scholarly journals Application of the immune-correcting therapy in complex treatment of surgical forms of erysipelas

2021 ◽  
Vol 88 (5-6) ◽  
pp. 53-55
Author(s):  
S. D. Shapoval ◽  
L. L. Vorontsova ◽  
L. A. Vasylevska
Keyword(s):  
Immune System ◽  
Complex Treatment ◽  
Immune Disorders ◽  
Municipal Hospital

Objective. To investigate the efficacy of immunomodulating and immunostimulating therapy in complex treatment of patients, suffering surgical forms of erysipelas.Materials and methods. Retrospectively and prospectively there were analyzed 284 patients’ hospital charts, who were treated stationary in Centre of Purulent-Septic Surgery of Zaporizhzhya Municipal Hospital №3 in 2016 - 2021 yrs. Results. In patients, suffering erythematous form of erysipelas, disorders in cellular and humoral chains of immunity were not revealed. The immune disorders formula in bullous form was following: CD3 + 1, CD4 + 1, CD8-1, CD16-2, CD22-1, what witnessed about misbalance of the immune system Degree I, of possibly compensatory character; in a phlegmonous one - CD3 + 1, CD4-1, CD8-1, CD16-2, CD22-1, witnessing actuality of the immune disorders of Degree І, while in the necrotic one - CD3-2, CD4-2, CD8-1, CD16-2, CD22-1, trusting presence of the immune disorders of Degree ІІI. Conclusion. Administration of erbisol-extra and laferon for destructive forms of erysipelas is pathogenetically substantiated and may be applied in complex treatment of the disease.

The Ouroboros of Inflammatory Signaling to the Brain for the Control of Neuroendocrine Function

2021 ◽  
Author(s):  
Georgia E. Hodes
Keyword(s):  
Nervous System ◽  
Immune System ◽  
Immune Regulation ◽  
The Body ◽  
Immune Disorders ◽  
Inflammatory Signaling ◽  
Late 20Th Century ◽  
Immune Systems ◽  
Neuroendocrine Function ◽  
The Brain

In the late 20th century, the discovery that the immune system and central nervous system were not autonomous revolutionized exploration of the mechanisms by which stress contributes to immune disorders and immune regulation contributes to mental illness. There is increasing evidence of stress as integrated across the brain and body. The immune system acts in concert with the peripheral nervous system to shape the brain’s perception of the environment. The brain in turn communicates with the endocrine and immune systems to guide their responses to that environment. Examining the groundwork of mechanisms governing communication between the body and brain will hopefully provide a better understanding of the ontogeny and symptomology of some mood disorders.

scholarly journals Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

2019 ◽  
Vol 6 (10) ◽  
pp. 1956-1973 ◽  
Author(s):  
Liane I. F. Moura ◽  
Alessio Malfanti ◽  
Carina Peres ◽  
Ana I. Matos ◽  
Elise Guegain ◽  
...  
Keyword(s):  
Immune System ◽  
Infectious Diseases ◽  
Physicochemical Properties ◽  
Delivery Systems ◽  
Branched Polymers ◽  
Immune Disorders ◽  
System P ◽  
Immunomodulatory Properties

The review focus on branched polymers as promising delivery systems with immunomodulatory properties against cancer and infectious diseases. It covers their physicochemical properties and on how those can be tailored to modulate the immune system.

Possibilities of recombinant cytokines in the structure of training of highly qualified athletes

2021 ◽  
pp. 16-30
Author(s):  
S.P. Alpatov
Keyword(s):  
Immune System ◽  
Environmental Factors ◽  
Interleukin 2 ◽  
Climatic Conditions ◽  
The Body ◽  
Immune Disorders ◽  
Highly Qualified ◽  
Depressing Effect ◽  
Cytokine Network ◽  
Mechanisms Of Adaptation

Serious sports achievements are associated with extreme impacts on the human body: psycho-emotional and physical loads of the training period, competitions requiring the mobilization of all the adaptive reserves of the body, changes in climatic conditions when athletes move long distances, adverse environmental factors leading to hypothermia. The combination of these factors has a depressing effect on the immune system. The emergence of immune disorders in athletes during periods of extreme physical and psycho-emotional stress made it possible to identify the mechanisms of adaptation failure and depletion of immunity reserves, which requires corrective measures. Roncoleukin® is a complete structural and functional analogue of endogenous interleukin-2 (IL-2) and has the same spectrum of functional activity. It is able to compensate for the deficiency of IL-2 and reproduce its effects as one of the key components of the cytokine network.

