scholarly journals Prevalence of hyperoxemia in hospitals of southern Tamaulipas, Mexico during the period Aug-Oct 2019

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
M A R H Reynaga ◽  
E D C P Castañeda ◽  
L A C M Correa ◽  
E I Z L Zamarrón
Keyword(s):  
Defense Mechanisms ◽  
Population Sample ◽  
Assisted Ventilation ◽  
Lung Damage ◽  
Beneficial Effects ◽  
Male Patients ◽  
Critical Patients ◽  
Clinic Practice ◽  
And Gender ◽  
Oxygen Poisoning

Abstract Background Assisted ventilation represents high benefits for patients that cańt breathe normally or had suffered lung damage. The problem begins when there is an excessive assisted ventilation, that could lead to partial pression of the oxygen that cause hyperoxia and the result is oxygen poisoning [Hyperoxemia]. Reports have shown that cells, connective tissue, and organs can be affected by the hyperoxia. Our research consists in identifying hyperoxemia prevalence in Intensive Care Unit [ICU] at hospitals, so they can develop a better oxygen treatment. Methods The method we use in this investigation were: Nonexperimental, quantitative, retrospective, and transversal research, with the variable data PAO2, PCO2, SO2, age and gender. The subjects were distributed in normoxia and hyperoxemia. The population sample was of 19 patients from the Hospital A, B, and C in the south of Tamaulipas, Mexico, during the August-September 2019 period. The analytic technique used was the statistical average, which was of 137.9% in ICU. Results From 19 patients [100%], 15 patients with hyperoxemia [79%] and 4 patients with normoxemia [21.05%]. There was a difference between hyperoxemia: 10 male patients [52.63%] and 5 female patients [26.31%]. In the ICU, oxygen average saturation was 96.7%, and partial pressure of oxygen was 137.9% Conclusions We recommend performing a blood gas test in each patient with assisted ventilation, this with the purpose of regulate the administration of the oxygen inspiratory rate [FiO2]. Develop a clinic practice manual to regulate the administration of the oxygen inspiratory rate [FiO2] with assisted ventilation patients, with specifications and parameters to use it according each patient's characteristics and noted the consequences of a bad management on this. From 100% of patients [19], 79% [15] had hyperoxemia, which denotes that it is missing health surveillance to look after patient's health in the future. Key messages There are no beneficial effects of hyperoxemia in critical patients clearly demonstrated in clinical trials. The use of elevated FiO2 can produce a direct toxic effect on lung cells, with phenomena of cell destruction and alteration of defense mechanisms.

scholarly journals Antioxidant Strategies and Respiratory Disease of the Preterm Newborn: An Update

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Chiara Poggi ◽  
Carlo Dani
Keyword(s):  
Lung Damage ◽  
Preterm Newborn ◽  
Beneficial Effects ◽  
Melatonin Administration ◽  
Targeted Treatments ◽  
Wide Range ◽  
Nonenzymatic Antioxidants ◽  
Respiratory Outcomes ◽  
Preterm Newborns

Preterm newborns are challenged by an excessive oxidative burden, as a result of several perinatal stimuli, as intrauterine infections, resuscitation, mechanical ventilation, and postnatal complications, in the presence of immature antioxidant capacities. “Oxygen radical disease of neonatology” comprises a wide range of conditions sharing a common pathway of pathogenesis and includes bronchopulmonary dysplasia (BPD) and other main complications of prematurity. Antioxidant strategies may be beneficial in the prevention and treatment of oxidative stress- (OS-) related lung disease of the preterm newborn. Endotracheal supplementation or lung-targeted overexpression of superoxide dismutase was proved to reduce lung damage in several models; however, the supplementation in preterm newborn failed to reduce the risk of BPD, although long-term respiratory outcomes were improved. Also melatonin administration to small cohorts of preterm newborns suggested beneficial effects on lung OS. The possibility to identify single nucleotide polymorphism affecting the risk of BPD may help to identify specific populations with particularly high risk of OS-related diseases and may pose the basis for individually targeted treatments. Finally, surfactant replacement may lead to local anti-inflammatory and antioxidant effects, thanks to specific enzymatic and nonenzymatic antioxidants naturally present in animal surfactants.

scholarly journals What is the prevalence of dyslipidemia in patients with idiopathic tinnitus?

