adhesion stability
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2021 ◽  
pp. 131316
Author(s):  
Mingjie Li ◽  
Wenxin Luo ◽  
Haoyang Sun ◽  
Jingfu Xu ◽  
Yi Liu ◽  
...  


2021 ◽  
pp. 132250
Author(s):  
Kihoon Jeong ◽  
Yujin Lee ◽  
Youson Kim ◽  
Hyeonwoo Mun ◽  
Ki-Uk Kyung ◽  
...  


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sara Garcia-Garcia ◽  
Maria Rodrigo-Faus ◽  
Noelia Fonseca ◽  
Sara Manzano ◽  
Balázs Győrffy ◽  
...  

AbstractMetastasis is the process of cancer cell dissemination from primary tumors to different organs being the bone the preferred site for metastatic homing of prostate cancer (PCa) cells. Prostate tumorigenesis is a multi-stage process that ultimately tends to advance to become metastatic PCa. Once PCa patients develop skeletal metastases, they eventually succumb to the disease. Therefore, it is imperative to identify essential molecular drivers of this process to develop new therapeutic alternatives for the treatment of this devastating disease. Here, we have identified MAP4K4 as a relevant gene for metastasis in PCa. Our work shows that genetic deletion of MAP4K4 or pharmacological inhibition of its encoded kinase, HGK, inhibits metastatic PCa cells migration and clonogenic properties. Hence, MAP4K4 might promote metastasis and tumor growth. Mechanistically, our results indicate that HGK depleted cells exhibit profound differences in F-actin organization, increasing cell spreading and focal adhesion stability. Additionally, HGK depleted cells fails to respond to TNF-α stimulation and chemoattractant action. Moreover, here we show that HGK upregulation in PCa samples from TCGA and other databases correlates with a poor prognosis of the disease. Hence, we suggest that it could be used as prognostic biomarker to predict the appearance of an aggressive phenotype of PCa tumors and ultimately, the appearance of metastasis. In summary, our results highlight an essential role for HGK in the dissemination of PCa cells and its potential use as prognostic biomarker.



BioResources ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. 3235-3254
Author(s):  
Fan Kang ◽  
Zede Yi ◽  
Bo Zhao ◽  
Zhiyong Qin

In this study, a superhydrophobic wood surface was prepared with amino-functionalized nano-silica (SiO2) particles, epoxy resin (EP) of different curing times, and octadecyltrichlorosilane (OTS). The micro-nano structures of the wood samples were represented by scanning electron microscopy (SEM), while the hydrophobicity and durability of the hydrophobic effect was shown by the contact angle (CA) tests. The results indicated that the optimal curing time of EP was 4 h, such that the wood surface exhibited promising superhydrophobicity with a static CA of 155.4° and a sliding angle (SA) of 3.9°. The different curing time of EP had a remarkable influence on the roughness and the pore structure type of superhydrophobic wood surface. In terms of the Cassie-Baxter theory, the increase of CA on the wood surface was ascribed to the presence of secondary air pores and rough structure in the solid-liquid interface. The obtained wood surface not only possessed excellent adhesion stability and anti-aging properties, but also a resistance to acidic solutions, organic solvents, and mechanical abrasion.



2021 ◽  
Vol 405 ◽  
pp. 126542
Author(s):  
P.P. Jing ◽  
D.L. Ma ◽  
Y.L. Gong ◽  
X.Y. Luo ◽  
Y. Zhang ◽  
...  


Vacuum ◽  
2020 ◽  
Vol 180 ◽  
pp. 109591 ◽  
Author(s):  
Gong Cheng ◽  
Yuqing Xiong ◽  
Hui Zhou ◽  
Kaifeng Zhang ◽  
Kun Li


Soft Matter ◽  
2020 ◽  
Vol 16 (3) ◽  
pp. 709-717 ◽  
Author(s):  
Heng-Wei Zhu ◽  
Jia-Nan Zhang ◽  
Pei Su ◽  
Tianqi Liu ◽  
Changcheng He ◽  
...  

PVA–glycerol gels, which were adhered onto metal substrates by using adhesives, were employed as robust antifouling coating materials. The adhesion stability and antifouling performances of the hydrogel coating against barnacles were investigated.



2020 ◽  
Vol 8 (37) ◽  
pp. 19533-19543 ◽  
Author(s):  
Wei Li ◽  
Qiong Ma ◽  
Xiao Wang ◽  
Xiao-shan Chu ◽  
Fei Wang ◽  
...  

Enhancing the adhesion stability of the anatase TiO2 cocatalyst on the three-dimensional macroporous g-C3N4/GO skeleton for highly efficient hydrogen evolution.



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