scholarly journals An Association between COVID-19 and Diabetes Mellitus

2021 ◽  
pp. 103-111
Author(s):  
Aaditi Bansod ◽  
Ashish Anjankar
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Surgical Removal ◽  
Extreme Risk ◽  
Wide Range ◽  
Fungicidal Treatment ◽  
Hypoglycaemic Agent ◽  
Insulin Dependent ◽  
To Come

Coronaviruses are a large group of viruses accountable for initiating severe acute respiratory syndrome  (SARS), Middle East Respiratory Syndrome (MERS), Common Cold, etc. Studies have found a certainly available development severity about covid epidemic over rising in blood glucose level sufferers. There is the effect of functioning dextrose equilibrium, rawness, change-resistant level together with a start regarding this peptide-aldosterone method (RAAS) caused by possible infective connection in the middle of  SARS-CoV-2 along with insulin-dependent diabetes. Your chance regarding come to have extremely unwell against SARS-CoV-2 live probable via occurring minor whether you all are blood glucose level crop up controlled. Experience coronary illness either more difficulty over inclusion on rising in blood glucose level would intensify this likeliness on obtaining solemnly sick by SARS-CoV-2, similar to another fervid contamination, on account of additional compared to only situation build that solid as you all are physique directed toward opposing this contamination. Growing contamination would too expand swelling, either inner bump, rising humans accompanied by a rise in blood glucose level, above-target blood sugars can also be the cause of that, and more severe complications can happen due to that inflammation. Instead of the other side, recently developed rise in glucose blood level and extreme catabolic difficulties regarding the previous rise in blood glucose level, as well as ketoacidosis diabetic including non-ketotic hyperglycemia considering whichever unusually excessive shots regarding hypoglycaemic agent come about validate, turned out to be seen within sufferer of SARS-CoV-2. In Hindustan throughout this, another upsurge regarding this SARS-CoV-2, seeing that unparalleled gush over patient regarding black fungus took place were seen: resistance down-regulation give rise to Covid-19 along with this utilization regarding effective against a wide range of organisms along with glucocorticoids-specific convalescent which is a dully restrained rise in blood glucose level along the ketoacidosis—are to be expected be obliged to come up with up to mutiny. SARS-CoV-2 comes behind alongside black fungus shore extreme risk bloodshed rate along with opportune observation, fungicidal treatment, cruel incision, the usually surgical removal of lacerated left important element of this operation.

scholarly journals A ROLE OF AYURVEDIC MANAEGEMENT IN INSULIN DEPENDENT DIABETES MELLITUS: A CASE STUDY

2021 ◽  
Vol 9 (4) ◽  
pp. 900-903
Author(s):  
Vidhi Patel ◽  
Dhaval Dholakiya ◽  
Manish V. Patel
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Signs And Symptoms ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Lifestyle Disease

Diabetes Mellitus is one of the of the most common non communicable or lifestyle disease globally. In Ayurveda this condition can be correlate with Madhumeha. It is one type of Prameha where the patient passes honey like urine. Prevalence of diabetes mellitus is rapidly rising throughout the world, where India leads with largest num- ber of diabetes. In Ayurveda Madhumeha is explained as Asadhya but also gives treatment for it. Ayurveda can be useful in the treatment of diabetes and associated complications. Sodhan and Shaman both are useful in the treat- ment of Madhumeha. A 64 years old male patient known case of Insulin dependent diabetes mellitus was visited in OPD of P. D. Patel Ayurveda Hospital, Nadiad. He had complaints of weakness, pain in both knee joint and shoulder joint with back pain since 10 years. Patient was on regular allopathic medicine for 10 year but he did not got any satisfactory relief in the sign and symptoms. His blood glucose level also not under control. He was treated for 28 days in I.P.D. treatment then after O.P.D. treatment also given. After treatment a significant improvement was noted in patient’s signs and symptoms. His blood glucose level also under control even after insulin therapy and hypoglycemic drugs were stopped. There was 80% relief after I.P.D. and O.P.D. treatment. Keywords: Diabetes, Madhumeha, Sodhan, Shamana, Blood glucose.

scholarly journals Insulin-Loaded Barium Salt Particles Facilitate Oral Delivery of Insulin in Diabetic Rats