2020 ◽  
Vol 8 (8) ◽  
pp. 2983
Author(s):  
Suleyman Erdogdu
Keyword(s):  
Blood Lipid ◽  
Control Group ◽  
Test Results ◽  
Cochlear Blood Flow ◽  
Number Of Patients ◽  
Significant Difference ◽  
Low Hdl ◽  
Training And Research ◽  
Male Patients ◽  
And Gender

Background: Dyslipidemia is a metabolic disorder that results from imbalanced and overfeeding as well as sedentary life. Elevated blood lipid levels can affect cochlear blood flow and fluidity, leading to decreased hearing and tinnitus. We aimed to determine whether there is a relationship between tinnitus and dyslipidemia by investigating the blood lipoprotein values of patients with tinnitus.Methods: The lipid profiles of the patients with idiopathic tinnitus who were selected among the patients who applied to Istanbul Haydarpaşa Numune Training and Research Hospital with the complaint of tinnitus between January 2019 and May 2020 were examined. The test results and age and gender distributions were compared with control groups without tinnitus complaints and statistical evaluation was performed.Results: Hypercholesterolemia in 42% of 6472 patients with idiopathic tinnitus, 18% low HDL, 50% high LDL, Hyperlipidemia was detected in 21%. 1942 (30%) of these patients were male; 4530 (70%) are women. The number of patients in the control group without tinnitus was 6470. Hypercholesterolemia in 49% of this group; 21% low HDL, 42% high LDL, 16% hyperlipidemia was detected. In this control group, 1950 (30%) of the patients were male and 4520 (70%) were female. Cholesterol of male and female patients with tinnutus. When the cholesterol, LDL and triglyceride values of HDL and LDL values and female and male patients in the control group were examined, a statistically significant difference was found (p <0.005). No statistically significant difference was found between HDL values of female and male patients with tinnutus and HDL values of female and male patients in the control group (P> 0.05).Conclusions: There is a statistically relationship between tinnitus and dyslipidemia. The presence of dyslipidemia is vital due to atherosclerosis caused by dyslipidemia, especially coronary artery involvement. Therefore, dyslipidemia should be treated as it causes many diseases.

scholarly journals The nasopalatine canal and its relationship with the maxillary central incisors: a cone-beam computed tomography study

2021 ◽  
Vol 10 (15) ◽  
pp. e351101522978
Author(s):  
Ana Carolina Neves Melgaço de Lima ◽  
Dominique A. Peniche ◽  
Thais M. C. Coutinho ◽  
Fábio R. Guedes ◽  
Maria Augusta Visconti ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Average Diameter ◽  
Cone Beam ◽  
Nasopalatine Canal ◽  
Gender And Age ◽  
Post Test ◽  
Male Patients ◽  
And Gender ◽  
Student’S T

Objective: To evaluate the dimensions of the nasopalatine canal (NPC) and its relationship with the maxillary central incisors (MCI) using cone-beam computed tomography (CBCT) and to determine variations in the NPC in relation to age and gender. Methods: CBCT scans from 333 patients (67% female; 35.9 ± 14.6 years) were included. The CBCT scan was analyzed to determine the length and diameter of the NPC, the distance between the NPC and the MCI, and to evaluate the morphology of the NPC. The data were analyzed using the independent Student's t-test, the Mann–Whitney and Kruskal–Wallis tests, and Dunn's post-test (p < 0.05). Results: The average diameter and length of the NPC were 2.92 ± 0.91 mm and 12.67 ± 3.32 mm, respectively. The minimum and maximum distance between the MCI and the NPC were 0.78 ± 0.42 mm and 2.56 ± 1.38 mm, respectively. The NPC of male patients was greater in length compared with the female patients (p < 0.05). The majority presented a funnel-like morphology (34.1%), followed by a cylindrical morphology (27.5%). Conclusions: There was variability in the dimensions of the NPC and its relationship with the MCI, which was influenced by gender and age.