scholarly journals Mechanistic Implications of Biomass-Derived Particulate Matter for Immunity and Immune Disorders

Toxics ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 18
Author(s):  
Arulkumar Nagappan ◽  
Su Bum Park ◽  
Su-Jun Lee ◽  
Yuseok Moon
Keyword(s):  
Particulate Matter ◽  
Immune System ◽  
Immune Responses ◽  
Molecular Mechanisms ◽  
Urban Air Pollution ◽  
Allergic Diseases ◽  
Immune Disorders ◽  
Immunological Effects ◽  
Molecular Machinery ◽  
Increased Susceptibility

Particulate matter (PM) is a major and the most harmful component of urban air pollution, which may adversely affect human health. PM exposure has been associated with several human diseases, notably respiratory and cardiovascular diseases. In particular, recent evidence suggests that exposure to biomass-derived PM associates with airway inflammation and can aggravate asthma and other allergic diseases. Defective or excess responsiveness in the immune system regulates distinct pathologies, such as infections, hypersensitivity, and malignancies. Therefore, PM-induced modulation of the immune system is crucial for understanding how it causes these diseases and highlighting key molecular mechanisms that can mitigate the underlying pathologies. Emerging evidence has revealed that immune responses to biomass-derived PM exposure are closely associated with the risk of diverse hypersensitivity disorders, including asthma, allergic rhinitis, atopic dermatitis, and allergen sensitization. Moreover, immunological alteration by PM accounts for increased susceptibility to infectious diseases, such as tuberculosis and coronavirus disease-2019 (COVID-19). Evidence-based understanding of the immunological effects of PM and the molecular machinery would provide novel insights into clinical interventions or prevention against acute and chronic environmental disorders induced by biomass-derived PM.

scholarly journals Immune modulatory effects of probiotic Streptococcus thermophilus on human monocytes

2020 ◽  
Author(s):  
Narges Dargahi ◽  
Joshua Johnson ◽  
Vasso Apostolopoulos
Keyword(s):  
Immune System ◽  
Gastrointestinal Tract ◽  
Dairy Products ◽  
Streptococcus Thermophilus ◽  
Human Monocytes ◽  
Immune Disorders ◽  
Beneficial Effects ◽  
Routine Administration ◽  
Fermented Dairy Products ◽  
Fermented Dairy

ABSTRACTIngesting probiotics contributes to the development of a healthy microflora in the gastrointestinal tract with established benefits to human health. Some of these beneficial effects may be through modulating of the immune system and probiotics have become more common in the treatment of many inflammatory and immune disorders. We demonstrate a range of immune modulating effects of Streptococcus thermophilus by human monocytes, including, decreased mRNA expression of IL-1R, IL-18, IFNγR1, IFNαR1, CCL2, CCR5, TLR-1, TLR-2, TLR-4, TLR-5, TLR-6, TLR-8, CD14, CD86, CD4, ITGAM, LYZ, TYK2, IFNR1, IRAK-1, NOD2, MYD88, ITGAM, SLC11A1, and, increased expression of IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-23, IFNγ, TNFα, CSF-2. Routine administration of Streptococcus thermophilus in fermented dairy products, and their consumption may be beneficial to the treatment/management of inflammatory and autoimmune diseases.

scholarly journals Loss of microbiota depletes cross-reactive Foxp3+ Tregs leading to selective immunopathologies

2017 ◽  
Author(s):  
Tirumalai Kamala ◽  
David Usharauli
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Predictive Power ◽  
Hygiene Hypothesis ◽  
Immune Disorders ◽  
Evolutionary Time ◽  
Specific Nature ◽  
Vaccine Responses ◽  
Commensal Microbiota

