scholarly journals Therapeutic Effects of Aqueous Extract of Pheonix Dactilyfera on Lead Acetate Induced Sperm Toxicity in Adult Male Wistar Rats

2014 ◽  
Vol 9 (4) ◽  
pp. 14-20
Author(s):  
Raji K. B ◽  
◽  
Tanko M ◽  
J. Danladi ◽  
Abel A. N ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Adult Male ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Therapeutic Effects ◽  
Male Wistar Rats

scholarly journals Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats

2020 ◽  
Vol 43 (2) ◽  
pp. 174-182 ◽  
Author(s):  
Sunday Aderemi Adelakun ◽  
Victor Okoliko Ukwenya ◽  
Grace Temitope Akingbade ◽  
Olusegun Dare Omotoso ◽  
Julius Akomaye Aniah
Keyword(s):  
Aqueous Extract ◽  
Adult Male ◽  
Wistar Rats ◽  
Solanum Melongena ◽  
Mercury Chloride ◽  
Testicular Toxicity ◽  
Male Wistar Rats

scholarly journals Effects of Aqueous Extract of Ocimum gratissimum Leaves and Vitamin C on Lead Acetate-induced Changes in the Thymus of Adult Wistar Rats

2019 ◽  
pp. 1-9
Author(s):  
G. N. Okechukwu ◽  
E. Ezor ◽  
E. Finbarrs-Bello ◽  
L. N. Ebube ◽  
G. C. Uzomba ◽  
...  
Keyword(s):  
Vitamin C ◽  
Aqueous Extract ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Lead Toxicity ◽  
Wistar Rat ◽  
Ocimum Gratissimum ◽  
Ameliorative Effect ◽  
Male Wistar Rats ◽  
Induced Changes

Lead is a heavy metal found in earth’s crust. It is a widespread and insidious environmental toxin known as a severe and aggressive contaminant to human and animal organisms’ health status. This work is aimed at evaluating the effect of aqueous extract of Ocimum gratissimum (OG) on lead induced changes in the thymus of adult albino wistar rats. Thirty five male Wistar rats were used in the study and were randomly divided into seven groups with five rats in each group. The rats in Group one (G1) served as the Control and received distilled water. Group 2 received 120 mg/kg body weight (bwt) of lead acetate, G3 received 375 mg/kg bwt of OG only. G4 received 120 mg/kg bwt of lead acetate and OG extract at 375 mg/kg bwt., G5 received 120 mg/kg bwt of lead and OG at 750 mg/kg bwt. G6 received 375 mg/kg bwt of OG in two weeks followed by 120 mg/kg bwt of lead acetate for one week, while G7 received 120 mg/kg bwt of lead acetate and Vitamin C at 11900 mg/kg. All the administrations were carried out orally for twenty one (21) days. At the end of the administration, the rats were fasted for 24 hours. They weighted and humanely sacrificed via cervical dislocation. The thymus were harvested in all the groups and prepared for histological studies using routine haematoxylin and eosin (H&E) staining techniques. The result of the present study shows that lead possessed a distortive effect in the histoarchitecture of thymus of the wistar rat in G2 when compared with G1. Treatment of these experimental animals with vitamin C prove to posses more ameliorative effect in restoring the histoarchitecture on lead toxicity in the thymus closed to normal than OG. Therefore, it is suggested that aqueous extract OG can act via the same pathway as vitamin C, in maintaining the normal histological structures of the thymus of adult albino wistar rat exposed to lead toxicity.

scholarly journals Biochemical Assessment of Fertility-Enhancing Effect of Aqueous Extract of Symphonia globulifera (Linn. F.) In Adult Male Wistar Rats

2021 ◽  
Vol 3 (2) ◽  
pp. 01-06
Author(s):  
Ilesanmi O. S
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Adult Male ◽  
Wistar Rats ◽  
Follicle Stimulating Hormone ◽  
Phytochemical Screening ◽  
Male Wistar Rats ◽  
Symphonia Globulifera ◽  
Hormonal Analysis ◽  
Stimulating Hormone

