From planting to distribution stages, fresh produce can be contaminated by humans, water, animals, soil, equipment and the environment. Produce growers play an essential role in managing and minimizing on-farm food safety risks. Due to an increase in public awareness about produce safety, farmer food safety education has become an important research and extension topic. This review article summarizes findings from publications that have evaluated produce growers’ food safety knowledge and attitudes and the effectiveness of food safety educational programs for growers. A search of online databases, journal archives, conference abstracts, and reference lists of relevant studies was conducted to locate peer-reviewed articles on the topic of produce growers’ food safety knowledge and behavioral change. Study selection criteria included publications published in English, those published between 2000 and 2019, and those with a focus on one of six topics (agricultural water handling; soil amendments; domesticated animal and wildlife management; worker health and hygiene; food safety plans and record-keeping; and cleaning and sanitation). A total of 43 published articles were included in the analysis. Overall, the studies found agricultural water handling and soil amendments were the two least-understood topics by growers, while worker health and hygiene were the most understood. Thirteen studies evaluated food safety educational interventions, and most studies used in-person workshops and self-reported pre- and post-knowledge assessments. Most reported increased knowledge, some reported improved attitudes and perceived behavior control, and only four reported improved behavioral change. Given these studies’ small sample size, many studies did not conduct a statistical analysis of the difference between pre- and post-survey results. This review article provides insights and guidance on the future development of food safety education for growers.