A Fuzzy Mathematical Model for the Parathyroid Hormone Measurements using Frechet Distribution

In this paper, a fuzzy mathematical model using Frechet distribution was developed and its survival rate function and hazard rate function are used to find the usefulness of a rapid immunometric assay for intraoperative parathyroid hormone measurements.

Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion

Background Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionarily conserved and expressed widely throughout the organism. Loss-of-function AIP mutations predispose to young-onset pituitary adenomas. AIP co-localizes with growth hormone in normal and tumorous somatotroph secretory vesicles. AIP protein is detectable in circulation. We aimed to investigate possible AIP and GH co-secretion, by studying serum AIP and GH levels at baseline and after GH stimulation or suppression, in GH deficiency (GHD) and in acromegaly patients. Subjects and methods Insulin tolerance test (ITT) was performed in GHD patients (n = 13) and age-BMI-matched normal GH axis control patients (n = 31). Oral glucose tolerance test (OGTT) was performed in active acromegaly patients (n = 26) and age-BMI-matched normal GH axis control patients (n = 18). In-house immunometric assay was developed for measuring circulating AIP. Results Serum AIP levels were in the 0.1 ng/mL range independently of gender, age or BMI. Baseline AIP did not differ between GHD and non-GHD or between acromegaly and patients with no acromegaly. There was no change in peak, trough or area under the curve during OGTT or ITT. Serum AIP did not correlate with GH during ITT or OGTT. Conclusions Human circulating serum AIP in vivo was assessed by a novel immunometric assay. AIP levels were independent of age, sex or BMI and unaffected by hypoglycaemia or hyperglycaemia. Despite co-localization in secretory vesicles, AIP and GH did not correlate at baseline or during GH stimulation or suppression tests. A platform of reliable serum AIP measurement is established for further research of its circulatory source, role and impact.

HOMOCYSTEINE STATUS OF ELDERLY SLUM WOMEN IN DELHI

Objective: The study was undertaken to assess homocysteine levels among economically deprived elderly women in Delhi.Methods: The study was carried out among elderly women aged 60–70 years residing in Kirti Nagar slums of West Delhi. Blood samples were collected, and serum homocysteine was analyzed using chemiluminescent immunometric assay. Hyperhomocysteinemia was defined as serum homocysteine >15 μmol/l. Dietary information was also collected using 24 h dietary recall method and food frequency questionnaire.Results: The prevalence of hyperhomocysteinemia was 16.9%. The mean serum homocysteine was 12.35±6.43 μmol/l. Serum homocysteine levels ranged from 3.84 to 35.20 μmol/l. It was observed that hyperhomocysteinemia was higher in vegetarians (31.2%) compared to non-vegetarians (6.7%).Conclusion: The prevalence of hyperhomocysteinemia is higher among vegetarians than non-vegetarians. Further, research is necessary to see the effect of elevated homocysteine in multiple age-related diseases.