Abstract 13626: Human Leukocyte Antigen A*30 is Associated With Congenital Heart Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Horacio G Carvajal ◽  
Fei Wan ◽  
Anoop K Brar ◽  
Chang Liu ◽  
Pirooz Eghtesady
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Large Population ◽  
Population Sample ◽  
Hla Antigens ◽  
Human Leukocyte ◽  
Hla Typing ◽  
Race And Gender ◽  
And Gender

Introduction: Congenital heart disease (CHD) arises from many etiologies, ranging from genetic to environmental exposures, such as viral infections. The human leukocyte antigens (HLA) play an important role in the immune response to pathogens. HLA has been extensively explored and linked with several diseases; no such investigations, however, have been done in context of CHD. Hypothesis: We sought to identify potential HLA associations with CHD in a large population sample with molecular-based HLA typing. Methods: Available data on race, gender, HLA-A, B, and DRB1 typing (1-field, antigen level) was collected from the 2,349 patients in the United Network for Organ Sharing (UNOS) database undergoing heart transplant due to CHD between 2005 and 2017. These were compared to all 80,893 deceased kidney donors in the same period. Nominal variables were compared with Pearson’s chi-square, and logistic regression was used to compare all HLA antigens between groups, adjusting for race and gender. The false discovery rate was used to control for multiple comparisons, with adjusted p-values <0.05 considered significant. Results: There were 14 HLA-A, 25 HLA-B, and 14 HLA-DRB1 antigens with an overall frequency of 1% or higher. The frequency of HLA-A*30, B*44, and DRB1*08 differed significantly between groups (Table 1). Unconditional regression showed significantly increased odds of CHD in patients with HLA-A*30 and HLA-DRB1*08, as well as significantly lower odds in those with HLA-B*44 (Table 1). The demographics between groups were comparable, with the exception of fewer Caucasians in the cases (CHD 60.7% vs controls 65.6%, p=0.026). When adjusted for race and gender, only HLA-A*30 remained statistically significant. Conclusions: HLA-A*30 appears to be linked with CHD independent of race. Further analyses with detailed CHD diagnoses and high-resolution HLA typing data are needed to explore potential associations between specific cardiac defects and HLA at the allele level.

scholarly journals Telescoping and gender differences in the time course of disordered gambling: evidence from a general population sample

Addiction ◽  
2014 ◽  
Vol 110 (1) ◽  
pp. 144-151 ◽  
Author(s):  
Wendy S. Slutske ◽  
Thomas M. Piasecki ◽  
Arielle R. Deutsch ◽  
Dixie J. Statham ◽  
Nicholas G. Martin
Keyword(s):  
Gender Differences ◽  
General Population ◽  
Time Course ◽  
Population Sample ◽  
Disordered Gambling ◽  
General Population Sample ◽  
And Gender

scholarly journals Increased DJ-1 in Urine Exosome of Korean Males with Parkinson’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Dong Hwan Ho ◽  
Sanghak Yi ◽  
Hyemyung Seo ◽  
Ilhong Son ◽  
Wongi Seol
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dependent Manner ◽  
Protein Levels ◽  
Significant Difference ◽  
Daily Dose ◽  
Male Patients ◽  
And Gender ◽  
Urine Exosomes ◽  
Potential Use

Parkinson’s disease (PD) is a difficult disease to diagnose although it is the second most common neurodegenerative disease. Recent studies show that exosome isolated from urine contains LRRK2 or DJ-1, proteins whose mutations cause PD. To investigate a potential use for urine exosomes as a tool for PD diagnosis, we compared levels of LRRK2,α-synuclein, and DJ-1 in urine exosomes isolated from Korean PD patients and non-PD controls. LRRK2 and DJ-1, but notα-synuclein, were detected in the urine exosome samples, as reported previously. We initially could not detect any significant difference in these protein levels between the patient and the control groups. However, when age, disease duration, L-dopa daily dose, and gender were considered as analytical parameters, LRRK2 and DJ-1 protein levels showed clear gender-dependent differences. In addition, DJ-1 level was significantly higher (1.7-fold) in male patients with PD than that in male non-PD controls and increased in an age-dependent manner in male patients with PD. Our observation might provide a clue to lead to a novel biomarker for PD diagnosis, at least in males.

