author(s):  
Şefika Bardak ◽  
Mine Cinbis ◽  
Yaşar Enli
Keyword(s):  
Blood Cell ◽  
Patient Group ◽  
Acute Phase ◽  
White Blood Cell ◽  
Pediatric Emergency ◽  
Control Group ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein

Objective: Febrile convulsions are the most frequent seizures in childhood. Pentraxin-3 is a new generation acute phase reactant that belongs to the family of long pentraxins. In our study, our primary aim was to investigate the difference in serum Pentraxin-3 levels between febrile convulsive patient group and non-convulsive fever control group. Our secondary aim was to evaluate the correlation between serum Pentraxin-3 levels and other more frequently used acute phase reactants (C-reactive protein, white blood cell count). Methods: Patients admitted to the pediatric emergency department between January 2014 and July 2014 were included in this prospective study The study included 35 febrile convulsive patients (patient group) and 35 non-convulsive febrile patients (control group) with similar age and gender, without chronic disease or ongoing medication brought to a university hospital Pediatric Emergency Department. Anamnesis information including active complaints, self and family history and laboratory findings of all cases included in the study were recorded on previously printed forms with demographic information such as age (month) and gender of the patient. In statistical analysis, the significance level was accepted as p <0,05. Results: There was no statistically significant difference between the groups in terms of age, gender, serum urea, creatinine, electrolytes, C-reactive protein and white blood cell counts (p>0,05). Serum Pentraxin-3 levels were 4,8±2,5 ng/ml in the patient group and 4.1±2.3 ng/ml in the control group. The difference between the two groups was not statistically significant (p>0,05). No correlation was found between Pentraxin-3 with C-reactive protein and white blood cell count. Conclusion: Our findings show that serum Pentraxine-3 levels are similar in patients with febrile convulsion and fever. In addition, it was concluded that Pentraxine-3 does not correlate with acute phase reactants, which are more commonly used.

scholarly journals Pentraxin 3: A Novel Biomarker for Inflammatory Cardiovascular Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Kenji Inoue ◽  
Tatsuhiko Kodama ◽  
Hiroyuki Daida
Keyword(s):  
Gene Expression ◽  
Cardiovascular Disease ◽  
Pentraxin 3 ◽  
Human Endothelial Cells ◽  
C Reactive Protein ◽  
Physiological Concentration ◽  
Reactive Protein ◽  
Atherosclerotic Lesions ◽  
Human Genes

Numerous studies have recently examined the role of pentraxin 3 (PTX3) in clinical situations. The pentraxin family includes C-reactive protein (CRP); however, unlike CRP, PTX3 is expressed predominantly in atherosclerotic lesions that involve macrophages, neutrophils, dendritic cells, or smooth muscle cells. Interestingly, PTX3 gene expression in human endothelial cells is suppressed to a greater extent by pitavastatin than the expression of 6,000 other human genes that have been examined, suggesting that PTX3 may be a novel biomarker for inflammatory cardiovascular disease. The expression and involvement of PTX3 in cardiovascular diseases are discussed in this paper, along with the characteristics of PTX3 that make it a suitable biomarker; namely, that the physiological concentration is known and it is independent of other risk factors. The results discussed in this paper suggest that further investigations into the potential novel use of PTX3 as a biomarker for inflammatory cardiovascular disease should be undertaken.

scholarly journals Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians

2015 ◽  
Vol 2 (3) ◽  
Author(s):  
Anurag Markanday
Keyword(s):  
Acute Phase ◽  
English Language ◽  
Biological Marker ◽  
Acute Phase Reactants ◽  
Medline Search ◽  
Reactive Protein ◽  
Guidance Strategies ◽  
Published Evidence ◽  
Meta Analyses

