What is It Like To Be a Bat in the Time of Covid-19, or How Many Pandemics Could We Have?

In these paired years (2020–2021), the whole world has been impacted by the Covid-19 pandemic, which has resulted in the emergence of different presumptions, alternative facts, and fake news. Among those, the most dominant news was about bats as the culprits of expansion of the virus and, indirectly, the Chinese diet as the root cause. However, there is no proof that the links in the triangle of bat-virus-human are valid; and the source of infection has not been identified. In addition to bats, these viruses can be found in other animals, such as camels, pangolins, and humans. Therefore, individual scientists are reversing the situation by presenting the possibility of transmitting the virus from humans to animals. Nevertheless, it has become ultimately ‘acceptable’ to demonise the bat. In this respect, various authors remind us of certain historical contexts of notions and perceptions of the bats, as well as the similarities and differences of those perceptions during the pandemic, referring to it mainly in the context of Croatia and the world. In the end, the article’s conclusion is that the story about the bats is, actually, a great indicator of the representations of Otherness and the strengthening of a binary and hierarchical division of ‘us’ and ‘them’.

SUSTAINBLE DEVELOPMENT AND THE EDUCATION TO COMBAT EPIDEMIC IN ‎"L'ANNÉE DU LION" OF DEON MEYER

Several years ago, before the emergence of the Corona virus that continues to ‎sweep the world. A south African writer Deon Meyer predicts the coming of a virus ‎that will kill 95% of the world's population.‎ This virus is a mixture of a human virus and a bat virus. It is almost the same thing ‎we are experiencing right now.‎ Our work is based on a study of the story " L'Année Du Lion".‎ We focus on the friend ship son father. The education of gaining freedom and ‎courage in the challenge of disease, defending the rights of others for the birth of a ‎multinational society. Our research is divided into two parts.‎ The first part will be about the concept of education in this story and the second part ‎about sustainable development that analyse Deon Meyer‎. Keywords: Sustainble Development, Education, Epidemic.

Variation in synonymous nucleotide composition among genomes of sarbecoviruses and consequences for the origin of COVID-19

The subgenus Sarbecovirus includes two human viruses, SARS-CoV and SARS-CoV-2, respectively responsible for the SARS epidemic and COVID-19 pandemic, as well as many bat viruses and two pangolin viruses.Here, the synonymous nucleotide composition (SNC) of Sarbecovirus genomes was analysed by examining third codon-positions, dinucleotides, and degenerate codons. The results show evidence for the eigth following groups: (i) SARS-CoV related coronaviruses (SCoVrC including many bat viruses from China), (ii) SARS-CoV-2 related coronaviruses (SCoV2rC; including five bat viruses from Cambodia, Thailand and Yunnan), (iii) pangolin viruses, (iv) three bat viruses showing evidence of recombination between SCoVrC and SCoV2rC genomes, (v) two highly divergent bat viruses from Yunnan, (vi) the bat virus from Japan, (vii) the bat virus from Bulgaria, and (viii) the bat virus from Kenya. All these groups can be diagnosed by specific nucleotide compositional features except the one concerned by recombination between SCoVrC and SCoV2rC. In particular, SCoV2rC genomes are characterised by the lowest percentages of cyosine and highest percentages of uracil at third codon-positions, whereas the genomes of pangolin viruses exhibit the highest percentages of adenine at third codon-positions. I suggest that latitudinal and taxonomic differences in the imbalanced nucleotide pools available in host cells during viral replication can explain the seven groups of SNC here detected among Sarbecovirus genomes. A related effect due to hibernating bats is also considered. I conclude that the two independent host switches from Rhinolophus bats to pangolins resulted in convergent mutational constraints and that SARS-CoV-2 emerged directly from a horseshoe bat virus.

A species-specific signature residue in the PB2 subunit of the bat influenza virus polymerase restricts viral RNA synthesis.

