IMPACT OF DEPRECIATION OF FIXED ASSETS ON FORMATION OF OWN INVESTMENT RESOURCES OF AN ENTERPRISE

Own investment resources of an enterprise mean depreciation charges and net profit spent for development. Modern scientific literature widely discusses the opinion that there is an optimal depreciation policy, which makes it possible to increase own investment resources of an enterprise. Increase of such resources allegedly stimulates accelerated replacement of obsolete equipment. The paper doubts such assessment and substantiates the conclusion that there is no such notion as "optimal depreciation policy" which could increase own investment resources of an enterprise. Investigation of the problem has been carried out on the basis of enterprise work results modeling by linear method of depreciation of fixed assets and by accelerated methods. Depreciation charges and net profit spent for development were used as final performance indicators of an enterprise.

Decentralized and parallel primal and dual accelerated methods for stochastic convex programming problems

We introduce primal and dual stochastic gradient oracle methods for decentralized convex optimization problems. Both for primal and dual oracles, the proposed methods are optimal in terms of the number of communication steps. However, for all classes of the objective, the optimality in terms of the number of oracle calls per node takes place only up to a logarithmic factor and the notion of smoothness. By using mini-batching technique, we show that the proposed methods with stochastic oracle can be additionally parallelized at each node. The considered algorithms can be applied to many data science problems and inverse problems.

The Usefulness of Trivalent Phosphorus for the Synthesis of Dendrimers

Dendrimers are hyperbranched macromolecules, which are synthesized step-by-step by the repetition of a series of reactions. While many different types of dendrimers are known, this review focusses on the use of trivalent phosphorus derivatives (essentially phosphines and phosphoramidites) for the synthesis of dendrimers. The first part presents dendrimers constituted of phosphines at each branching point. The other parts display the use of trivalent phosphorus derivatives during the synthesis of dendrimers. Different types of reactions have been applied to phosphines. The very first examples of phosphorus-containing dendrimers were obtained by the alkylation of phosphines. Then, several families of dendrimers were elaborated by reaction of phosphoramidites. Such a type of reaction is the base of the solid phase synthesis of oligonucleotides; it has been applied in particular for the synthesis of dendrimers constituted of oligonucleotides. Finally, the Staudinger reaction between phosphines and azides afforded different families of dendrimers, and was at the origin of accelerated methods of synthesis of dendrimers. Besides, the reactivity of the P=N-P=S linkages created by this reaction led to very original dendritic structures.

Evidence For COVID-19 Vaccine Deferred Dose 2 Boost Timing

Both Pfizer and Moderna vaccine trials used accelerated methods to achieve rapid FDA approval with minimal and wise compromises. While many established vaccines use boost / dose 2 timings that are typically in the 3 to 120 months range , dose 2 timings for both trials were less than 30 days as part of a crucial effort to rapidly develop a vaccine with significant efficacy. Data from both trials showed excellent dose 1 efficacy; however, neither of the related Safety and Efficacy publications highlighted this dose 1 efficacy excellence.The trials, manufacturing, and distribution programs have rapidly delivered millions of doses to points of care. However, the ability to administer these doses at localities as rapidly as they can be distributed has been shown as the largest current challenge to achieving the widespread vaccination. Improvements could reduce mortality rates that presently exceed 2000 per day, avoid serious cases at a time where hospital census is at full capacity or beyond, and minimize long-term sequelae.This study suggests that it is possible to achieve these and other goals by recognizing the evidence for COVID-19 vaccine deferred boost timing and using a more conventional, decades-tested, boost timing on the order of months. This would enable currently limited US resources to effectively double the population being vaccinated over the next few months, enabling more rapid vaccination of those at highest-risk for severe infections.

Facile syringe filter-enabled bacteria separation, enrichment, and buffer exchange for clinical isolation-free digital detection and characterization of bacterial pathogens in urine

The development of accelerated methods for pathogen identification (ID) and antimicrobial susceptibility testing (AST) for infectious diseases is necessary to facilitate evidence-based antibiotic therapy and reduce clinical overreliance on broad-spectrum...

CURRENT TRENDS IN THE DEVELOPMENT OF TESTING MATERIALS FOR RESISTANCE TO CLIMATIC FACTORS (review) Part 1. Testing of new materials

In the first part of the review, based on the analysis of world experience in conducting climate tests, the main development trends related to the development of new materials are identified, and it is Shown that in parallel with the development of new materials, appropriate methods of climate testing should be developed taking into account previous experience. It is shown that to assess and predict changes in properties of materials over a long operating life tests of materials are required to conduct accelerated methods of building mathematical models of processes of degradation of their properties under the given climatic and operating factors.