Features of the morphological structure of the placenta in pregnant women with preeclampsia

To study morphological features of the placenta in women in labor, pregnancy which complicated by preeclampsia we studied 26 placentae, of which 17 were from pregnant women with mild to moderate preeclampsia (basic group) and 9 from healthy women (control group). Histologically the study was conducted with methodically recommendations of T.D. Zadorozhnaya et al. for light microscopy. During the study of morphological features of the placenta in women in labor with preeclampsia were installed morphological changes in the placenta, which reflect a tendency to develop compensatory-adaptive reactions following their stress and exhaustion, which is a sign of placental insufficiency. Received data allow claiming a high frequency of development placental insufficiency in pregnant women with risk factors such as chronic salpingo-oophoritis, anemia, late preeclampsia, and inflammation diseases kidney.

New approaches to the treatment of endometrial pathology in patients with extragenital diseases

With purpose to increase efficiency and decrease frequencies of complications after treatment of endo- and myometrium pathology in patients of the perimenopausal period with extragenital pathology this study has been conducted. Different conducted clinic-laboratory, instrumental and pathology examination were performed. 130 patients of the perimenopausal period from somatic pathology (46-60 years) were divided into representative groups. The main group consisted of 100 patients who suffered from endometrium hyperplasia and adenomyosis. The control group included 30 healthy women without pathology of endoand myometrium. Patients of the main group, depending on the applied treatment-and-prophylactic approach, were divided into two subgroups. Group I included 50 women who underwent hysteroscopy and intrauterine cryosurgery, magnesium supplements, and thromboembolic complications (TEC) prevention measures. Patients of the II group (50 patients) underwent hysteroscopy and treatment and prevention measures following the recommendations of the Protocol of the Ministry of Health of Ukraine (№ 676 of 31.12.2004). T he effectiveness of the proposed approach to diagnosis, minimally invasive treatment (hysteroscopy and intrauterine cryosurgery), and prevention of TEC and inflammatory complications of endo pathology- and myometrium in patients of the perimenopausal period with extragenital pathology, according to the clinic-laboratory and cytomorphological examination, the results of ultrasound was 82.0 %, prevention of TEC and inflammatory complications — 100 % cases. According to generally accepted approaches, the effectiveness of treatment was 36.0 %, TEC prevention — 96.0 %, prevention of inflammatory complications — 78.0 %.

Estimation Of Pathomorphological Peculiarities Of Perivulnar Tissue After Ultrasonic Curettage Of Pilonidal Cysts Of Sacro-Coccygeal Region

The results of morphological research of operative wound’s tissue after ultrasonic curettage of acute pilonidal abscess are presented in the article. 13 patients were treated using the offered method, and of these, 11 patients underwent morphological research of the wound’s walls. Areas of the mucoid degeneration of the fibrous connective tissue and fragments of coagulation necrosis were identified, as a result of low-frequency ultrasound. The morphological substrates of recurrence pilonidal sinus, such as stratified squamous epithelium and hair follicles, were not found in any preparation, The offered method of treatment allows for ambulatory primary radical treatment in theacute stage of pilonidal illness. The offered method of ultrasonic curettage of the pilonidal sinus requires more scientific research and monitoring.

Nasal cavity leiomyoma Case report and literature review

Іn this article we discussed the clinical case of leiomyoma of the lower nasal cavity. This pathology is exceptionally rare in such anatomical area, thus examination of current case is very important for medical practitioners. Often this diagnosis can be established intraoperative or after the results of morphological examination. The experience of our clinical case review can assist our colleagues in making a diagnosis at the patient primary examination stage. We also reviewed existing publications on this topic to find common features and differences in patients with this pathology.

Optimization of postpartum management in women with physiological childbirth

Aim of study was to reduce the frequency of inflammatory complications by optimizing therapeutic approaches during the postpartum period. 150 patients were examined after physiological delivery (main group) and divided into two study groups (I and II). The first group included 100 postpartum patients who took probiotics for 1 month, beginning 3–5 days after delivery. The second group consisted of 50 postpartum patients who were not prescribed probiotics. The control group included 50 patients of reproductive age. The probiotic used in the experiment is the drug PROBEEZ® FEMINA. The materials used for the immunological study were washings of cervical mucus.

