scholarly journals Effect of Basketball Sports on Serum Superoxide Dismutase and Its Relationship with the Nanoparticle Drug Delivery System

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jinzhong Wang ◽  
Zhenhua Guo
Keyword(s):  
Drug Delivery ◽  
Superoxide Dismutase ◽  
Drug Delivery System ◽  
Delivery System ◽  
Human Body ◽  
The Body ◽  
Test Model ◽  
Process Data ◽  
Nanoparticle Drug Delivery ◽  
Oxygen Poisoning

Human survival is impossible without oxygen, and as the body load continues to increase, the need for oxygen intake becomes greater. However, oxygen is also a double-edged sword for the human body. A large number of studies have proved that excessive intake of oxygen might lead to oxygen poisoning. Even under normal oxygen uptake, there is still a certain proportion of SOD conversion in oxygen. Superoxide dismutase (SOD) is one of the main causes of oxygen poisoning and chronic diseases. It is of great significance to study the changes of SOD in a large amount of oxygen environment. However, there are a few research studies in this field at home and abroad. Therefore, this paper puts forward the influence of basketball sports on serum superoxide dismutase (SOD) and its relationship with the nanoparticle drug delivery system. The research of this paper is mainly divided into three parts. The first part is the research of theoretical basis and core concepts. Through this part of the study, this paper shows that exercise can make the human body strong, while controlling the transformation of SOD, and only in this way can we achieve the true meaning of sports health. The second part is the establishment method of the test model of the influence of basketball on SOD and the nanoparticle drug delivery system. In this part, the principle and operation steps of the design method are given in detail. In order to ensure the effect of the experiment, the test standard was established, and the whole process data were recorded for the retrospective study. The third part is the comparative experiment, which includes the influence of different exercise intensities on SOD activity and the preservation stability of nanoparticles. Through the analysis of experimental data, it was found that basketball increased the risk of SOD transformation, but at the same time, using nanoparticles intervention can effectively reduce the harm of SOD to the human body.

The Role of Polymer Carrier and Process Parameters for Small Molecule Drug Delivery via Blended Electrospinning

Nano LIFE ◽  
2021 ◽  
Vol 11 (02) ◽  
pp. 2150001
Author(s):  
Yasaman Hamedani ◽  
Murugabaskar Balan ◽  
Soumitro Pal ◽  
Sankha Bhowmick
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fiber Diameter ◽  
The Body ◽  
Small Molecular Weight ◽  
Fibrous Scaffold ◽  
Water Contact ◽  
Polymer Carrier ◽  
Disease Specific

Delivery of therapeutic compounds to the diseased area in the body with minimized adverse effects is the underlying objective behind development of advanced drug delivery systems. Providing disease-specific release patterns is the ultimate goal of any drug delivery system. Electrospinning has been widely used for nanofiber fabrication. Having high aspect ratio and similarity to the extracellular matrix in the body make electrospun nanofibers a great candidate to be used as drug delivery implants. In this study, we report electrospinning to be a tunable technique capable of providing engineered, disease-specific drug release patterns. Using “one factor at a time” and “central composite design” techniques, we respectively demonstrate flow rate and applied voltage to be the two most significant parameters (with [Formula: see text]-values of 512.48 and 42.31) affecting the final fiber diameter, and capillary-to-collector distance as the least important one, by evaluating their influence, individually and combined, on the morphology of electrospun Poly (Lactide-co-Glycolide acid) nanofibers. Using the same two techniques, we also show that hydrophobicity of the polymeric fibrous scaffold, measured by water contact angle (WCA) with the [Formula: see text]-value of 376.44, is the main factor to consider when designing an electrospun fibrous drug delivery system for a specific disease, while fiber diameter can further modulate the release pattern of the drug from hydrophobic polymeric nanofibers. We finally support our hypothesis by comparing our findings with analysis of data derived from the literature. Taken together, our findings suggest electrospinning to be a tunable technique capable of providing various release patterns for any small molecular weight drug on the basis of the requirements of the diseases to be treated.

LECITHINIZED SUPEROXIDE DISMUTASE -AN EFFECTIVE DRUG DELIVERY SYSTEM-

1994 ◽  
pp. 314-315
Author(s):  
R. IGARASHI ◽  
J. HOSHINO ◽  
M. TAKENAGA ◽  
S. KAWAI ◽  
Y. MORIZAWA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Superoxide Dismutase ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug

68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications

2019 ◽  
Vol 107 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Yousef Fazaeli ◽  
Mohammad Amin Hosseini ◽  
Mohammadreza Afrasyabi ◽  
Parviz Ashtari
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Body ◽  
Theranostic Agents ◽  
Diagnostic Applications ◽  
G Ratio ◽  
Mcm 41

