Case series of: Quadrigeminal plate cistern lipoma on MRI imaging

Background: Radiolabeled prostate-specific membrane antigen PSMA-based PET/CT or PET/MRI is a whole-body imaging technique currently performed for the detection of prostate cancer lesions. PSMA has been also demonstrated to be expressed by the neovasculature of many other solid tumors. Objective: The aim of this review is to evaluate the possible diagnostic role of radiolabeled PSMA PET/CT or PET/MRI in patients with gliomas and glioblastomas, by summarizing the available literature data. Methods: A comprehensive literature search of the PubMed/MEDLINE, Scopus, Embase and Cochrane library databases was conducted to find relevant published articles about the diagnostic performance of radiolabeled PSMA binding agents in PET/CT or PET/MRI imaging of patients with suspected gliomas or glioblastomas. Results: Seven case reports or case series and 3 studies enrolling more than 10 patients showed that gliomas and glioblastoma are PSMA-avid tumors. Conclusion: Radiolabeled PSMA imaging seems to be useful in analyzing glioma/glioblastoma. Further studies enrolling a wider population are needed to clarify the real clinical and diagnostic role of radiolabeled PSMA in this setting and its possible position in the diagnostic flow-chart.

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Intra-articular venous malformations of the knee: a diagnostic challenge

Pediatric Rheumatology ◽

10.1186/s12969-021-00640-z ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Federico Diomeda ◽

Maria Santaniello ◽

Giulia Bracciolini ◽

Angelo Ravelli ◽

Adele Civino

Keyword(s):

Early Recognition ◽

Young Patients ◽

Clinical Manifestations ◽

Case Series ◽

Venous Malformations ◽

Mri Imaging ◽

Diagnostic Challenge ◽

Complete Excision ◽

Hyperintense Signal ◽

Hypointense Signal

Abstract Background Intra-articular venous malformations (IAVM) are rare benign vascular anomalies that usually affect young patients and most common locate in the knee. The terminology of these lesions is still ill-defined, as they are often termed in the literature as synovial hemangiomas. Early diagnosis can be difficult, because they usually present with nonspecific clinical manifestations that are similar those of other rheumatic diseases, especially juvenile idiopathic arthritis (JIA). Case series We conducted a retrospective analysis of five pediatric patients admitted to our units for recurrent swelling of the knee, and compared their characteristics with those of literature reports. The average age at first symptom and time from onset to diagnosis was 3.9 years (range 18 months-7 years) and 3.5 years (range 1-7 years), respectively. In our patients, an initial misdiagnosis of JIA, bleeding disorder or traumatic arthropathy was made. On MRI imaging, the features of the lesion were similar in all patients, and were marked by isointense-to-hypointense signal in T1-weighted images, and hyperintense signal in T2-weighted images. When performed, arthrocentesis led to aspiration of bloody fluid. The diagnosis was confirmed with a biopsy and histopathologic assessment in all patients. Open surgery enabled complete excision of the mass and was followed by stable remission over time in all cases. Conclusions Our report highlights the challenges that may be posed by the detection of knee IAVM and the frequent long delay between onset of symptoms and diagnosis. The key elements for early recognition include careful assessment of patient history, demonstration of bloody fluid on arthrocentesis, and proper interpretation of MRI scanning.

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CTNI-32. CASE SERIES OF BRAF INHIBITORS FOR THE TREATMENT OF BRAFV600E GLIOBLASTOMA

Neuro-Oncology ◽

10.1093/neuonc/noab196.257 ◽

2021 ◽

Vol 23 (Supplement_6) ◽

pp. vi66-vi66

Author(s):

Naveed Wagle ◽

Jose Carrillo ◽

Akanksha Sharma ◽

Minhdan Nguyen ◽

Judy Truong ◽

...

