Coordination dynamics of multi-agent interaction in a musical ensemble

Humans interact with other humans at a variety of timescales and in a variety of social contexts. We exhibit patterns of coordination that may differ depending on whether we are genuinely interacting as part of a coordinated group of individuals vs merely co-existing within the same physical space. Moreover, the local coordination dynamics of an interacting pair of individuals in an otherwise non-interacting group may spread, propagating change in the global coordination dynamics and interaction of an entire crowd. Dynamical systems analyses, such as Recurrence Quantification Analysis (RQA), can shed light on some of the underlying coordination dynamics of multi-agent human interaction. We used RQA to examine the coordination dynamics of a performance of “Welcome to the Imagination World”, composed for wind orchestra. This performance enacts a real-life simulation of the transition from uncoordinated, non-interacting individuals to a coordinated, interacting multi-agent group. Unlike previous studies of social interaction in musical performance which rely on different aspects of video and/or acoustic data recorded from each individual, this project analyzes group-level coordination patterns solely from the group-level acoustic data of an audio recording of the performance. Recurrence and stability measures extracted from the audio recording increased when musicians coordinated as an interacting group. Variability in these measures also increased, indicating that the interacting ensemble of musicians were able to explore a greater variety of behavior than when they performed as non-interacting individuals. As an orchestrated (non-emergent) example of coordination, we believe these analyses provide an indication of approximate expected distributions for recurrence patterns that may be measurable before and after truly emergent coordination.

Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts

Osteoclasts are unique in their capacity to degrade bone tissue. To achieve this process, osteoclasts form a specific structure called the sealing zone, which creates a close contact with bone and confines the release of protons and hydrolases for bone degradation. The sealing zone is composed of actin structures called podosomes nested in a dense actin network. The organization of these actin structures inside the sealing zone at the nano scale is still unknown. Here, we combine cutting-edge microscopy methods to reveal the nanoscale architecture and dynamics of the sealing zone formed by human osteoclasts on bone surface. Random illumination microscopy allowed the identification and live imaging of densely packed actin cores within the sealing zone. A cross-correlation analysis of the fluctuations of actin content at these cores indicates that they are locally synchronized. Further examination shows that the sealing zone is composed of groups of synchronized cores linked by α-actinin1 positive filaments, and encircled by adhesion complexes. Thus, we propose that the confinement of bone degradation mediators is achieved through the coordination of islets of actin cores and not by the global coordination of all podosomal subunits forming the sealing zone.

Rethinking Global Governance: The replication of “joined-up government” on the global scale in the prevention and combatting of trafficking in women for the purposes of sexual exploitation

<p>The paper discusses the Blair Administration’s policy of “joined-up government” beginning in Britain in 1997. The paper then moves to the international sphere to discuss various anti-slavery instruments focusing on the trafficking in women for the purposes of sexual exploitation. The paper identifies global coordination efforts to prevent and combat trafficking in persons. In particular, the establishment of the Inter-Agency Coordination Group Against Trafficking in Persons in 2007 provides a prime example of such efforts. The paper then describes how the policy of joined-up government has been replicated the global scale. The paper names this phenomenon “globally joined-up governance”.</p>

Rethinking Global Governance: The replication of “joined-up government” on the global scale in the prevention and combatting of trafficking in women for the purposes of sexual exploitation

<p>The paper discusses the Blair Administration’s policy of “joined-up government” beginning in Britain in 1997. The paper then moves to the international sphere to discuss various anti-slavery instruments focusing on the trafficking in women for the purposes of sexual exploitation. The paper identifies global coordination efforts to prevent and combat trafficking in persons. In particular, the establishment of the Inter-Agency Coordination Group Against Trafficking in Persons in 2007 provides a prime example of such efforts. The paper then describes how the policy of joined-up government has been replicated the global scale. The paper names this phenomenon “globally joined-up governance”.</p>

International Coordination of Research Ethics Review: An Adequacy Model

International direct-to-participant (DTP) genomics research involves the use of mobile technology to recruit, consent, and study participants remotely. This model can facilitate research across broad geographies and many countries, but must also comply with the norms of multiple recruitment jurisdictions, with each jurisdiction typically requiring at least one local research ethics review. Each additional research ethics review increases bureaucratic hurdles without necessarily strengthening the protection of participants’ rights and interests. For DTP genomic research, obtaining a review may in fact be impossible in the absence of a local research partner. This paper proposes an “adequacy” approach, inspired by data protection law, to coordinate the regulation and oversight of international DTP genomics research. This involves one country voluntarily assessing whether another country’s research ethics reviews are equivalent to its own, in terms of objectives and effectiveness. Ethics-approved projects led by researchers from countries recognized as adequate are deemed to comply with local norms, eliminating the need for a duplicative local review. Adequacy preserves the sovereignty of countries to determine their own regulatory aims and which other countries to trust. It therefore provides a voluntary, incremental path towards greater global coordination of health research oversight.

