scholarly journals A pilot study of circulating levels of TGF-β1 and TGF-β2 as biomarkers of bone healing in patients with non-hypertrophic pseudoarthrosis of long bones

Bone Reports ◽  
2022 ◽  
Vol 16 ◽  
pp. 101157
Author(s):  
Daniel Chaverri ◽  
Daniel Vivas ◽  
Santiago Gallardo-Villares ◽  
Fernando Granell-Escobar ◽  
Javier A. Pinto ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bone Healing ◽  
Long Bones ◽  
Circulating Levels ◽  
Tgf Β1

scholarly journals The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence

2020 ◽  
Vol 7 (1) ◽  
pp. 22
Author(s):  
Giuseppe Marongiu ◽  
Andrea Contini ◽  
Andrea Cozzi Lepri ◽  
Matthew Donadu ◽  
Marco Verona ◽  
...  
Keyword(s):  
Systematic Review ◽  
Growth Factors ◽  
Bone Healing ◽  
Healing Process ◽  
Bone Matrix ◽  
Femoral Fractures ◽  
Current Evidence ◽  
Long Bones ◽  
Cell Therapies ◽  
Diaphyseal Fractures

Background: The healing of long bones diaphyseal fractures can be often impaired and eventually end into delayed union and non-union. A number of therapeutic strategies have been proposed in combination with surgical treatment in order to enhance the healing process, such as scaffolds, growth factors, cell therapies and systemic pharmacological treatments. Our aim was to investigate the current evidence of bone healing enhancement of acute long bone diaphyseal fractures. Methods: A systematic review was conducted by using Pubmed/MEDLINE; Embase and Ovid databases. The combination of the search terms “long-bones; diaphyseal fracture; bone healing; growth factors; cell therapies; scaffolds; graft; bone substitutes; orthobiologics; teriparatide”. Results: The initial search resulted in 4156 articles of which 37 papers fulfilled the inclusion criteria and were the subject of this review. The studies included 1350 patients (837 males and 513 females) with a mean age of 65.3 years old. Conclusions: General lack of high-quality studies exists on the use of adjuvant strategies for bone healing enhancement in acute shaft fractures. Strong evidence supports the use of bone grafts, while only moderate evidence demineralized bone matrix and synthetic ceramics. Conflicting results partially supported the use of growth factors and cell therapies in acute fractures. Teriparatide showed promising results, particularly for atypical femoral fractures and periprosthetic femoral fractures.

scholarly journals Effects of Probiotic Supplementation on TGF-β1, TGF-β2, and IgA Levels in the Milk of Japanese Women: An Open-Label Pilot Study

2019 ◽  
Vol 6 ◽  
Author(s):  
Tomoki Takahashi ◽  
Hirofumi Fukudome ◽  
Hiroshi M. Ueno ◽  
Shiomi Watanabe-Matsuhashi ◽  
Taku Nakano ◽  
...  
Keyword(s):  
Pilot Study ◽  
Japanese Women ◽  
Open Label ◽  
Probiotic Supplementation ◽  
Tgf Β1

scholarly journals The Difference between Growth Factor Expression after Single and Multiple Fractures: Preliminary Results in Human Fracture Healing

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Harald Binder ◽  
Stefan Eipeldauer ◽  
Markus Gregori ◽  
Leonard Höchtl-Lee ◽  
Anita Thomas ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Healing ◽  
Transforming Growth Factor ◽  
Serum Levels ◽  
Long Bone ◽  
Long Bones ◽  
Serum Concentrations ◽  
Multiple Fractures ◽  
Fracture Group ◽  
Significant Difference

Objectives.Circulating levels of VEGF-A (Vascular Endothelia Growth Factor-A), TGF-β1 (Transforming Growth Factor-beta 1), and M-CSF (Macrophage-Colony Stimulating Factor) were found to be predictors of bone healing and therefore prognostic criteria of delayed bone healing or nonunion. The aim of this study was to evaluate a potential rise of these markers in patients with multiple fractures of long bones compared to patients with single fractured long bone.Methods.92 patients were included in the study and finally after excluding all female patients 45 male patients were left for final analysis and divided into the single or multiple fracture group. TGF-β1, M-CSF, and VEGF-A serum levels were analysed over a time period of two weeks.Results.MCSF serum concentrations were higher in the group with multiple fractures as also TGF-β1 serum concentrations were at one and two weeks after trauma. No statistically significant difference was observed in the VEGF-A serum concentrations of both groups at either measurement point.Conclusion.We did observe a correlation between the quantity of the M-CSF and TGF-β1 expressions in serum and the number of fractured bones; surprisingly there was no statistically significant difference in the serum levels between patients with single and multiple fractures of long bones.

Evaluation of bone healing with eggshell-derived bone graft substitutes in rat calvaria: A pilot study

2008 ◽  
Vol 87A (1) ◽  
pp. 203-214 ◽  
Author(s):  
Jin-Woo Park ◽  
Sang-Ryul Bae ◽  
Jo-Young Suh ◽  
Dong-Hee Lee ◽  
Sang-Hyun Kim ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bone Graft ◽  
Bone Healing ◽  
Rat Calvaria ◽  
Bone Graft Substitutes

scholarly journals HIGH CIRCULATING LEVELS OF INTERLEUKIN-10 BUT NOT TGF-β1 CHARACTERISE 'TOLERANT' LIVER ALLOGRAFT RECIPIENTS

1999 ◽  
Vol 28 (5) ◽  
pp. 579
Author(s):  
M J Hussain ◽  
N Shaikh ◽  
R Francavilla ◽  
N Heaton ◽  
R Williams ◽  
...  
Keyword(s):  
Interleukin 10 ◽  
Liver Allograft ◽  
Circulating Levels ◽  
Tgf Β1
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