Keyword(s):

Standard Therapy ◽

Target Therapy ◽

Controlled Trial ◽

Treatment Options ◽

Objective Response ◽

Case Series ◽

Braf V600e ◽

Molecular Profile ◽

Braf Inhibitors ◽

Mri Imaging

Abstract Glioblastoma is the most common and aggressive primary brain tumor. Beyond upfront therapy with radiation and temozolomide chemotherapy there is no standard therapy that has been effective. Inhibitors of BRAF and MEK, a downstream protein immediately following BRAF, have been shown to have survival benefit for patients with other BRAF V600E mutant neoplasm including advanced melanoma. We describe our experience using this combined target therapy for two patients with BRAF V600E mutant glioblastoma. Two adult patients with pathologically diagnosed glioblastoma presented with radiographic evidence of tumor progression after prior treatment with chemotherapy or immunotherapy. Neither had received radiation therapy within 3 months of starting treatment. Molecular characterization was performed though Caris which showed evidence of BRAF V600E mutation. BRAF inhibitors were initiated in combination with standard therapy options. MRI imaging was obtained to monitor for disease progression. BRAF inhibitors were tolerated well without any side effects not previously reported. Partial objective response was seen in both patients on subsequent MRI imaging within 8 weeks of starting treatment. Progression free survival and overall survival have not been reached in either case. BRAF inhibition may have therapeutic benefit in BRAF mutated glioblastoma. Partial response was seen in this case series. The molecular profile of glioblastoma may suggest treatment options beyond standard chemotherapy options. This series supports the use of BRAF inhibitors for the treatment of BRAFV600E glioblastoma A controlled trial should be supported.

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EXPRESS: The use of hypnotherapy as treatment for functional stroke: A case series from a single centre in the UK

International Journal of Stroke ◽

10.1177/1747493021995590 ◽

2021 ◽

pp. 174749302199559

Author(s):

Ranjan Sanjal ◽

Marko Raseta ◽

Indira Natarajan ◽

Christine Roffe

Keyword(s):

Acute Stroke ◽

Therapeutic Option ◽

Current Model ◽

Case Series ◽

Symptomatic Improvement ◽

Treatment Session ◽

Controlled Study ◽

Mri Imaging ◽

Recurrence Rates ◽

Stroke Treatment

Background: Functional Neurological Disorder (FND) is defined by symptoms not explained by the current model of disease and its pathophysiology. It is found in 8.4% of patients presenting as acute stroke. Treatment is difficult and recurrence rates are high. We introduced hypnotherapy as a therapeutic option in addition to standard stroke unit care. Methods: This is an observational study of successive patients with FND presenting as acute stroke treated with hypnotherapy between 1.04.2014 and 1.02.2018. The diagnosis of FND was confirmed by clinical exam and CT/MRI imaging. Hypnosis was delivered by a hypnotherapy trained stroke physician using imagery for induction. A positive response was defined as a National Institutes of Health Stroke (NIHSS) score reduction to 0 or by â¥ 4 points post hypnotherapy. Costs were calculated as therapist time and benefits as reduction in disability/bed days. Results: 68 patients (mean age 36.4 years, 52 (76%) females, mean baseline NIHSS 5.0 (range 1-9)) were included. Two patients (3%) could not be hypnotized. Fifty-eight 58 (85%) responded, 47 (81%) required one treatment session, while 19% needed up to three sessions for symptomatic improvement. No adverse events were observed. Disability (modified Rankin Scale) reduced from a mean of 2.3 to 0.5 resulting in an average cost saving of Â£1,658 per patient. Most (n=50, 86%) remained well without recurrence at 6 month follow-up. Conclusions: In this case series hypnotherapy was associated with rapid and sustained recovery of symptoms. A prospective randomized controlled study is required to confirm the findings and establish generalizability of the results.

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Similar results for revision ACL with and without a lateral extra-articular reconstruction. A prospective evaluation

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967118s00190 ◽

2018 ◽

Vol 6 (12_suppl5) ◽

pp. 2325967118S0019

Author(s):

Juan Pablo Zicaro ◽

Carlos Yacuzzi ◽

Ignacio Garcia-Mansilla ◽

Matias Costa-Paz

Keyword(s):

