Features of the development of the sphere of biomedical cell products in Russia

The successful development of the economy of a modern state is directly related to the entry into the market of new advanced therapy medicinal products. For Russia, the process of developing and implementing biomedical cell products will become the basis for the successful transformation of the pharmaceutical market into a knowledge-intensive market economy. Biomedical cell products can act as one of the main tools of such a promising and capital-intensive direction as regenerative medicine. The field of biomedical cell products therapy is developing rapidly, but there are still questions about the safe use of biomedical cell products therapy. The growing need for effective recommendations for the participants of the biomedical cell products market has determined the relevance of this study. Multivariate analysis of the prospects and barriers to the development of the biomedical cell products market to justify and develop recommendations for investors, pharmaceutical manufacturers and distributors for the production and sale of biomedical cell products in Russia. Materials and methods. The materials were regulatory legal documents of regulatory bodies: the USA, the EU, the Russian Federation, the EAEU, as well as analytical materials of open access. Results. A comparative analysis of the production features and the formation of the cost of autologous and allogeneic biomedical cell products revealed the ways of development of the biomedical cell products market. Further, the key directions of the prospective development of the biomedical cell products market were identified and characterized, risk factors, drivers and barriers were identified. Conclusion. In the direction of regulatory support: – create a general register for monitoring the results of research and the use of biomedical cell products. – to develop an information environment for comparing large sets of biomedical cell products life cycle data obtained from different sources; – to develop regulatory approaches to the circulation of biomedical cell products in the market. In the direction of technological support: – plan the implementation of automation of all stages of the production process; – to provide for the development of technology transfer methods; – to maintain the pharmaceutical quality system in an up-to-date functioning state; – implement a platform for training qualified personnel for this field. In the direction of marketing support: – to create logistics chain systems, with the help of integration technologies, capable of ensuring uninterrupted supply of biomedical cell products with minimal risks to the quality of the supply chain reliability; – supply planning should take into account the stability and storage conditions of the biomedical cell products; – scaling up production leads to a reduction in cost, and an increase in the use of biomedical cell products in routine medical practice leads to an increase in the present value; – conduct training of production employees, distributors and medical personnel. – develop a commercialization strategy for each biomedical cell products separately.

Leveraging technology and supply chain to improve family planning logistics in Pakistan

Background: Pakistan and USAID have invested in improving the contraceptive supply chain data and commodity security. In 2011, the first digital contraceptive logistics management information system (cLMIS) was launched, enabling supply chain data visibility from the federal level to health facilities. The system has built-in modules on forecasting and supply planning, inventory management, consumption reporting, business intelligence tools, automatic email and SMS alerts. Using these features, policy-makers and health managers annually forecast needs, and procure contraceptives accordingly. Aims: The objective of this research was to understand the existing technological platforms for family planning (FP) supply chain data visibility and the potential impact on contraceptive commodity security. Methods: The authors reviewed available published and grey literature papers on contraceptives and supplies in Pakistan. We extracted data from the cLMIS, evaluated indicators including reporting compliance, reported stock-out rates, and contraceptive performance. The analysis was validated by reviewing supply chain and FP indicators, such as average monthly consumption, months of stock, and couple years of protection. Results: The cLMIS has resulted in improved distribution, early warning and accountability at the lowest tiers in the FP supply chain in the public sector. At the facility level, FP commodity availability increased from 40% in 2009 to 84% in 2018. Conclusion: Contraceptive supply chain has seen significant growth over the past decade to meet expanding reproductive health evidence to inform strategic decisions; cLMIS is a prime contributor to improvements registered in FP stock availability at public sector facilities

Tuning value chains for better signals in the post-COVID era: vaccine supply chain concerns

