A review on phytoconstituents of marine brown algae

Background From the last few years, the development and discovery of bioactive compounds and their potential properties from marine algae have been enhanced significantly. The coastal area is a huge storehouse for propitious algae. It has been the genuine reality that the consequence of marine algae as a source of different compounds is increasing. Main body Numerous advanced research devices are available for the discovery of synthetic compounds but still many researchers are working on natural bioactive compounds to discover their biological properties, which are useful to society. Marine algae are taking the preponderance of consideration from investigators owing to its phenomenon of biological activity like anti-cancer, anti-viral, cholesterol-reducing, and many more. A variety of compounds are collected from algae with specific purposes as they remain in an extremely ambitious and hard state; this condition is responsible for the synthesis of very particularly effective bioactive compounds. The present article is concentrating on the brown algae of the Gujarat coast, phlorotannins, polyphenol, phytosterol from brown algae, and their various applications. The main importance has been given to the secondary metabolites and various applications of marine brown algae. Conclusion From this review, it can be concluded that the prominent bioactive compounds from brown algae can cure many serious diseases. Besides, the potential biological activities of a special bioactive compound may represent the interest in the industry of pharmaceuticals, cosmeceutical, and functional foods.

Antidiabetic Potential of Marine Brown Algae—a Mini Review

Marine algae are an important source of bioactive metabolites in drug development and nutraceuticals. Diabetes mellitus is a metabolic disorder and the third leading cause of death worldwide due to lifestyle changes associated with rapid urbanization. Due to the adverse side effects of currently available antidiabetic drugs, search for an effective natural-based antidiabetic drug is important to combat diabetes and its complications. Therefore, in lieu with herbal drug development, it is important to find the potential benefits of seaweeds for the management of type 2 diabetes as they are underexplored yet in Sri Lanka. Among the marine seaweeds, natural bioactive compounds are abundant in brown algae with potentials in application as active ingredients in drug leads and nutraceuticals. Bioactive secondary metabolites are derived from numerous biosynthetic pathways of marine algae which contribute to various chemical and biological properties. Phlorotannins present in marine brown algae exhibited antidiabetic activities through different mechanisms such as the inhibitory effect of enzyme targets mainly by inhibiting the enzymes such as α-amylase, α-glucosidase, angiotensin-converting enzymes (ACE), aldose reductase, dipeptidyl peptidase-4, and protein tyrosine phosphatase 1B (PTP 1B) enzyme. In addition, phlorotannins derived from brown algae have the ability to reduce diabetic complications. Hence, the present review focuses on the different antidiabetic mechanisms of secondary bioactive compounds present in marine brown algae.

Diterpenes From the Marine Brown Algae of the Genus Dilophus

Brown algae of the genus Dilophus contain plenty of biologically active secondary metabolites with diverse structures. Excellent progress has been made in the discovery of diterpenes with extensive chemical defense activity from this genus. Most of these diterpenes exhibit significant biological activities, such as antifungal, cytotoxic, and feeding-deterrent activities. In the present review, we summarized diterpenes isolated from the brown algae of the genus Dilophus.

Immune stimulatory and anti-HIV-1 potential of extracts derived from marine brown algae Padina tetrastromatica

BackgroundMarine brown algae are biologically diverse and their medicinal value has been explored limited. We assessed whether Padina tetrastromatica Hauck will possess the immune stimulatory and human immunodeficiency virus (HIV-1) inhibitory activity.Materials and MethodsAqueous and methanolic extracts were tested for the Th1/Th2 cytokines using PBMC. Subsequently, leukotriene B4 (LTB4), nitric oxide (NO) and anti-oxidant effect were analyzed using RAW264.7 cells. In addition, Padina extracts were tested for the HIV-1 clade C & A by measuring the levels of viral p24 antigen in infected peripheral blood mononuclear cells (PBMCs) and against reverse transcriptase (RT).ResultsAt 100 μg/mL, aqueous and methanolic extracts produced a significant amount of IL-10 and IFN-γ at 24 h and 72 h post-stimulation by PBMCs. It also produced a significant amount of LTB4, NO and had an antioxidant effect on RAW264.7 cell, suggesting the immune stimulating potential of P. tetrastromatica. Upon infection of PBMCs with 100 TCID50, aqueous and methanolic extracts of P. tetrastromatica inhibited HIV-1 C (>90%) and HIV-1 A (>50%) showed a significant reduction in HIV-1 p24 levels and HIV-1 RT inhibition (>50%). GC-MS study revealed a relative abundance of tetradecanoic and oleic acid in the methanolic extract of P. tetrastromatica, which might be responsible for immune stimulation and anti-HIV-1 activity.ConclusionAt lower concentrations (100 mg/mL), the aqueous and methanolic extracts of P. tetrastromatica showed the strong immune stimulation and greatest anti-HIV-1 potential in vitro. This study demonstrates the therapeutic potential of these brown algae P. tetrastromatica for the benefit of mankind.

Fucoxanthin activities motivate its nano/micro-encapsulation for food or nutraceutical application: a review

Fucoxanthin is a xanthophyll carotenoid abundant in marine brown algae, encapsulated fucoxanthin could facilitate the commercialization of orally-deliverable tumor intervention products based on nano/micro-encapsulation technology.

Durability Properties on Marine Algae Concrete

Investigation of marine algae had its progress, due to chemical reaction with cement as a result nature gets affected by contamination and thus the inclusion of algae in the concrete found to control the destructive reactions. Algae are natural congenial which adds to the monetary of the concrete and, in the meantime, there is a decline of the wastes. Durability of concrete assumes an essential job in concrete structures. Durability of concrete might be characterized as the capacity of cement to withstand weathering activity and acid attack by retaining its ideal building properties. There are different materials utilized in the concrete to increase durability property. In this investigation, marine brown algae was utilized as added substance with concrete. A fixed water to cement ratio (W/C = 0.5) for M25 grade concrete was adopted with different marine brown algae percentages at 2%, 5% and 8%. The outcome demonstrates that 8% marine algae concrete performed well when contrast with traditional concrete. Deflection behaviour test established that thecrucial load limit of ideal mix concrete slab was found to be higher than the customary conventional concrete slab.