Coherence Properties and Intensity Distribution of a Partially Coherent Lorentz–Gauss Beam Emerging from the Axicon

The propagation of a partially Lorentz–Gauss beam in a uniform-intensity diffractive axicon is studied according to the Huygens–Fresnel principle, the Hermite–Gaussian expansion of a Lorentz function, and using the stationary phase method. We have derived the intensity equation of a partially coherent Lorentz-Gauss beams propagating through uniform-intensity diffractive axicon, and we proved mathematically that it is the superposition of Bessel beams of various orders after emerging from axicon, using Hermite’s function series and the Bessel function integral formulas. The results show that the intensity distribution of the diffracted beam is the intensity pattern evolved from a Lorentz–Gauss shaped spot into a Gaussian-shaped spot at any position on the focal length of the axicon, and the intensity distribution of a partially Lorentz–Gauss beam generated by an axicon becomes uniform by increasing the beam width and more uniform and constant with the larger coherence width.

Hat-Top Beams for Generating Tunable THz Radiations Using a Medium of Conducting Nanocylinders

There are a large number of studies for terahertz (THz) radiation generation, but tunable THz sources are still a challenge since it is difficult to tune frequency, focus and intensity of the radiation simultaneously. The present work proposes the THz generation by the interaction of two hat-top laser beams with a host medium of argon gas containing graphite nanocylinders, as these beams result in highly nonlinear interaction because of a smooth dip in their peak intensity and a fast rise and fall in the overall intensity pattern. Such an interaction produces nonlinear current (6.7 × 108 A/m2) because of the electron cloud of the nanocylinders, which can be modulated by the laser and medium properties for realizing tunable THz radiation. The orientation of basal planes of nanocylinders is shown to be important for this mechanism, though it may be challenging for the experimentalists. The resonant excitation takes place when the plasmon frequency matches the beating frequency of the laser beams, and in the proposed mechanism one can have longitudinal surface plasmon resonance (~12 THz) and transverse surface plasmon resonance (~40 THz), leading to frequency-tunable THz radiation. The role of height and inter particle distance between the adjacent nanocylinders on the THz field amplitude and the efficiency of the mechanism is uncovered by controlling the aspect ratio in the nanocylinders. For example, reducing the inter particle distance from 180 nm to 60 nm leads to the enhancement of THz field from 1´108 V/m to 5.48´108 V/m. The profile of the emitted THz radiation is investigated in detail under the effect of various parameters in order to prove the practicality of the proposal. The proposed design and mechanism would be attractive for electromagnetic and communication societies which are dealing with millimeter-waves and THz components in addition to its medical application.

Multitarget Position-Sensitivity Security Transmission with OAM-DM Based on FDA

The multitarget position-sensitivity security transmission scheme with orbital angular momentum (OAM) directional modulation (DM) waveform using the uniform circular frequency diverse array (FDA) is proposed. The transmitter employs FDA to generate dual-mode range-dependent OAM beam pattern, and the direction information of OAM beam is modulated into the signal. According to the modulation method, orthogonal carrier frequency can be designed to realize multitarget position-dependent OAM pattern. In the undesired position, the intensity pattern and the phase front of the radio beam vary randomly with the digital transmission sequence. Because modulation waveform is position-dependent, the technique offers security, as the signal can be purposely distorted in other positions. The composite dual-mode OAM signal makes it more difficult for eavesdroppers to demodulate correct messages. The receiver with a single antenna employs the phase compensation and helical phase factor to restore the correct digital signal in the desired position. Numerical results show that multitarget position-sensitivity OAM-DM technology based on FDA offers the security transmission scheme.

The Influence of Burst-Firing EMF on Forskolin-Induced Pheochromocytoma (PC12) Plasma Membrane Extensions

Previous research has demonstrated that pheochromocytoma (PC12) cells treated with forskolin provides a model for the in vitro examination of neuritogenesis. Exposure to electromagnetic fields (EMFs), especially those which have been designed to mimic biological function, can influence the functions of various biological systems. We aimed to assess whether exposure of PC12 cells treated with forskolin to patterned EMF would produce more plasma membrane extensions (PME) as compared to PC12 cells treated with forskolin alone (i.e., no EMF exposure). In addition, we aimed to determine whether the differences observed between the proportion of PME of PC12 cells treated with forskolin and exposed to EMF were specific to the intensity, pattern, or timing of the applied EMF. Our results showed an overall increase in PME for PC12 cells treated with forskolin and exposed to Burst-firing EMF as compared to PC12 cells receiving forskolin alone. No other patterned EMF investigated were deemed to be effective. Furthermore, intensity and timing of the Burst-firing pattern did not significantly alter the proportion of PME of PC12 cells treated with forskolin and exposed to patterned EMF.

X-type vortex and its effect on beam shaping

In this article we propose a new type of optical vortex, the X-type vortex. This vortex inherits and develops the conventional noncanonical vortex, i.e., it no longer has a constant phase gradient around the center, while the intensity keeps invariant azimuthally. The strongly focusing properties of the Xtype vortex and its effect on the beam shaping in three-dimensional (3D) fields are analyzed. The interesting phenomena, which cannot be seen in canonical vortices, are observed, for instance the `switch effect' which shows that the intensity pattern can switch from one transverse axis to another in the focal plane by controlling the phase gradient parameter. It is shown that by adjusting the phase gradient of this vortex, the focal field can have marvelous patterns, from the doughnut shape to the shapes with different lobes, and the beam along propagation direction will form a twisting shape in 3D space with controllable rotation direction and location. The physical mechanisms underlying the rule of the beam shaping are also discussed, which generally say that the phase gradient of the X-type vortex, the orbital angular momentum, the polarization and the `nongeneric' characteristic contribute differently in shaping fields. This new type of vortex may supply a new freedom for tailoring 3D optical fields, and our work will pave a way for exploration of new vortices and their applications.