PurposeThe authors identify the critical bottlenecks that exist in the vaccine supply chain that are preventing a robust coronavirus disease (COVID) response. The authors posit that improved supply chain signals can result in improved handling and distribution of vaccines in a post-COVID world and identify recommendations for redesign of the vaccine supply chain as well as future research questions for scholars.Design/methodology/approachThe supply chain operating reference (SCOR) model is used as a framework to identify each of the major gaps that exist in the supply chain for the COVID vaccine. The critical bottlenecks and delays that exist within this supply chain are identified through this framework and validated through the ongoing research and interviews in the field.FindingsWhilst the vaccine supply chain for influenza is perfectly sized for development and distribution of this cyclical virus, the emergence of a new virus created a pandemic, which has exposed a number of critical shortages. The authors find that the design of the COVID vaccine supply chain suffers from a flawed structure. To date, less than 3% of the United States and global population has been fully vaccinated. The authors advocate a “back to front design”, beginning with demand planning for actual vaccinations and working backwards toward supply planning and distribution planning. These lessons may be helpful for capacity planning and supply chain strategy for future vaccinations as variants of the COVID vaccine emerge.Originality/valueThe authors provide a unique approach for viewing the current shortages that exist in the vaccine supply chain and offer suggestions for new variants of this supply chain for the future.

The Value of Water—Estimating Water-Disruption Impacts on Businesses

As water serves as a necessary and often irreplaceable input in a range of goods and services, a disruption in water supply can cause lost production and sales for businesses. Thus, large benefits may be generated by reducing the risk of water disruptions. To enable selection of economically viable risk mitigation measures, the investment costs should be weighed against the benefits of risk mitigation. Consequently, quantitative estimates of the consequences of disruptions need to be available. However, despite the importance of water to businesses, the literature on their financial losses due to short and long-term water disruptions is still scarce. The aim of this paper is to estimate time-dependent water supply resiliency factors for economic sectors, i.e., a metric focusing on the level of output that businesses can uphold during a disruption, to contribute to better decision support for water supply planning and risk management. An online survey was used to gather data from 1405 companies in Sweden on consequences of complete and unplanned water supply outages. Results show that Food and beverage Manufacturing and Accommodation and food services are the two most severely affected sectors over all analyzed disruption durations.

Development of web enabled water resource information system using open source software for Patiala and SAS Nagar districts of Punjab, India

Over the globe efforts are being made to collect data and develop an adequate water resource information system for optimising its use. India is the largest consumer of water with an estimated usage of around 300 cubic kilometers per year. Punjab, a north-western state of India, is an example of severe crises aquifer depletion due to unconstrained consumption of groundwater leads to degrade the quantity as well as quality of it. Thus it is of great importance to compile up to date information about the water requirement for its appropriate and sustainable use. Remote sensing and Geographic Information system (GIS) are the technologies that can provide efficient & effective information system to tackle the water quality & water supply planning parameters. Thus, under the present study, a web enabled water resource information system has been developed in GIS environment for the SAS (Sahibzada Ajit Singh) Nagar and Patiala districts of Punjab by using the open source software – MS4W and pmapper. This system provides digital information of natural i.e. drainage & man made features like roads, canals, tube well with its location etc., and also provide the information related to water level, water quality of wells, and well depth for the study area. Such an information system can be very helpful for the administrators and can serve as a decision support system for the planners and policy makers so that the areas where the problem related to water quality can be identified and focused upon. The system can provide an effective and meaningful direction for the planning and development of both districts.

Forecast Methods and Periodic Review Inventory Model for Supply Planning to Reduce Food Waste

Food waste is an important economic and resource problem in all countries around the world. Particularly, the restaurant sector highly contributes to food waste and limited efforts or studies have been performed to overcome this problem. In this context, the present study addresses an alternative to improve the supply planning for perishable products in the restaurant sector through the application of specific forecasting methods and a stochastic inventory control model. For this purpose, a real enterprise within this economic sector was considered. Our findings support that monthly forecasts can be more appropriate for accurate demand estimation and supply planning of perishable products, which is important to reduce unnecessary products. Also, the periodic review inventory control model can lead to a more appropriate supply scheme to reduce the waste of surplus food. These findings and the proposed techniques can be used for other economic entities to reduce product waste due to poor supply planning.