Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication

Aluminum poisoning has been reported in some parts of the world. It is one of the global health problems that affect many organs. Aluminum is widely used daily by humans and industries. Residues of aluminum compounds can be found in drinking water, food, air, medicine, deodorants, cosmetics, packaging, many appliances and equipment, buildings, transportation industries, and aerospace engineering. Exposure to high levels of aluminum compounds leads to aluminum poisoning. Aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing DNA repair, altering the stability of DNA organization, inhibition of the protein phosphatase 2A (PP2A) activity, increasing reactive oxygen species (ROS) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing NF-kB, p53, and JNK pathway leading to apoptosis. Aluminum poisoning can affect blood content, musculoskeletal system, kidney, liver, and respiratory and nervous system, and the extent of poisoning can be diagnosed by assaying aluminum compounds in blood, urine, hair, nails, and sweat. Chelator agents such as deferoxamine (DFO) are used in the case of aluminum poisoning. Besides, combination therapies are recommended.

TECHNOLOGY AT THE CROSSROADS: A CALL FOR TRANSFORMATIVE TECHNOLOGY IN THE POST-PANDEMIC ERA

Globalization is viewed in this work as a critical concept by which we understand the transition of human society into the post-pandemic era. In this vein, this paper attempts to look into the process of globalization and its central feature, technology. Technology has become a global force that affects political, social, ethical, and environmental. The ancient Greeks, such as Plato and Aristotle, who lived in aristocratic societies, rejected discourse on technology as unworthy. Social, political, and theoretical activities, rather than technical, were deemed as the highest forms. Plato, for instance, alluded to the artisans merely as the cheapest form of metal compared to gold associated with the philosopher-rulers, while silver is equivalent to the warrior class. Technological change, defined as "progress," is seen as an inevitable process in modern history. This paper explored issues of globalization and the implications of technology, employing crucial viewpoints of Martin Heidegger, acknowledged as one of the powerful and influential philosophers of the 20th century. Specifically, this paper explored “machination (Machenschaft)” and Heidegger’s Technik (Technology) or Gestell (Enframing). Machination is not just human conduct but the act of manipulation. It is a revelation of beings as a whole as exploitable and manipulable objects. The world seems to be a collection of present-at-hand thing with no intrinsic meaning or purpose, a cold place where we cannot put down any roots. All we can do is calculate and control. We observe and measure everything. We make things go faster and faster. Thus, there is a need to discuss and recognize issues related to technology. Heidegger's thoughts offer analytic tools that contribute to a critical understanding of the multidimensional effects, risks, and possibilities brought about by modernity and its globalization..

Selection of the Optimal Toll Collection System for the Purposes of Sustainable Development of Transport in the Republic of Srpska

Transport system has multiple interactions and multidimensional effects on the environment, by way of, amongst other, land acquisition and urban pollution; on economic development with regard to the GDP growth; as well as on social equity in terms of access, quality of life and health of population. This paper considers the possibility of introducing toll collection in the Republic of Srpska. The goal of the developed model is to increase revenue, which could be directed to the sustainable development of transport in the Republic of Srpska. The selection of a toll collection system has been made taking account of: economic, traffic, technical, organizational and exploitation criteria. Multiple-criteria approach has been applied together with the Analytic Hierarchy Process.

Psychological Distress of International Students during the COVID-19 Pandemic in China: Multidimensional Effects of External Environment, Individuals’ Behavior, and Their Values

The COVID-19 epidemic has had a significant impact on society. In particular, it has had a strong impact on college students, including international students. Through an online questionnaire survey, it is found that the psychological distress experienced by international students is the result of a combination of the external environment (including the lockdown measures, social distancing, and social support) and internal factors such as values and behavior. The analysis shows that the new teaching mode and the corresponding changes in learning behavior are significantly associated with the psychological distress brought about by the COVID-19 epidemic. In addition, the influence of international students’ values also plays a significant role in their psychological distress. Collective values are conducive to the alleviation of psychological distress, while individual values have the opposite effect. At the same time, the study also reveals that if there is sufficient social support, isolation (due to lockdown or social distancing early or later on) is not necessarily directly related to psychological distress. However, only formal social support can effectively alleviate psychological distress, while informal social support does not play a similar role. These conclusions have certain policy significance for the prevention of and response to epidemics in other countries.

Application of Experimental Design Methodologies in the Enantioseparation of Pharmaceuticals by Capillary Electrophoresis: A Review

Chirality is one of the major issues in pharmaceutical research and industry. Capillary electrophoresis (CE) is an interesting alternative to the more frequently used chromatographic techniques in the enantioseparation of pharmaceuticals, and is used for the determination of enantiomeric ratio, enantiomeric purity, and in pharmacokinetic studies. Traditionally, optimization of CE methods is performed using a univariate one factor at a time (OFAT) approach; however, this strategy does not allow for the evaluation of interactions between experimental factors, which may result in ineffective method development and optimization. In the last two decades, Design of Experiments (DoE) has been frequently employed to better understand the multidimensional effects and interactions of the input factors on the output responses of analytical CE methods. DoE can be divided into two types: screening and optimization designs. Furthermore, using Quality by Design (QbD) methodology to develop CE-based enantioselective techniques is becoming increasingly popular. The review presents the current use of DoE methodologies in CE-based enantioresolution method development and provides an overview of DoE applications in the optimization and validation of CE enantioselective procedures in the last 25 years. Moreover, a critical perspective on how different DoE strategies can aid in the optimization of enantioseparation procedures is presented.