The 'Hygiene hypothesis', a cornerstone model to account for the role of exogenous pathogens and later of endogenous microbiota in immune disorders, is currently presumed to operate at the innate immunity and metabolite levels to properly 'educate' the immune system. Doing so however fails to satisfactorily account for the antigen-specific nature of such disorders. SPIRAL is a novel interpretive framework that resolves this dilemma. It represents the periodic table of cross-reactive Foxp3+ regulatory T cell (Treg) epitopes selected from commensal microbiota over evolutionary time to mediate self-nonself discrimination and effector class regulation. Here, we utilize the SPIRAL's predictive power to provide a mechanistic antigen-specific basis for the initiation of allergies and autoimmune diseases as well as for the failure to mount effective anti-tumor and vaccine responses through selective loss of microbiota and corresponding cross-reactive Foxp3+ Tregs.

Specific immunotherapy in patients with infectious -and-allergic rhinitis

1995 ◽  
Vol 76 (1) ◽  
pp. 36-37
Author(s):  
F. A. Fattakhova
Keyword(s):  
Allergic Rhinitis ◽  
Immune System ◽  
Cellular Immunity ◽  
Specific Immunotherapy ◽  
Clinical Results ◽  
Immune Disorders ◽  
Humoral And Cellular Immunity

The improvement and normalization of the characteristics of humoral and cellular immunity and nonspecific organism protection correspond to the good and excellent results of immunotherapy, whereas in unsatisfactory and satisfactory results the pathologic ships in immune system are conserved,, ov the insignificant positive dynamics of immunologic characteristics is observed. The presence ot immune disorders after the immunotherapy course by bacterial allergens is an indication for the following extension without regard to the clinical results obtained up to, the normalisation and improvehent of immunologic characteristics.

The systemic immunity humoral link status in patients with traumatic illness

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
I. M. Plehutsa ◽  
R. I. Sydorchuk
Keyword(s):  
Immune System ◽  
B Lymphocytes ◽  
Cellular Immunity ◽  
Surgical Intervention ◽  
Traumatic Injury ◽  
Control Group ◽  
Immune Disorders ◽  
Comparison Groups ◽  
Integrated Indicators

The influence of trauma on parameters of humoral immunity changes has been studied. The study includes 52 patients with various forms of traumatic illness, aged 18-69 years (37,91±4,28). The control group consisted of 16 patients who had undergone a routine surgery not related to the pathology of musculoskeletal system. All patients of the main group were divided into 3 groups according to the severity of their condition. Analysis of parameters of cellular link of immune system was performed by defining the pool of B-lymphocytes (CD22+ lymphocytes), determination of main classes' immunoglobulins, and calculation of integrated indicators. The highest expression (immune disorders of II-III grades) of changes of cellular immunity was observed in patients with severe traumatic illness (detailed clinical picture). Surgical intervention, even without traumatic injury significantly affect cellular immunity, but in patients with traumatic illness immunity disorders were significantly higher than in the comparison groups. 

scholarly journals miRNA-124 in Immune System and Immune Disorders

2016 ◽  
Vol 7 ◽  
Author(s):  
Zhen Qin ◽  
Peng-Yuan Wang ◽  
Ding-Feng Su ◽  
Xia Liu
Keyword(s):  
Immune System ◽  
Immune Disorders

scholarly journals The relationship between the pituitary somatotrophic function and the immune system, its role in the development of neoplasia

2013 ◽  
Vol 59 (1) ◽  
pp. 30-34
Author(s):  
S A Dogadin ◽  
M A Dudina ◽  
A A Savchenko
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Immune System ◽  
Immune Cells ◽  
Functional Activity ◽  
Immune Disorders ◽  
Neoplastic Processes ◽  
The Relationship ◽  
Survivorship Rate

The present review is focused on the relationship between growth hormone (GH) production and the state of the immune system. The influence of growth factors on the population and subpopulation composition of CD-expressing lymphocytes, functional activity of immune cells, and apoptosis is discussed. The detailed description of the role of disturbances in the pituitary somatotrophic function and the concomitant immune disorders is presented with special reference to the development of neoplastic processes. Changes in the immune system of the patients with chronic hypersecretion of growth factors are described. Tight interactions between the immune and endocrine systems appear to greatly contribute to tumour pathogenesis and have direct effect on the survivorship rate among the patients with acromegaly.

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