Abstract Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reliable approach to deliver theranostic agents into targeted organs. Radiolabeled amorphous silica nanoparticles are of great interest to radiation oncology communities. In order to improve the performance of these nano materials in cancer diagnosis and treatment, their inherent properties, such as surface area and the ability to accumulate in cancer cells, should be enhanced. Pyridine functionalized mesoporous silica MCM-41 is known as a potential anticancer-drug delivery system with high suface area. In thiswork, in order to produce an image-guided drug delivery system for diagnostic applications, [68Ga] radionuclide was grafted on pyridine functionalized MCM-41. The nanoparticles were assessed with atomic force microscopy (AFM), paper chromatography, X-ray diffraction, FTIR spectroscopy, CHN and TGA/DTA analyses. The pharmacokinetic profile evaluation of the radiolabeled nano silica, [68Ga]-Py-Butyl@MCM-41, was done in Fibrosarcoma tumor-bearing mice. This labeled nanocomposite with appropriate blood circulation in body, high structural stability, high tumor/blood ID/g% ratio and fast excretion from the body can be proposed as an efficient nano engineered composite for upcoming tumor targeting/imaging nanotechnology-based applications.

scholarly journals The Impact of Magnesium–Aluminum-Layered Double Hydroxide-Based Polyvinyl Alcohol Coated on Magnetite on the Preparation of Core-Shell Nanoparticles as a Drug Delivery Agent

2019 ◽  
Vol 20 (15) ◽  
pp. 3764 ◽  
Author(s):  
Mona Ebadi ◽  
Kalaivani Buskaran ◽  
Bullo Saifullah ◽  
Sharida Fakurazi ◽  
Mohd Zobir Hussein
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Alcohol ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
The Body ◽  
Normal Fibroblast ◽  
Cellular Environment ◽  
Double Hydroxide ◽  
The Impact

One of the current developments in drug research is the controlled release formulation of drugs, which can be released in a controlled manner at a specific target in the body. Due to the diverse physical and chemical properties of various drugs, a smart drug delivery system is highly sought after. The present study aimed to develop a novel drug delivery system using magnetite nanoparticles as the core and coated with polyvinyl alcohol (PVA), a drug 5-fluorouracil (5FU) and Mg–Al-layered double hydroxide (MLDH) for the formation of FPVA-FU-MLDH nanoparticles. The existence of the coated nanoparticles was supported by various physico-chemical analyses. In addition, the drug content, kinetics, and mechanism of drug release also were studied. 5-fluorouracil (5FU) was found to be released in a controlled manner from the nanoparticles at pH = 4.8 (representing the cancerous cellular environment) and pH = 7.4 (representing the blood environment), governed by pseudo-second-order kinetics. The cytotoxicity study revealed that the anticancer delivery system of FPVA-FU-MLDH nanoparticles showed much better anticancer activity than the free drug, 5FU, against liver cancer and HepG2 cells, and at the same time, it was found to be less toxic to the normal fibroblast 3T3 cells.

scholarly journals EXTRACTION, MODIFICATION, AND CHARACTERIZATION OF NATURAL POLYMERS USED IN TRANSDERMAL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW

2020 ◽  
pp. 10-20
Author(s):  
DIPJYOTI BISWAS ◽  
SUDIP DAS ◽  
SOURAV MOHANTO ◽  
SHUBHRAJIT MANTRY
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Biomedical Application ◽  
The Body ◽  
Fixed Dose ◽  
Natural Polymers ◽  
Transdermal Drug Delivery System

The modified/regulated drug delivery system helps to sustain the delivery of the drug for a prolonged period. The modified drug delivery system is primarily aimed at ensuring protection, the effectiveness of the drug, and patient compliance. The transdermal drug delivery system (TDDS) falls within the modified drug delivery system, in which the goal is to deliver the drug at a fixed dose and regulated rate through the skin. Polymers are the backbone of the framework for providing transdermal systems. The polymer should be stable, non-toxic, economical, and provide a sustainable release of the drug. In general, natural polymers used in the TDDS as rate-controlling agents, protective, and stabilizing agents and also used to minimize the frequency of dosing and improve the drug’s effectiveness by localizing at the site of action. Nowadays, manufacturers are likely to use natural polymers due to many issues associated with drug release and side effects with synthetic polymers. Drug release processes from natural polymers include oxidation, diffusion, and swelling. Natural polymers may be used as the basis to achieve predetermined drug distribution throughout the body. The use of natural materials for traditional and modern types of dosage forms are gums, mucilages, resins, and plant waste etc. Thus, the main objective of this review article is to give a brief knowledge about the extraction, modification, characterization, and biomedical application of conventional natural polymers used in the transdermal drug delivery system and their future prospective.

Trans-meningeal drug delivery to optic nerve ganglion cell axons using a nanoparticle drug delivery system

2014 ◽  
Vol 118 ◽  
pp. 42-45 ◽  
Author(s):  
Karen Grove ◽  
Julia Dobish ◽  
Eva Harth ◽  
Martha-Conley Ingram ◽  
Robert L. Galloway ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optic Nerve ◽  
Ganglion Cell ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nerve Ganglion ◽  
Nanoparticle Drug Delivery

scholarly journals A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

2010 ◽  
Vol 18 (9) ◽  
pp. 1606-1614 ◽  
Author(s):  
Dongmei Sun ◽  
Xiaoying Zhuang ◽  
Xiaoyu Xiang ◽  
Yuelong Liu ◽  
Shuangyin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inflammatory Activity ◽  
Nanoparticle Drug Delivery ◽  
Anti Inflammatory
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