Case Series ◽

Lysholm Score ◽

Consecutive Series ◽

Return To Sports ◽

Mri Imaging ◽

Significant Difference ◽

Group 2 ◽

One Year ◽

Group 1

Objectives Lateral extra-articular augmentation procedure (LEAP) has been proposed as an additional technique in the setting of revision ACL Reconstruction (ACLR). Few case series have been reported. The purpose of this study was to compare the clinical results and return to sports of a consecutive series of patients treated for revision ACLR with and without a LEAP. Methods We prospectively evaluated a series of patients treated for isolated revision ACL between 2014 and 2015 (group 1) and revision ACL associated with a LEAP from 2015 to 2016 (group 2). We analyzed the surgical technique and graft used for primary and revision ACL and for the LEAP. All patients were evaluated at one-year follow-up with Lysholm score and IKDC evaluation, return to sports and MRI evaluation. Results Thirty-six patients were evaluated, eighteen patients in each group. For the revision ACL procedures, 14 autografts and 4 allografts were used in group 1 and 16 autografts and 2 allografts in group 2. For the LEAP, in 13 cases we performed a lateral tenodesis using ilio-tibial band and in 5 patients we used allograft. The mean age was 32 years (SD 8,5) for group 1 and 28,4 (SD 6,5) for group 2. In group 1, the median Lysholm and IKDC scale was 90 (IQR 27) and 80 (IQR 40) respectively, and in group 2 the median was 90 (IQR 48) and 67,5 (IQR 33) respectively. The difference for IKDC was statistically significant (p=0,000). Eight patients return to sports in group 1 and seven in group 2. The MRI shown and homogeneous neoligament in 66% of patients in group 1 and 61% in group 2. Conclusion Despite there was a statistically significant difference in IKDC results in favor of group 2, we found no differences in return to sports, Lysholm score and MRI imaging when a LEAP was associated at one year follow-up.

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MRI imaging of vein of Galen malformations at Steve Biko Academic Hospital: A mini case series

South African Journal of Radiology ◽

10.4102/sajr.v15i2.328 ◽

2011 ◽

Vol 15 (2) ◽

pp. 53-55

Author(s):

Liesel D ◽

J Smal ◽

Z Lockhat

Keyword(s):

Case Series ◽

Vein Of Galen ◽

Mri Imaging ◽

Academic Hospital

N/A

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Spectrum of Neuroimaging Findings in Post-COVID-19 Vaccination: A Case Series and Review of Literature

Neurology International ◽

10.3390/neurolint13040061 ◽

2021 ◽

Vol 13 (4) ◽

pp. 622-639

Author(s):

Shitiz Sriwastava ◽

Ashish K. Shrestha ◽

Syed Hassan Khalid ◽

Mark A. Colantonio ◽

Divine Nwafor ◽

...

Keyword(s):

Literature Review ◽

Sinus Thrombosis ◽

Case Series ◽

Transverse Myelitis ◽

Neurological Complications ◽

Guillain Barre Syndrome ◽

Mri Imaging ◽

Guillain Barré Syndrome ◽

Case Presentations ◽

Guillain Barré

Background and Purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in Wuhan, China in December 2019. Symptoms range from mild flu-like symptoms to more severe presentations, including pneumonia, acute respiratory distress syndrome (ARDS), and even death. In response to the COVID-19 pandemic, the Emergency Use Authorization (EUA) approved the use of several vaccines. Because vaccines have been fast-tracked for emergency use, the short and long-term safety profile has been an area of concern. The aim of this paper is to extensively review published literature regarding post-COVID-19 vaccination neurological complications and characterize neuroimaging findings from three case presentations for early diagnosis and treatment. Methods: The analysis includes data from PubMed and Google Scholar. Articles included were retrieved from database inception beginning December 2020 with no language restrictions. Terms used include “SARS-CoV-2”, “post Covid vaccination”, “neurological complications”, “Guillain-barre Syndrome”, “Transverse-myelitis”, “Cerebral Venous Sinus thrombosis”, and “Cerebral hemorrhage”. Results: The literature review yielded several neurological complications post vaccination, including cerebral sinus venous thrombosis, transverse myelitis, Guillain-Barré Syndrome and optic neuritis, to name a few. Patient case presentation findings were consistent with documented results in published literature. Conclusions: We present a case series with a thorough literature review documenting adverse neurological affects following COVID-19 vaccination. Our case presentations and literature review highlight the importance of neuroimaging when diagnosing post-COVID-19 vaccination adverse effects. MRI imaging study is an important tool to be considered in patients presenting with post-COVID-19 vaccination-related unexplained neurological symptoms for accurate diagnosis.

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