Bat influenza A viruses (H17N10 and H18N11) are genetically distant from conventional influenza A viruses and replicates poorly in non-bat hosts species. However, the reason behind the lower replication fitness of these viruses are yet to be elucidated. In this work, we have identified species-specific signature residues, present in viral PB2 protein, which is a major determinant of polymerase fitness in human, avian and bat cell lines. Through extensive sequence and structural comparison between the bat and non-bat influenza virus RNA polymerases, we have identified a previously uncharacterized PB2-282 residue, which is serine in bat virus PB2 protein but harbours highly conserved glutamic acid in conventional influenza A viruses. Introduction of these bat specific signatures in the polymerase of a human adapted strain of influenza A/H1N1 virus drastically reduces its polymerase activity and replication efficiency in cell lines of human, bat and canine origin. In contrast, introduction of the human-specific signatures in bat virus PB2 (H17N10), significantly enhances its function in the context of a chimeric RNA polymerase. Interestingly, the PB2-282 resides within an evolutionary conserved 'S-E-S' motif present across different genera of influenza viruses but is replaced with a 'S-S-T' motif in bat influenza viruses, indicating that this E to S transition may serve as a species-specific adaptation signature that modulates the activity of bat virus polymerase in other host species.

Lagos Bat Virus, an Under-Reported Rabies-Related Lyssavirus

Lagos bat virus (LBV), one of the 17 accepted viral species of the Lyssavirus genus, was the first rabies-related virus described in 1956. This virus is endemic to the African continent and is rarely encountered. There are currently four lineages, although the observed genetic diversity exceeds existing lyssavirus species demarcation criteria. Several exposures to rabid bats infected with LBV have been reported; however, no known human cases have been reported to date. This review provides the history of LBV and summarizes previous knowledge as well as new detections. Genetic diversity, pathogenesis and prevention are re-evaluated and discussed.

Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen

Virus host shifts are generally associated with novel adaptations to exploit the cells of the new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has apparently required little to no significant adaptation to humans since the start of the Coronavirus Disease 2019 (COVID-19) pandemic and to October 2020. Here we assess the types of natural selection taking place in Sarbecoviruses in horseshoe bats versus the early SARS-CoV-2 evolution in humans. While there is moderate evidence of diversifying positive selection in SARS-CoV-2 in humans, it is limited to the early phase of the pandemic, and purifying selection is much weaker in SARS-CoV-2 than in related bat Sarbecoviruses. In contrast, our analysis detects evidence for significant positive episodic diversifying selection acting at the base of the bat virus lineage SARS-CoV-2 emerged from, accompanied by an adaptive depletion in CpG composition presumed to be linked to the action of antiviral mechanisms in these ancestral bat hosts. The closest bat virus to SARS-CoV-2, RmYN02 (sharing an ancestor about 1976), is a recombinant with a structure that includes differential CpG content in Spike; clear evidence of coinfection and evolution in bats without involvement of other species. While an undiscovered “facilitating” intermediate species cannot be discounted, collectively, our results support the progenitor of SARS-CoV-2 being capable of efficient human–human transmission as a consequence of its adaptive evolutionary history in bats, not humans, which created a relatively generalist virus.

Juridical Optics in the Formulation of Execution Application Form Act No. 6 of 2018 concerning Health Quarantine After the End of the Implementation of Large-Scale Social Restrictions and the Imposition of New Normal and Safe Life Coordination Period 19 to Achieve Criminal Justice for Every Indonesian Citizen

