Energy Bilocalization Effect and the Emergence of Molecular Functions in Proteins

Proteins are among the most complex molecular structures, which have evolved to develop broad functions, such as energy conversion and transport, information storage and processing, communication, and regulation of chemical reactions. However, the mechanisms by which these dynamical entities coordinate themselves to perform biological tasks remain hotly debated. Here, a physical theory is presented to explain how functional dynamical behavior possibly emerge in complex/macro molecules, thanks to the effect that we term bilocalization of thermal vibrations. More specifically, our approach allows us to understand how structural irregularities lead to a partitioning of the energy of the vibrations into two distinct sets of molecular domains, corresponding to slow and fast motions. This shape-encoded spectral allocation, associated to the genetic sequence, provides a close access to a wide reservoir of dynamical patterns, and eventually allows the emergence of biological functions by natural selection. To illustrate our approach, the SPIKE protein structure of SARS-COV2 is considered.

Study of Structural Irregularities in different Seismic Zones using Response Spectrum Analysis

The Indian Standard code IS-1893: 2002 (Part-I) defines various types of structural irregularities. The code suggests a special approach of study for irregular structures. The earthquake effect leads to the damage the property and many people loss their life. So, we've to understand the structural performance under seismic load before construction. In this study varying plan irregularities which are often inevitable thanks to building requirements and architectural imperatives, and having a serious impact on building costs are investigated. The objective of the project is to carry out Response spectrum analysis of two RCC buildings is to be done in four different seismic zones of India (i.e., Zone-2, Zone-3, Zone-4, Zone-5). ETABS model of G+10 RCC with Varying Geometry plan is considered in this analysis. The analysis is done using Extended Three-Dimensional Analysis of Building System software. Various response parameters like lateral force, story drift, Displacement are often determined. The evaluation of response of structures subjected to lateral loading with the help of frequency and the magnitude of stress resultant, is also included in the scope of this paper. Keywords: Plan irregularity, Vertical geometric irregularities Response spectrum method, ETABS, Structural Irregularities, Lateral Loading, Non-Linear Analysis, Storey Drift, Storey Displacement.

SEISMIC EVALUATION OF HIGH RISE BUILDING WITH VERTICAL IRREGULARITIES BY PUSHOVER ANALYSIS

During earthquake motion. The seismic behavior depends upon the strength, mass, and stiffness are distributed in both horizontal and vertical planes. the buildings structural damage was severe the frame is caused due to the discontinuity in the stiffness mass and strength between the alongside stories. The same type of discontinuity is vertical geometric irregularity which is due to the irregular building configuration in vertical plane so there is to know the seismic response of building modals in different structural irregularities. Non-linear static (pushover analysis) which is used for Investigation. The purpose of study doing nonlinear static (pushover analysis) by conventional design methodology G+12 High rise buildings this work shows seismic performance and behavior of building frame with and without vertical irregularity in terms of base shear, story shear, story displacement the performance point of all models are considered also found that irregularity in assessment of the structure decreases the performance level of building there is also reduces in deformation or displacement of the structure. all the models analyzed by using ETABS and design as per IS 456:200 and 1893:2016

Influence of structural irregularities on seismic performance of RC frame buildings

Irregular building structure is frequently constructed across the globe for fulfilling aesthetic as well as functional requirements. The structures with irregularities are the common building type in earthquake-prone country like Nepal. However, a post-earthquake reconnaissance survey reports revealed the high seismic vulnerability of the building with structural irregularities. In this context, the present study explores the influence of structural irregularities on performance of reinforced concrete (RC) frame structure. To this end, the structural irregularities are created in in the building structures. The geometrical irregularities are created by removing the bays in different floor levels. Likewise, the effect due to mass irregularities are studied by considering the swimming pool and game house at different floor levels. Furthermore, the stiffness irregularities are formulated by removing the building columns at different sections. All these irregularities are studied analytically in finite element program with 3-D structural models. The numerical analysis is done with non-linear static pushover and time history analysis. The results are analyzed in terms of fundamental time period, storey shear, storey displacement, drift and overturning moment. The results indicate that the level of irregularities significantly influenced the behavior of structures.

