laser ionization
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Author(s):  
Michael Stumpf ◽  
Matthias Melchger ◽  
Severin Georg Montag ◽  
Georg Pretzler

Abstract We present an optical setup for well-defined ionization inside a plasma such that precisely controlled spots of high electron density can be generated. We propose to use the setup for Trojan Horse Injection (or Plasma Photocathode Emission) where a collinear laser beam is needed to release electrons inside a plasma wakefield. The reflection-based setup allows a suitable manipulation of the laser near field without disturbing the spectral phase of the laser pulses. A required ionization state and volume can be reached by tuning the beam size, pulse duration and pulse energy. The ionization simulations enable a prediction of the ionization spot and are in good agreement with dedicated experiments which measured the number of electrons created during the laser-gas interaction.


2021 ◽  
Author(s):  
Evgenia S. Abramova ◽  
Sergey F. Balandin ◽  
Vyacheslav F. Myshkin ◽  
Maria S. Pavlova ◽  
Vitaliy L. Khazan ◽  
...  

2021 ◽  
Vol 55 (6) ◽  
pp. 550-561
Author(s):  
A. E. Chumikov ◽  
V. S. Cheptsov ◽  
N. G. Managadze ◽  
G. G. Managadze

2021 ◽  
Vol 8 ◽  
Author(s):  
Zeynep Talip ◽  
Francesca Borgna ◽  
Cristina Müller ◽  
Jiri Ulrich ◽  
Charlotte Duchemin ◽  
...  

The β−-particle-emitting erbium-169 is a potential radionuclide toward therapy of metastasized cancer diseases. It can be produced in nuclear research reactors, irradiating isotopically-enriched 168Er2O3. This path, however, is not suitable for receptor-targeted radionuclide therapy, where high specific molar activities are required. In this study, an electromagnetic isotope separation technique was applied after neutron irradiation to boost the specific activity by separating 169Er from 168Er targets. The separation efficiency increased up to 0.5% using resonant laser ionization. A subsequent chemical purification process was developed as well as activity standardization of the radionuclidically pure 169Er. The quality of the 169Er product permitted radiolabeling and pre-clinical studies. A preliminary in vitro experiment was accomplished, using a 169Er-PSMA-617, to show the potential of 169Er to reduce tumor cell viability.


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