Morphological features of secondary lung tuberculosis in HIV-patients

In modern conditions, socially dangerous diseases (tuberculosis, HIV infection) are characterized not only by a high level of epidemiological indicators, but also by profound changes in the pathogens themselves (multiple drug resistance, etc.), changes in the course of diseases, its’ complications, causes of death, clinical and morphological manifestations, the appearance of co-infections, which is regarded as a negative phase of pathomorphosis or as reversion. At the same time, the pathomorphosis of diseases significantly complicates their diagnosis. There are objective reasons that do not allow to verify certain nosological units. Under conditions of nosomorphosis due to changes in the biological properties of the pathogen and reactive properties of the organism, in clinical practice and in the study of sectional, surgical and biopsy materials often have difficulties in diagnosis of various forms of tuberculosis and HIV, patho-, morpho- and thanatogenesis. Untimely diagnosis often leads to disability and mortality of patients. Therefore, in clinical practice, undiagnosed forms of socially dangerous diseases are more common. In 2018 251,000 people who had both TB and HIV are estimated to have died1. This is in addition to the 1.2 million people who died from TB alone. A total of 477,461 TB cases among HIV positive people were reported in 2018 (56% of the estimated incidence of 862,000 cases)2. Of these 86% were on antiretroviral therapy. In comparison, in Ukraine in 2019 5943 HIV deaths were reported, 1448 among them had TB and HIV coinfection (24.36%) and 811 of them were on antiretroviral therapy (56%). Due to all these statistics we can make a conclusion that TB in HIV patients is one the main causes of death in HIV-patients. Furthermore, due to the statistics even antiretroviral therapy does not have great affection on the TB and HIV coinfection course. TB/HIV coinfection is a global substantial problem and it means that all international guidelines have to be better implemented.

Morphometric features of blood vessels in adenomas and carcinomas of the parathyroid gland

In this article discussed the problem of neoangiogenesis in neoplastic processes of the parathyroid gland. Applying morphometric methods for the assessment of sectional tissue samples of patients with adenoma and carcinoma of the parathyroid gland, we obtained the results of quantitative and qualitative vascular growth during neoangiogenesis. At present, there are not many studies that assess vascular factor in parathyroid cancer. This study may be useful in research cancer treatment, as it highlights the pathological aspects of the formation of new blood vessels, which is similar in all malignant processes.

The role of chronic endometritis in development of infertility in terms of etiological factors

Chronic endometritis (CE) is a persistent inflammation of the inner lining of the uterine cavity caused by bacteria such as Enterococcus, Streptococcus, Staphylococcus, Enterobacteriaceae. A majority of CE produces no signs or sometimes mild symptoms, and the prevalence rate of CE is 10-15%. Several studies have shown that it is a condition frequently associated with repeated unexplained implantation failure at in vitro fertilization, recurrent miscarriage, as well as preterm labor. In this study, we reviewed how chronic endometritis plays an important role in the development of infertility. Also, we discuss the importance of hysteroscopic procedures in the diagnosis of chronic endometritis.

CLINICAL CASE OF SQUAMOUS CELL CARCINOMA OF OVARIAN DERMOID CYST

Cases of squamous cell carcinoma of the dermoid cyst of the ovaries are rare in comparison with other pathological processes of the ovaries, which is why they are of great interest not only to medical scientists who face such cases, but also for targeted medical cooperation. We review the literature, publications and one clinical case so that specialists who come into contact with it have a clearer idea of ​​the course of the disease, its morphological aspects, which in the future will facilitate the diagnosis. The problem of this pathology is an example of discussion, and therefore the number of scientific works of our foreign colleagues is devoted to it.

Histological and morphometrical features of endometrial polyposis complicated with uterus bleeding. Review and clinical data

Endometrial polyposis is a condition that affects the lining of the endometrium or the uterus and it is seen in 1-17% of women in their reproductive years. The symptoms are often uterine bleeding which can occur as menorrhagia and the polyps can be sessile or pedunculated. This pathology can also arise in women who are in the post-menopausal phase and the exact pathogenesis of the pathology is not known but there are theories that shed light on how this may occur. We conducted a study in which we took 70 surveyed women with endometrial polyps which were complicated by uterine bleeding to determine their morphological types and identify the relationship between the types of polyps and the frequency of uterine bleeding.