Optimizing Solvent Selection and Processing Conditions to Generate High Bulk-Density, Co-Precipitated Amorphous Dispersions of Posaconazole

Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs), notable for its ability to enable the production of ASDs containing pharmaceuticals with thermal instability and limited solubility. As is true for spray drying and other unit operations to generate amorphous materials, changes in processing conditions during co-precipitation, such as solvent selection, can have a significant impact on the molecular and bulk powder properties of co-precipitated amorphous dispersions (cPAD). Using posaconazole as a model API, this work investigates how solvent selection can be leveraged to mitigate crystallization and maximize bulk density for precipitated amorphous dispersions. A precipitation process is developed to generate high-bulk-density amorphous dispersions. Insights from this system provide a mechanistic rationale to control the solid-state and bulk powder properties of amorphous dispersions.

Typical debris-flow barrier dams and associated outburst floods in the southeastern Tibet

<p>Large-magnitude debris flows up to a volume of 1.0 million m3 happen frequently in the southeastern margin of Tibetan plateau due to rapid rock uplift, high relief and abundant rainfall. These flows with high bulk density can easily block main rivers. Such debris-flow barrier dams fail very quickly, resulting in outburst floods and intensive sed-iment transport. We collect data of four recent large-scale debris-flow damming events at Peilong, Yigong, Tianmo and Sedongpu catch-ments, and examine the process of riverbank erosion and sediment transportation under dam narrowing and outburst flooding. More than 10% of debris mass was delivered downstream when the dams breached. It is concluded that debris flow is main erosion way in this area, and the very high erosion rate play a key role on river morpholo-gy in southeast Tibet.</p>

Fire and grazing determined grasslands of central Madagascar represent ancient assemblages

The ecology of Madagascar's grasslands is under-investigated and the dearth of ecological understanding of how disturbance by fire and grazing shapes these grasslands stems from a perception that disturbance shaped Malagasy grasslands only after human arrival. However, worldwide, fire and grazing shape tropical grasslands over ecological and evolutionary timescales, and it is curious Madagascar should be a global anomaly. We examined the functional and community ecology of Madagascar's grasslands across 71 communities in the Central Highlands. Combining multivariate abundance models of community composition and clustering of grass functional traits, we identified distinct grass assemblages each shaped by fire or grazing. The fire-maintained assemblage is primarily composed of tall caespitose species with narrow leaves and low bulk density. By contrast, the grazer-maintained assemblage is characterized by mat-forming, high bulk density grasses with wide leaves. Within each assemblage, levels of endemism, diversity and grass ages support these as ancient assemblages. Grazer-dependent grasses can only have co-evolved with a now-extinct megafauna. Ironically, the human introduction of cattle probably introduced a megafaunal substitute facilitating modern day persistence of a grazer-maintained grass assemblage in an otherwise defaunated landscape, where these landscapes now support the livelihoods of millions of people.

A petrographic study of the genesis of anomalous sections in the Bazhenov Formation, the Imilor deposit, Western Siberia

