How Chemoresistive Sensors Can Learn from Heterogeneous Catalysis. Hints, Issues, and Perspectives

The connection between heterogeneous catalysis and chemoresistive sensors is emerging more and more clearly, as concerns the well-known case of supported noble metals nanoparticles. On the other hand, it appears that a clear connection has not been set up yet for metal oxide catalysts. In particular, the catalytic properties of several different oxides hold the promise for specifically designed gas sensors in terms of selectivity towards given classes of analytes. In this review, several well-known metal oxide catalysts will be considered by first exposing solidly established catalytic properties that emerge from related literature perusal. On this basis, existing gas-sensing applications will be discussed and related, when possible, with the obtained catalysis results. Then, further potential sensing applications will be proposed based on the affinity of the catalytic pathways and possible sensing pathways. It will appear that dialogue with heterogeneous catalysis may help workers in chemoresistive sensors to design new systems and to gain remarkable insight into the existing sensing properties, in particular by applying the approaches and techniques typical of catalysis. However, several divergence points will appear between metal oxide catalysis and gas-sensing. Nevertheless, it will be pointed out how such divergences just push to a closer exchange between the two fields by using the catalysis knowledge as a toolbox for investigating the sensing mechanisms.

Colorectal Cancer Study with Nanostructured Sensors: Tumor Marker Screening of Patient Biopsies

Despite the great progress in screening techniques and medical treatments, colorectal cancer remains one of the most widespread cancers in both sexes, with a high death rate. In this work, the volatile compounds released from human colon cancer tissues were detected by a set of four different chemoresistive sensors, made with a nanostructured powder of metal-oxide materials, inserted into an innovative patented device. The sensor responses to the exhalation of a primary cancer sample and of a healthy sample (both of the same weight, collected during colorectal surgery from the intestine of the same patient) were statistically analyzed. The sensors gave reversible, reproducible, and fast responses for at least one year of continuous use, making them quite superior in respect to the existing diagnostic methods. Preliminary results obtained using principal component analysis of the sensor responses to samples removed from 13 patients indicate that the nanostructured sensors employed in this study were able to distinguish between healthy and tumor tissue samples with coherent responses (the discrimination power of the most sensitive sensor was about 17%), highlighting a strong potential for clinical practice.

Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

Preventive screening does not only allow to preemptively intervene on pathologies before they can harm the host; but also to reduce the costs of the intervention itself; boosting the efficiency of the NHS (National Health System) by saving resources for other purposes. To improve technology advancements in this field; user-friendly yet low-cost devices are required; and various applications for gas sensors have been tested and proved reliable in past studies. In this work; cell cultures and blood samples have been studied; using nanostructured chemoresistive sensors; to both verify if this technology can reliably detect tumor markers; and if correlations between responses from tumor line metabolites and the screening outcomes on human specimens could be observed. The results showed how sensors responded differently to the emanations from healthy and mutant (for cells) or tumor affected (for blood) samples, and how those results were consistent between them, since the tumoral specimens had higher responses compared to the ones of their healthy counterparts. Even though the patterns in the responses require a bigger population to be defined properly; it appeared that the different macro-groups between the same kind of samples are distinguishable from some of the sensors chosen in the study; giving promising outcomes for further research.