This chapter talks about the opening of the Erie Canal in 1825, which connected Buffalo and New York City although they are almost four hundred miles apart. It explains how the canal, which was built to create a navigable east–west waterway from the Great Lakes to the Atlantic Ocean, transformed New York into what became known as the Empire State during the nineteenth century. It also mentions cities of the East Coast and Great Lakes, midwestern farmlands, and Canadian, British, and European port cities where industries soon settled along the thriving waterfronts of Buffalo and New York, making them prosperous centers for manufacturing and trade. The chapter recounts the construction of the interstate highway system, the Saint Lawrence Seaway, that rendered the Erie Canal completely obsolete by the 1950s. It illustrates how Buffalo and New York City struggled to rebuild in the post-industrial era.