Abstract Acute-phase reactants such as erythrocyte sedimentation rate and C-reactive protein have traditionally been used as markers for inflammation and as a measure of “sickness index” in infectious and noninfectious conditions. In the last decade, more data have become available on the wider and more specific role for these markers in the management of complex infections. This includes the potential role in early diagnosis, in differentiating infectious from noninfectious causes, as a prognostic marker, and in antibiotic guidance strategies. A better defined role for biological markers as a supplement to clinical assessment may lead to more judicious antibiotic prescriptions, and it has the potential for a long-term favorable impact on antimicrobial stewardship and antibiotic resistance. Procalcitonin as a biological marker has been of particular interest in this regard. This review examines the current published evidence and summarizes the role of various acute-phase markers in infections. A MEDLINE search of English-language articles on acute-phase reactants and infections published between 1986 and March 2015 was conducted. Additional articles were also identified through a search of references from the retrieved articles, published guidelines, systematic reviews, and meta-analyses.

scholarly journals Dynamics of inflammatory factors expression in ischemic brain tissue injury

2019 ◽  
Vol 11 (4) ◽  
Author(s):  
Tonko Marinović ◽  
Silvio Bašić ◽  
Dominik Romić ◽  
Branimir Nevajda ◽  
Lovorka Đerek ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Tissue Injury ◽  
Interleukin 10 ◽  
Inflammatory Factors ◽  
Modern World ◽  
C Reactive Protein ◽  
High Association ◽  
Reactive Protein ◽  
Initial Onset

Ischemic stroke is one of the most common cause of mortality and disability in the modern world. Still, therapeutic options remains modest. Aim of the study was to present dynamics of inflammatory factors expression (C reactive protein, procalcitonin, interleukin 10) in patients after ischemic stroke. Our study included 101 patients divided in thrombolised and non-thrombolised groups. Inflammatory factors concentration in serum was determinate at admission, 24, 48 hours and seven days after the initial onset, while neurological assessment was measured at the admission, 24 hours, seven days and three months after the initial onset using National Institute of Health Stroke Scale and Rankin Scale. Certain pattern was observed in dynamics of inflammatory factors: intensive increase in first and second day after the stroke, followed by decrease till day seven in both groups. Additionally, thrombolised group showed significant neurological improvement. Although well investigated, the role of inflammatory factors in the ischemic stroke still stays controversial. High association of C reactive protein and interleukin 10 values suggest potential prognostic role in patients follow-up, while the role of procalcitonin values still remains unclear.

scholarly journals Combined C-Reactive Protein and Novel Inflammatory Parameters as a Predictor in Cancer—What Can We Learn from the Hematological Experience?

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1966 ◽  
Author(s):  
Øystein Bruserud ◽  
Helene Hersvik Aarstad ◽  
Tor Henrik Anderson Tvedt
Keyword(s):  
Acute Phase ◽  
Hematological Malignancies ◽  
Phase Reaction ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

The acute phase reaction is a systemic response to acute or chronic inflammation. The serum level of C-reactive protein (CRP) is the only acute phase biomarker widely used in routine clinical practice, including its uses for prognostics and therapy monitoring in cancer patients. Although Interleukin 6 (IL6) is a main trigger of the acute phase reactions, a series of acute phase reactants can contribute (e.g., other members in IL6 family or IL1 subfamily, and tumor necrosis factor α). However, the experience from patients receiving intensive chemotherapy for hematological malignancies has shown that, besides CRP, other biomarkers (e.g., cytokines, soluble cytokine receptors, soluble adhesion molecules) also have altered systemic levels as a part of the acute phase reaction in these immunocompromised patients. Furthermore, CRP and white blood cell counts can serve as a dual prognostic predictor in solid tumors and hematological malignancies. Recent studies also suggest that biomarker profiles as well as alternative inflammatory mediators should be further developed to optimize the predictive utility in cancer patients. Finally, the experience from allogeneic stem cell transplantation suggests that selected acute phase reactants together with specific markers of organ damages are useful for predicting or diagnosing graft versus host disease. Acute phase proteins may also be useful to identify patients (at risk of) developing severe immune-mediated toxicity after anticancer immunotherapy. To conclude, future studies of acute phase predictors in human malignancies should not only investigate the conventional inflammatory mediators (e.g., CRP, white blood cell counts) but also combinations of novel inflammatory parameters with specific markers of organ damages.

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