scholarly journals Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Martino Belvederi Murri ◽  
Flaminia Fanelli ◽  
Uberto Pagotto ◽  
Elena Bonora ◽  
Federico Triolo ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Serum Levels ◽  
First Episode Psychosis ◽  
Neuroactive Steroids ◽  
First Episode ◽  
Positive Symptoms ◽  
Symptom Dimensions ◽  
Episode Psychosis ◽  
Male Patients ◽  
And Gender

Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p=0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p=0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.

scholarly journals Impact of Tilapia hepcidin 2-3 dietary supplementation on the gut microbiota profile and immunomodulation in the grouper (Epinephelus lanceolatus)

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chen-Hung Ting ◽  
Chieh-Yu Pan ◽  
Yi-Chun Chen ◽  
Yu-Chun Lin ◽  
Tzong-Yueh Chen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Defense Mechanisms ◽  
Iron Homeostasis ◽  
Expression System ◽  
Feed Conversion ◽  
Sod Activity ◽  
Complement Components ◽  
Regular Diet ◽  
Beneficial Effects ◽  
Immune Related Genes

AbstractHepcidin regulates iron homeostasis and host-defense mechanisms, while the hepcidin-like protein, Tilapia hepcidin (TH)2-3, functions as an antimicrobial peptide (AMP). Since AMP dietary supplements may be used as alternatives to antibiotics in livestock, we tested the effects of recombinant (r)TH2-3 as a dietary supplement in grouper aquaculture. rTH2-3 was produced by a Pichia pastoris expression system and exhibited thermostability and broad-spectrum antimicrobial activity. The feed conversion ratio and feed efficiency were determined in Epinephelus lanceolatus (grouper) fed with rTH2-3-supplemented diet for 28 days. In addition, grouper showed enhanced superoxide dismutase (SOD) activity after rTH2-3 feeding compared to regular-diet-fed fish. Gut microbiota analysis revealed that microbial diversity was enhanced by feeding grouper with 1% rTH2-3. After challenging grouper with Vibrio alginolyticus, differential regulation of immune-related genes in the liver and spleen was observed between the TH2-3 and regular-diet groups, including for genes associated with antimicrobial and pro-inflammatory functions, complement components, and major histocompatibility complex (Mhc). These findings suggest that overall immunity was improved. Thus, our results suggest long-term supplementation with rTH2-3 may be beneficial for aquacultured grouper. The beneficial effects of the supplement are likely based on changes in the commensal microbial community as well as immunomodulation.

scholarly journals Gender and functional outcomes in prestroke depressive patients treated with thrombolytic therapy

2020 ◽  
Vol 15 (2) ◽  
pp. FNL46
Author(s):  
Mandy J Tate ◽  
Rachel M Shugart ◽  
Robyn A Moraney ◽  
Leanne E Brechtel ◽  
Brice Blum
Keyword(s):  
Scale Score ◽  
Functional Outcomes ◽  
Binary Logistic Regression ◽  
Recombinant Tissue Plasminogen Activator ◽  
Lower Serum ◽  
Factors Associated ◽  
Tissue Plasminogen ◽  
Male Patients ◽  
And Gender ◽  
Depressive Patients

Aim: This study investigated the clinical factors associated with functional ambulatory outcomes and gender differences in prestroke depressive patients. Materials & methods: Clinical risk factors associated with improved functional outcomes with recombinant tissue plasminogen activator-treated cohorts were determined using binary logistic regression. Results: In the adjusted analysis, improvement in ambulation was associated with male patients that had higher National Institute of Health stroke scale score (p = 0.04), a stroke history (p = 0.026), lower serum creatinine levels (p = 0.049) and were taking cholesterol reducing medication (p = 0.014). Improvement in females was associated with taking antidepressants (p = 0.027) and having lower National Institute of Health stroke scale score (p = 0.002). Conclusion: Our findings indicate gender disparities between male and female prestroke depressive patients.

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