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 710
Author(s):  
Rahela Zaman ◽  
Md. Emranul Karim ◽  
Iekhsan Othman ◽  
Anuar Zaini ◽  
Ezharul Hoque Chowdhury
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Insulin Aspart ◽  
Oral Delivery ◽  
Diabetic Rats ◽  
Duration Of Action ◽  
Wide Range ◽  
Ft Ir

Oral delivery is considered as the most preferred and yet most challenging mode of drug administration; especially a fragile and sensitive peptide like insulin that shows extremely low bioavailability through the gastro-intestinal (GIT) route. To address this problem, we have designed a novel drug delivery system (DDS) using precipitation-induced Barium (Ba) salt particles. The DDS can load insulin molecules and transport them through the GIT route. There were several in vitro simulation tests carried out to prove the efficiency of Ba salt particles as oral delivery candidates. All three Ba salt particles (BaSO4, BaSO3, and BaCO3) showed very good loading of insulin (>70% in all formulations) and a degree of resistance throughout a wide range of pHs from basic to acidic conditions when assessed by spectrophotometry. Particles and insulin-associated particles were morphologically assessed and characterized using FE-SEM and FT-IR. A set of tests were designed and carried out with mucin to predict whether the particles are potentially capable of overcoming one of the barriers for crossing intestinal epithelium. The mucin binding experiment demonstrated 60–100% of mucin adhesion to the three different particles. FT-IR identifies the characteristic peaks for mucin protein, particles, and particle-mucin complex re-confirming mucin adhesion to the particles. Finally, the effectiveness of nano-insulin was tested on streptozotocin (STZ) induced diabetic rats. A short acting human insulin analog, insulin aspart, was loaded into Ba salt particles at a dose of 100 IU/Kg prior to oral administration. Among the three formulations, insulin aspart-loaded BaSO4 and BaCO3 particles dramatically reduced the existing hyperglycemia. BaSO4 with loaded Insulin showed an onset of glucose-lowering action within 1 hr, with blood glucose level measured significantly lower compared to the 2nd and 3rd h (p < 0.05). Insulin-loaded BaCO3 particles showed a significant decrease in blood glucose level at 1–2 h, although the glucose level started to show a slight rise at 3rd h and by 4th h, it was back to baseline level. However, although BaSO3 particles with loaded insulin showed a trend of reduction in blood glucose level, the reduction was not found to be significant (p < 0.05) at any point in time. Therefore, oral formulations of insulin/BaSO4 and insulin/BaCO3 particles were observed as effective as native insulin aspart subcutaneous formulation in terms of onset and duration of action. Further investigation will be needed to reveal bioavailability and mechanism of action of this novel Nano-Insulin formulations.

scholarly journals Increased blood glucose level following hysterectomy among reproductive women in India

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shiva S. Halli ◽  
Jang Bahadur Prasad ◽  
Rajeshwari A. Biradar
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Low Income ◽  
The Body ◽  
Reproductive Age ◽  
National Study ◽  
Surgical Removal ◽  
Cross Sectional ◽  
Targeted Interventions

Abstract Background In recent years, the hysterectomy, a surgical removal of the uterus, has received increased attention in health policy debates in India. The trigger for this was a series of media reports that highlighted an unusual surge in the number of women undergoing hysterectomies with a significant number of cases involving young and early menopausal women from low-income families. When menopause occurs as a result of hysterectomy, then the hormones such as estrogen and progesterone affect how the body cells respond to insulin. To date, we have not come across a national study following blood glucose levels among women who undergo a hysterectomy. Methods The study used the Indian fourth round of National Family Health Survey data, which is a cross-sectional nationally representative sample of 699,686 women in the age group 15–49 years and conducted during 2015–16. Bivariate and multivariate logistic regressions were used to examine the effect of hysterectomy on blood glucose level of > 140 mg/dl among women of reproductive age groups. Results The blood glucose level of > 140 mg/dl was much higher among women who had undergone a hysterectomy (12.2%) compared to non-hysterectomy women (5.7%). The pattern holds true among relevant background characteristics such as age, place of residence, education, caste, religion, wealth, marital status, body mass index (BMI), anaemia and consumption of tobacco. The adjusted odds after controlling for significant background factors, women who underwent hysterectomy experienced 15% higher odds of blood glucose level of > 140 mg/dl compared those who did not. Conclusions The results indicated increased blood glucose level among women post hysterectomy. Hence, the government of India should consider developing evidence-based policies and programming to provide effective targeted interventions for the better reproductive health of women.