Impact of Governmental interventions on epidemic progression and workplace activity during the COVID-19 outbreak

In the first quarter of 2020, the COVID-19 pandemic brought the world to a state of paralysis. During this period, humanity saw by far the largest organized travel restrictions and unprecedented efforts and global coordination to contain the spread of the SARS-CoV-2 virus. Using large scale human mobility and fine grained epidemic incidence data, we develop a framework to understand and quantify the effectiveness of the interventions implemented by various countries to control epidemic growth. Our analysis reveals the importance of timing and implementation of strategic policy in controlling the epidemic. We also unearth significant spatial diffusion of the epidemic before and during the lockdown measures in several countries, casting doubt on the effectiveness or on the implementation quality of the proposed Governmental policies.

Urgent, Comprehensive Federal Action Needed To Stem Mortality and Medicare Costs Associated With Antimicrobial Resistance

This paper is a call to action for the policies necessary to reduce the burden of antimicrobial resistance, including federal investments in antibiotic stewardship, antibiotic innovation, surveillance, research, diagnostics, infection prevention, the infectious diseases workforce, and global coordination.

COVID-19 and Socioeconomic Crises in Africa: Overview of the Prevailing Incidents

The study gives an overview of the socio-economic consequences and implications of the COVID-19 outbreak in Africa. While it is common knowledge that the damage caused by the pandemic to the global economy is real, the existing socio-economic crises in Africa could further degenerate. What remains salient is that the huge economic costs would be borne by regions bereft of strong institutional regulatory setup and proactive approach to effectively ameliorate the impact of the outbreak, in both short-run and long-run, to bounce back in relation to the magnitude of the shocks suffered. It is indeed affirmed that in most sub-Saharan African (SSA) countries, such resilient measures seem to be absent or non-existent. Given the degree of behavioral responses and attendant vulnerabilities generated, African socio-economic problems may be potentially exacerbated with the majority of the population face severe hardships in the continent, as socio-economic conditions could be worsened by the COVID-19 pandemic. Thus, the immediate policy option for African countries is to address the prevalent health challenge in the continent; strengthen health services for effective restructuring; and put in place well-defined stimulus measures to aid in the resurgence of economic growth. Although the use of good and tested vaccines should be encouraged to curb the spread of COVID-19 in Africa, developed countries’ support, and global coordination and cooperation are essential to curtail the economic damage and to facilitate robust recovery and development trajectory globally.

Ethics, Patents and Genome Editing: A Critical Assessment of Three Options of Technology Governance

Current methods of genome editing have been steadily realising the once remote possibilities of making effective and realistic genetic changes to humans, animals and plants. To underpin this, only 6 years passed between Charpentier and Doudna’s 2012 CRISPR-Cas9 paper and the first confirmed (more or less) case of gene-edited humans. While the traditional legislative and regulatory approach of governments and international bodies is evolving, there is still considerable divergence, unevenness and lack of clarity. However, alongside the technical progress, innovation has also been taking place in terms of ethical guidance from the field of patenting. The rise of so-called “ethical licensing” is one such innovation, where patent holders’ control over genome editing techniques, such as CRISPR, creates a form of private governance over possible uses of gene-editing through ethical constraints built into their licensing agreements. While there are some immediately apparent advantages (epistemic, speed, flexibility, global reach, court enforced), this route seems problematic for, at least, three important reasons: 1) lack of democratic legitimacy/procedural justice, 2) voluntariness, wider/global coordination, and sustainability/stability challenges and 3) potential motivational effects/problems. Unless these three concerns are addressed, it is not clear if this route is an improvement on the longer, slower traditional regulatory route (despite the aforementioned problems). Some of these concerns seem potentially addressed by another emerging patent-based approach. Parthasarathy proposes government-driven regulation using the patent system, which, she argues, has more transparency and legitimacy than the ethical licensing approach. This proposal includes the formation of an advisory committee that would guide this government-driven approach in terms of deciding when to exert control over gene editing patents. There seem to be some apparent advantages with this approach (over traditional regulation and over the ethical licensing approach mentioned above—speed and stability being central, as well as increased democratic legitimacy). However, problems also arise—such as a “half-way house” of global democratic legitimacy that may not be legitimate enough whilst still compromising speed of decision-making under the “ethical licensing” approach). This paper seeks to highlight the various advantages and disadvantages of the three main regulatory options—traditional regulation, ethical licensing and Parthasarathy’s approach—before suggesting an important, yet realistically achievable, amendment of TRIPS and an alternative proposal of a WTO ethics advisory committee.

The Role of Blue Carbon in Climate Change Mitigation and Carbon Stock Conservation

The potential for Blue Carbon ecosystems to combat climate change and provide co-benefits was discussed in the recent and influential Intergovernmental Panel on Climate Change Special Report on the Ocean and Cryosphere in a Changing Climate. In terms of Blue Carbon, the report mainly focused on coastal wetlands and did not address the socio-economic considerations of using natural ocean systems to reduce the risks of climate disruption. In this paper, we discuss Blue Carbon resources in coastal, open-ocean and deep-sea ecosystems and highlight the benefits of measures such as restoration and creation as well as conservation and protection in helping to unleash their potential for mitigating climate change risks. We also highlight the challenges—such as valuation and governance—to marshaling their mitigation role and discuss the need for policy action for natural capital market development, and for global coordination. Efforts to identify and resolve these challenges could both maintain and harness the potential for these natural ocean systems to store carbon and help fight climate change. Conserving, protecting, and restoring Blue Carbon ecosystems should become an integral part of mitigation and carbon stock conservation plans at the local, national and global levels.