World Health Organization (WHO) Director General of the World Health Organization, Tedros Adhanom Ghebreyesus officially announced the Corona virus (Covid 19) as a pandemic on Wednesday, March 11, 2020, so the world community and countries of the world were excited and asked to take steps prevention measures according to the health protocol established by WHO. The WHO reason is that prevention needs to be carried out by world countries, because the Corona Covid 19 Virus pandemic is an infectious disease that spreads easily from human to human in various parts of the world. I do not know, from where the source of this corona virus appears and infects and exposes the virus so that it becomes pandamic and kills many people in the countries of the world so quickly. Citing Worldometers website data, Tuesday (2/6/2020), the number of confirmed cases of corona virus infection globally is 6,358,294 (6.36 million) cases. Meanwhile, the number of deaths recorded was 377,031 cases. While the number of patients recovered as many as 2,888,571 (2.89 million) people. The number of active cases is 3,092,692 (3.09 million) cases, with 3,039,290 (3.04 million) in mild conditions, and 53,402 in serious conditions. Furthermore, the global tragedy to follow up and respond to the insistence of the WHO world health organization, the Indonesian state took anticipatory steps with the congressional movement starting on April 13, 2020, through the President of the Republic of Indonesia Joko Widodo expressly announcing and establishing and stating that the Covid 19 Virus is as a non-natural national disaster spreading Corona Virus Diseasses 2019 (Covid 19) as a national disaster. In order to prevent the exposure or the strongest Covid 19 virus to the people of Indonesia, the government issued Presidential Regulation No. 12 of 2020, and Government Regulation No. 21 of 2020 concerning the implementation of the related large-scale Social Restrictions (hurud b), Article 49 Paragraph (3) and Article 59 of Law Law No. 6 of 2018 concerning Health Qulity. Indonesia did not want to bother, and asked WHO, the results of the Corona Covid 19 virus were accepted, but were more focused on handling the corona virus in the country. Meanwhile, developed countries such as America, Britain, Australia, opposed cool in an opinion war against China, which is associated with several countries Corona Virus came and began to plague in Wuhan, China using the source of infectious diseases through the bat virus. America, can receive that information, namely the President of the United States Donald Trump, accepts anger and sulking, and even has evidence of the results of his intelligence reports related to it, the Corona virus is actually not a virus transmitted from a bat virus to humans, but Donald Trump's presumption , that's the corona virus, originating from chemical laboratories in Wuhan China, which leaked and infected humans and eventually became a plague of infectious viruses throughout the world. Latest information, Britain, Australia, America will file a claim for compensation to the Chinese state through a lawsuit to the International Criminal Court (ICC). Furthermore, to support the objectives of this study, the paradigm used in this study is the post-positivism paradigm. The post-positivism paradigm wants to prove everything is based on reality (which can be built based on experience, observation), the researcher is neutral towards the object of research, even though the researcher holding this paradigm remains neutral towards the object of research, but he wants to examine what actually happened from things the thing that seems certain. The post-positivism paradigm ontologically conceptualizes reality as it really is, but it is realized that there are actually many factors that influence that reality. Consequently, ontologically the post-positivism paradigm conceptualizes the law as a set of rules that apply in society whose behavior will be influenced by factors (economic, political, cultural, etc.). Epistemologically, researchers sit themselves impersonal, separate from the object of research. The researcher's position on the object of research is neutral and impartial.

Characterization of Novel Rhabdoviruses in Chinese Bats

Bats, the second largest order of mammals worldwide, harbor specific characteristics such as sustaining flight, a special immune system, unique habits, and ecological niches. In addition, they are the natural reservoirs of a variety of emerging or re-emerging zoonotic pathogens. Rhabdoviridae is one of the most diverse families of RNA viruses, which consists of 20 ecologically diverse genera, infecting plants, mammals, birds, reptiles, and fish. To date, three bat-related genera are described, named Lyssavirus, Vesiculovirus, and Ledantevirus. However, the prevalence and the distribution of these bat-related rhabdoviruses remain largely unknown, especially in China. To fill this gap, we performed a large molecular retrospective study based on the real-time reverse transcription polymerase chain reaction (RT-qPCR) detection of lyssavirus in bat samples (1044 brain and 3532 saliva samples, from 63 different bat species) originating from 21 provinces of China during 2006–2018. None of them were positive for lyssavirus, but six bat brains (0.6%) of Rhinolophus bat species, originating from Hubei and Hainan provinces, were positive for vesiculoviruses or ledanteviruses. Based on complete genomes, these viruses were phylogenetically classified into three putative new species, tentatively named Yinshui bat virus (YSBV), Taiyi bat virus (TYBV), and Qiongzhong bat virus (QZBV). These results indicate the novel rhabdoviruses circulated in different Chinese bat populations.