Research subject. Anomalous sections present in the oil- and bituminous-bearing Bazhenov Formation (BF), in the central areas of the West Siberian basin, are considered to have emerged due to the injection of plastic pulp masses from the sedimentation slope into weakly lithified basal deposits. The aim of this research was to evaluate the as-emerged rocks by analyzing their composition and structure at the macro- and micro- levels. Materials and methods. We investigated reference well sections in the Imilor deposit to elucidate the interaction of the rocks with sandy-clay landslide pulp, their volumetric weight, ductility or brittleness, caused by the presence or absence of a continuous mineral frame. Results. According to core and well logging data, nine regional packs were distinguished in the BF stratotype. The maximal depth of the natural hydraulic fracturing of the rocks is explained by their high bulk density. The lateral movement of the main slump mass is found to have occured on the stratigraphic level of the first and second BF packs, since these layers possessed zero-buoyancy with regard to the injected pulp under their approximate equality in terms of bulk density. The traces of such active movements were revealed in rock samples from the walls of horizontal cracks in the form of clay intrusions having a thickness of about 0.1 mm and strict orientation of all micro-crystals along the walls and the flow. It is shown that inclusions of the rocks under investigation (bazhenits) in BF are generally characterized by their initial stratigraphic sequence, which is confirmed by the sequential disintegration of proto-bazhenit plates during the process of BF up-floating on a growing sedimentation slope. During the disintegration of the lithified and non-lithified layers of radiolarits, the former crumbled due to alternating loads, while the latter - mobile radiolarites - were represented by the hydraulic fracturing liquid, along with quicksand. Conclusion. A detailed petrographic study of core samples from intact deposits of the Bazhenov and George Formations and their anomalous sections have allowed their layer-by-layer comparison to be confirmed the landslide hypothesis and to be derived the information on the degree of lithification of the BF strata during the formation of its anomalous sections.

Empowerment of Farming Communities through the Utilization of Waste Rice Husk as Briquettes Based Home Industry [Pemberdayaan Masyarakat Tani melalui Pemanfaatan Limbah Sekam Padi sebagai Industri Rumahan Berbasis Briket]

This article proposes to explain how the use of rice husk waste as home industry based briquettes. The making of briquettes from rice husk consists of two ways, specifically with the help of a heater and without a heater. To optimize its manufacture and not require much energy, briquettes from rice husk are quite made without using tools in the process of making briquettes, usually preceded by carbonation. The high element content of rice husk that does rice husk has enormous potential if it is processed into briquettes. Some of the elements contained in rice husks are carbon, silica hydrogen, protein, fat, with very low water content and ash content, a relatively high bulk density of 125 kg / m3 and a high heating value of 1,300 kkal. In addition to the abundant rice husk, the manufacturing process is easy and practical so that it has the potential to be developed in the form of a home industry

Synthesis and characterization of low density porous nickel zinc ferrites

Ni–Zn ferrite has important applications in the field of soft magnetic materials due to its excellent magnetic properties, but its high bulk density hinders its promotion.

Scrap processing - a look into the future

Saturation of depreciation scrap by non-ferrous metals and different nonmetallic materials complicates its utilization for steel smelting, particularly a quality one. For possible avoiding receipt of nonferrous metals into steel melt it is necessary to provide more careful scrap segregation by application of state-of-the-art scrap processing equipment.Main requirement to the steel scrap processing equipment formulated. It must provide uniformity of burden materials fraction content and separation of extraneousmaterials and nonferrous metals.Existing methods of scrap preparation, including different methods of crushing, packaging, separation and other considered. It was shown, that shredder aggregates are most perspective equipment for scrap refining from harmful impurities and its preparation to smelting. Shredder processing of scrap provides the smelting facilities by homogeneous burden of high bulk density.The presented material has a discussion character, aiming at attracting attention of specialists to the problem of scrap processing industry development.

Conceptual design of the mobile granulation line for production fertilizers from digestates and ash mixtures

Paper presents a concept of the mobile line for the production of granulated fertilizer from digestates and ash mixtures. The main assumption of the designed line is its mobility which allows line work in the place of production of digestate. The premise for developing such model of line was the fact that the transport of highly hydrated digestate, as well as its dried form, is not advisable for economic reasons. More advantageous solution is to collect the digestate at the place of its production and it is processed into a fertilizer. Loose components, characterized by high bulk density, can be delivered to the place of production and the same means of transport can be used to transport the produced fertilizer to warehouse. This production model allows to process the digestate produced in several biogas plants, using one production line and reducing the cost of production. of fertilizer granules and the mobile line is transported to the next post-fermentation production point. Based on an analysis of the raw material characteristics and preliminary research on the raw materials mixture granulation process it was assumed that the stage of 3 hrs mixture stabilization time is required in the line.