The present study investigated the effect of oral administration of aqueous extract of Symphonia globulifera root on fertility in addition to its effect on some biochemical indices in adult male Wistar rats. After the aqueous extraction, phytochemical screening was carried out. Twenty-four (24) mature and healthy adult male wistar rats of weights between 150-220 g were used. The rats were randomly divided into four (4) groups each containing six (6) rats. Group 1 rats were gavaged with distilled water which served as control group. Group 2, 3 and 4 rats were orally treated with 100, 200 and 400 mg/kg body weight of the aqueous extract of S. globulifera respectively for 21 days. After the treatment, the rats were sacrificed and their organs (heart, liver, kidney and testes) were excised. Hormonal analysis which include seminal fluid analysis (SFA), follicle stimulating hormone (FSH), leutenizing hormone (LH), testosterone and prolactin were carried out following standard procedures. The data were analysed using students t-test and ANOVA with the aid of SPSS with P < 0.05 level of statistical significance. The phytochemical screening of the extract revealed presence of major phytochemicals. There was dose-dependent decrease in the body weight of the rats after the treatment. In hormonal analysis, SFA increased significantly when compared to that of the control rats. The analysis also revealed that the blood level of follicle stimulating hormone (FSH) was significantly increased whereas; there was decrease in testosterone level when compared with the control animals. In conclusion, aqueous extract of S. globulifera was found to be safe and showed significant fertility enhancing effects.

Comparing the Neuroprotective Effects of Aqueous and Methanolic Extracts of Vernonia Amygdalina on the Cerebellum of Adult Male Wistar Rats

2020 ◽  
Vol 9 (1) ◽  
pp. 145-159
Author(s):  
Ugochukwu Samuel Aguwa ◽  
Somadina M Okeke ◽  
Chijioke M Okeke ◽  
Chinyere S Eze ◽  
Benedict Nzube Obinwa ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Adult Male ◽  
Wistar Rats ◽  
Methanolic Extract ◽  
Mercury Chloride ◽  
Phytochemical Analysis ◽  
Vernonia Amygdalina ◽  
Orthodox Medicine ◽  
Methanolic Extracts ◽  
Male Wistar Rats

The solvent of extraction determines the type and amount of phytochemicals extractible from a plant material. Reports have shown that numerous African herbs are rich is potent phytochemicals which have been used in folkloric and orthodox medicine in the prevention and treatment of ailments. This research is geared towards comparing the neuroprotective potency of the aqueous and methanolic extracts of Vernonia amygdalina on the cerebellum of mercury chloride intoxicated Wistar rats. Thirty adult male Wistar rats were divided into 6 groups of 5 rats each. Group A was the negative control and had food and water only. Group B was the positive control and was exposed to mercury chloride without treatment. Groups C1 and C2 received 200mg/kg bw of aqueous and methanolic extracts respectively while groups D1 and D2 received 400mg/kg bw of aqueous and methanolic extracts of Vernonia amygdalina respectively. Result of phytochemical analysis shows that water extracted more flavonoids while methanol extracted more phenols. The results of antioxidant studies show that the methanolic extract conferred more protection against oxidative stress than the aqueous extract. Histological results show that aqueous extract conferred more protection than the methanolic extract. We therefore conclude from our report that both the aqueous and methanolic extracts of Vernonia amygdalina confer neuroprotection on the cerebellum of Wistar rats.

scholarly journals Histological and Biochemical Evaluation of the Kidney following Chronic Consumption of Hibiscus sabdariffa

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
U. U. Ukoha ◽  
S. I. Mbagwu ◽  
G. U. Ndukwe ◽  
C. Obiagboso
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Chronic Administration ◽  
Therapeutic Effects ◽  
Hibiscus Sabdariffa ◽  
Biochemical Assays ◽  
Male Wistar Rats ◽  
Biochemical Evaluation ◽  
Biochemical Indices ◽  
Histological Results

Hibiscus sabdariffa L. has been used traditionally as herbal medicine and has been documented to have a broad range of therapeutic effects. The present study aimed to investigate the effects of chronic administration of aqueous extract of flowers of Hibiscus sabdariffa on the histology of the kidney and some biochemical indices of renal function in male Wistar rats. Twenty (20) Wistar rats were randomly divided into four (4) groups of five rats each. The extract was administered orally in doses 200, 500, and 800 mg/kg body weight for 21 days. The kidney was harvested and processed histologically and blood samples were taken for biochemical assays. The histological results showed dose dependent pathological states and the biochemical analysis revealed a dose dependant variation in renal indices. These results suggest that chronic administration of aqueous extract of Hibiscus sabdariffa may be toxic to the kidney.

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