EXPRESS: Correlation and Difference Between Raman Spectral Characteristic and Feature Evaluation for Leukocytes and Tumor Cells

Tumor detection supported by Raman spectroscopy is becoming increasingly popular, yet the relevance of spectral variation and feature selection retains unclear. Here we determined the correlation and difference between spectral characteristic and feature evaluation for leukocytes and tumor cells. Some peaks were found to show noticeable spectral differences, and their intensity distributions were investigated, finding using Log-Normal distribution to describe Raman intensity pattern may be more appropriate. Further the importance of all Raman features was calculated, where some other peak features occupied the top status. By surveying the intensity variation and feature evaluation for those peaks, we concluded the peak with the highest importance does not correspond to the peak location with the most noticeable intensity difference in spectra. Moreover, the peak-intensity-ratio of I₁₅₁₇/I₇₁₉ associated with protein to nucleic acid level presented the maximum separation, thus it can be recognized as a special indicator to develop an alternative cancer detection. It is inspiring to introduce advanced statistical models into bio-spectroscopic fields but those intrinsic spectral variations rather than classification performance should be valued. Our explorations can provide possibilities to reveal the essences within tumor carcinogenesis based on Raman spectroscopy, further overwhelming the obstacles during the translation into clinical applications.

The vibrational properties of benzene on an ordered water ice surface

We present a hybrid CCSD(T)+PBE-D3 approach to calculating the vibrational signatures for gas phase benzene and benzene adsorbed on an ordered water-ice surface. We compare the results of our method against experimentally recorded spectra and calculations performed using PBE-D3-only approaches (harmonic and anharmonic). Calculations use a proton ordered XIh water-ice surface consisting of 288 water molecules, and results are compared against experimental spectra recorded for an ASW ice surface. We show the importance of including a water ice surface into spectroscopic calculations, owing to the resulting differences in vibrational modes, frequencies and intensities of transitions seen in the IR spectrum. The overall intensity pattern shifts from a dominating ν11 band in the gas-phase to several high-intensity carriers for an IR spectrum of adsorbed benzene. When used for adsorbed benzene, the hybrid approach presented here achieves an RMSD for IR active modes of 21 cm-1, compared to 72 cm-1 and 49 cm-1 for the anharmonic and harmonic PBE-D3 approaches, respectively. Our hybrid model for gaseous benzene also achieves the best results when compared to experiment, with an RMSD for IR active modes of 24 cm-1, compared to 55 cm-1 and 31 cm-1 for the anharmonic and harmonic PBE-D3 approaches, respectively. To facilitate assignment, we generate and provide a correspondence graph between the normal modes of the gaseous and adsorbed benzene molecules. Finally, we calculate the frequency shifts, Δν, of adsorbed benzene relative to its gas phase to highlight the effects of surface interactions on vibrational bands and evaluate the suitability of our chosen dispersion-corrected density functional theory.

Sharp focusing of beams with V-point polarization singularities

It is theoretically and numerically shown that when tightly focusing an n-th order vector light field that has the central V-point (at which the linear polarization direction is undetermined), the polarization singularity index n, and a "flower"-shaped intensity pattern with 2(n-1) lobes it forms a transverse intensity distribution with 2(n-1) local maxima. At the same time, a vector light field with the polarization singularity index -n, which has the form of a "web" with 2(n+1) cells generates at the sharp focus a transverse intensity distribution with 2(n+1) local maxima. In the focal spot, either 2(n-1) or 2(n+1) V-point polarization singularities with alternating indices +1 or -1 are formed at the intensity zero.

Propagation of Vortex Hermite-Cosh-Gaussian Beams in a Gradient-Index Medium

Based on the Huygens–Fresnel integral, the propagation equation for a vortex Hermite-cosh-Gaussian beams (vHChGB) in gradient-index medium (GIM) is derived. From the obtained expression, the evolution of the intensity and the phase distributions of a vHChGB through a GIM are numerically demonstrated as a function of the gradient-index parameter β under the change of incident beam parameters. The results show that the characteristics of the output beam evolve periodically versus the propagation distance, and the period of evolution slows down when β is increased. Furthermore, it is demonstrated that the self-repeating properties of the intensity pattern and the phase distribution for the propagated vHChGB are altered by the incident beam parameters. The results obtained may be beneficial for applications in fiber communications and beam shaping.

ionbot: a novel, innovative and sensitive machine learning approach to LC-MS/MS peptide identification

Mass spectrometry-based proteomics generates vast amounts of signal data that require computational interpretation to obtain peptide identifications. Dozens of algorithms for this task exist, but all exploit only part of the acquired data to judge a peptide-to-spectrum match (PSM), ignoring important information such as the observed retention time and fragment ion peak intensity pattern. Moreover, only few identification algorithms allow open modification searches that can substantially increase peptide identifications. We here therefore introduce ionbot, a novel open modification search engine that is the first to fully merge machine learning with peptide identification. This core innovation brings the ability to include a much larger range of experimental data into PSM scoring, and even to adapt this scoring to the specifics of the data itself. As a result, ionbot substantially increases PSM confidence for open searches, and even enables a further increase in peptide identification rate of up to 30% by also considering highly plausible, lower-ranked, co-eluting matches for a fragmentation spectrum. Moreover, the exclusive use of machine learning for scoring also means that any future improvements to predictive models for peptide behavior will also result in more sensitive and accurate peptide identification.