A marine algal polyphenol, dieckol, attenuates blood glucose levels by Akt pathway in alloxan induced hyperglycemia zebrafish model

RSC Advances ◽  
2016 ◽  
Vol 6 (82) ◽  
pp. 78570-78575 ◽  
Author(s):  
Eun-A Kim ◽  
Seung-Hong Lee ◽  
Ji-Hyeok Lee ◽  
Nalae Kang ◽  
Jae-Young Oh ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ecklonia Cava ◽  
Akt Pathway ◽  
Zebrafish Model ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Wide Range ◽  
Marine Algal

The effect of the administering of DK (dieckol) isolated from Ecklonia cava on the blood glucose level in hyperglycemia zebrafish. Thus, hyperglycemia zebrafish could be efficiently used to evaluate a wide range of anti-diabetic activities.

scholarly journals Mathematical Modeling of the Blood Glucose Regulation System in Diabetes Mellitus Patients

2015 ◽  
Vol 70 (5) ◽  
pp. 549-560 ◽  
Author(s):  
V. A. Karpel’ev ◽  
Yu. I. Filippov ◽  
Yu. V. Tarasov ◽  
M. D. Boyarsky ◽  
A. Yu. Mayorov ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Carbohydrate Metabolism ◽  
Glucose Level ◽  
Insulin Pump ◽  
Regulation System ◽  
Level Control ◽  
Metabolism Regulation ◽  
Wide Range

Interest in the mathematical modeling of the carbohydrate metabolism regulation system increases in recent years. This is associated with a «closed loop» insulin pump development (it controls an insulin infusion depending on the blood glucose level). To create an algorithm for the automatic control of insulin (and other hormones) infusion using an insulin pump it is necessary to accurately predict glycaemia level. So, the primary objective of mathematical modeling is to predict the blood glucose level changes, caused by the wide range of external factors. This review discusses the main mathematical models of blood glucose level control physiological system (simplified insulin–glucose system). The two major classes of models — empirical and theoretical — are described in detail. The ideal mathematical model of carbohydrate metabolism regulatory system is absent. However, the success in the field of blood glucose level control modeling and simulating is essential for the further development of diabetes prevention and treatment technologies, and creating an artificial pancreas in particular.

Glucose homeostasis with infinite gain: further lessons from the Daisyworld parable?

1997 ◽  
Vol 154 (2) ◽  
pp. 187-192 ◽  
Author(s):  
J H Koeslag ◽  
P T Saunders ◽  
J A Wessels
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Cell Activity ◽  
Β Cells ◽  
Β Cell ◽  
Set Point ◽  
Black And White ◽  
Wide Range ◽  
Glucagon And Insulin

Abstract A major unresolved physiological problem is how the rate of hepatic glucose production is increased to match the increased rate of glucose utilization during exercise without a change in arterial blood glucose level. A homeostat with such capabilities is said to have infinite gain. Daisyworld is an imaginary planet orbiting a variable star. The only life is black and white daisies. Black daisies retain heat, slightly warming the planet; white daisies cool it. When the two types of daisies grow best at slightly different temperatures, variations in solar luminosity (over a wide range) cause the ratio of white:black daisies to vary in a manner that keeps the planetary temperature constant. This model therefore achieves infinite gain by having two opposing but interdependent controllers. Here we suggest that the pancreatic islet α- and β-cells might act as black and white daisies. For the analogy to apply, glucagon and insulin must not only have opposing effects on the blood sugar concentration, but the secretion of the one has, at some quantum level, to be at the expense of the other. Electrical coupling between heterocellular groups of α- and β-cells within the pancreatic islets suggests that this might indeed be the case. α-Cell activity must, furthermore, promote secretory activity in other α-cells; similarly with β-cells. This is probably mediated via pancreastatin and γ-amino butyric acid (GABA) which are paracrinically co-secreted with glucagon and insulin, respectively. α-Cell activity spreads (at the expense of β-cell activity) when the blood glucose level is below set point, while β-cell activity progressively replaces α-cell activity above set point. At set point changes in the ratio of α:β-cell activity are inhibited. Journal of Endocrinology (1997) 154, 187–192

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