Infinite Ergodic Walks in Finite Connected Undirected Graphs

The micro-canonical, canonical, and grand canonical ensembles of walks defined in finite connected undirected graphs are considered in the thermodynamic limit of infinite walk length. As infinitely long paths are extremely sensitive to structural irregularities and defects, their properties are used to describe the degree of structural imbalance, anisotropy, and navigability in finite graphs. For the first time, we introduce entropic force and pressure describing the effect of graph defects on mobility patterns associated with the very long walks in finite graphs; navigation in graphs and navigability to the nodes by the different types of ergodic walks; as well as node’s fugacity in the course of prospective network expansion or shrinking.

Performance Based Seismic Assessment of Masonry Infilled RCC Building with Diaphragm Discontinuity

In multistoreyed RCC framed buildings, critical damages are due to seismic ground excitations, which cause catastrophic failuresat the weaker locations. Buildings with two types of structural irregularities namely diaphragm discontinuity and open ground story are considered. Assessment of seismic vulnerability of these buildings is done by using Nonlinear Static Pushover Analysis (NSPA). Performance Based Seismic Design of masonry infilled RCC buildings with two different shape of openings in the diaphragm is considered here with Design Basis Earthquake(DBE) and Maximum Considered Earthquake(MCE) where by selecting appropriate performance criteria in terms of Inter-story drift ratio(IDR) and Inelastic displacement demand ratio(IDDR) are critically observed. The Equivalent Linearization Procedure of Pushover analysis presented in FEMA 440, which is a modification of Capacity Spectrum Method based on ATC-40 guidelines, is performed in ETABS-2016 to study the performance of R.C.C. buildings with diaphragm discontinuity, designed as per IS-1893-2016.

Assessing the efficiency of a complex of geophysical methods of rock mass research under the conditions of an underground mine

Introduction. At present, geophysical methods of rock mass research have found wide application in mining and Earth sciences. They are used to perform prospecting and evaluation work in the massif, namely, to identify structural irregularities, voids and various contact zones of the media with sufficient accuracy. The accuracy of the results obtained depends on the method used in particular conditions, the nature and parameters of the target, the external conditions of the natural experiment, as well as the tasks set in the work. Research methodology. The work included a set of geophysical studies, namely, methods of spectral seismic profiling and GPR in an underground mine. Measurements were made to find different objects at different angles to the object in question in order to determine the distance to it. Research results. As a result of investigating with a complex of geophysical methods, a metal shelf was found under the bulk rock mass and two shelf tiers were subsequently separated when carrying out vertically directed measurements. In the process of searching for the underlying excavation in the massif during vertically directed geophysical measurements, which were carried out in the horizontal excavation 20 meters from the shaft, changes in spectrum density at a depth of about 55 m were detected, which coincides with the actual location of the sought excavation. The results of cavity search in rock mass when making measurements at an angle to the object sought showed that there are no sufficiently clear boundaries and it is impossible to estimate the distance to the cavity in the filled stopes.

Analisis Perpindahan Lateral Struktur Beton Bertulang Pada Bangunan Bertingkat Beraturan dan Ketidak Beraturan Horizontal

The effect of earthquake forces on buildings will certainly be different if applied to regular and irregular buildings. The performance of structures produced in irregular buildings will be different from the performance of irregular building structures for the same load intensity. In the earthquake resistant structure planning regulations, SNI 1726-2012 concerning structural irregularities. Where in this regulation there are two types of structural irregularities namely horizontal structural irregularities and vertical structural irregularities which are then subdivided into several types of irregularity. The study was carried out to compare the results of building structure performance with horizontal irregularity compared to regular buildings as seen from displacement, drift ratio, base shear, performance level based on ATC-40, differences in reinforcement weight. This research resulted in the largest displacement for the x-direction, namely the type A irregular building where it experiences a deviation of 0,49 m difference and for the y-direction of 0,44 m in the type A irregular building Type A. The biggest drift ratio of the x-direction and direction y is a Type B irregular building that is equal to 0,64 m for the x-direction and 0.57 m for the y-direction. The largest base shear occurs in regular buildings with Type B irregular buildings at 16.34%. the level of performance based on ATC-40 for all building models is immidiate occupancy, the biggest reinforcement need is the irregular building model B with a percentage difference of 11,20%.