REVIEW: AN EFFORTS TO INCREASE THE SOLUBILITY AND DISSOLUTION OF ACTIVE PHARMACEUTICAL INGREDIENTS

The most significant aspect of a drug's physicochemical nature is its solubility. If the medicine is in a dissolved form, it can dissolve and enter the membrane, resulting in a therapeutic effect. The pharmacokinetic phase of the drug in the body, which includes absorption, distribution, metabolism, and excretion, will be correlated with solubility. Some medications, however, have a low solubility. To obtain a therapeutic impact, an effort must be made to increase the drug's solubility. Based on the literature research, the goal of this paper is to explain approaches that can be utilized to improve solubility. In general, physical, chemical, and micelle formation efforts can all be used it to enhance solubility. Particle size reduction, crystal shape modification, and the utilization of matrices in the disperse phase are examples of physical alterations. pH adjustment, buffering, salt formation, complexation, and derivatization all are examples of chemical alterations. The employment of supercritical processes in solutions and also excipients such as surfactants, cosolvents, stabilizing solutions, and others are examples of how micelle formation can be modified.

Analysis of Hull Shape Impact on Energy Consumption in an Electric Port Tugboat

The trend to replace internal combustion engines with electric zero-emission drives, visible in the automotive industry, also exists in the shipbuilding industry. In contrary to land vehicles, the requirements for the electric propulsion system of tugs are much greater, which combined with the limited space and energy on board, makes any amount of energy valuable. Strategic changes in the policy of many countries, such as the “Fit for 55” package, introduce plans to significantly reduce CO2 emissions, which favors the development of alternative drives and their introduction to new areas of operation. This article presents that it is possible to reduce the amount of energy an electric tug spends for movement by applying the Particle Swarm Optimization method to modify the shape of its hull. A statistical analysis of public data was performed to determine the speed profiles of actual port tugs. The Van Oortmerssen method was used to determine the hull resistances of the proposed tug and the impact of the hull shape modification sets on reducing these resistances. Based on the six obtained speed profiles, it was determined that one of the tested variants of modifications made it possible to reduce energy consumption on average by 2.12%, to even 3.87% for one of the profiles, and that some modifications increase energy consumption by even 6.59%.

Driving Mechanisms of Double-Nosed Low-Level Jets during MATERHORN Experiment

In the realm of boundary-layer flows in complex terrain, low-level jets (LLJs) have received considerable attention, although little literature is available for double-nosed LLJs that remain not well understood. To this end, we use the MATERHORN dataset to demonstrate that double-nosed LLJs developing within the planetary boundary layer (PBL) are common during stable nocturnal conditions and present two possible mechanisms responsible for their formation. It is observed that the onset of a double-nosed LLJ is associated with a temporary shape modification of an already-established LLJ. The characteristics of these double-nosed LLJs are described using a refined version of identification criteria proposed in the literature, and their formation is classified in terms of two driving mechanisms. The wind-driven mechanism encompasses cases where the two noses are associated with different air masses flowing one on top of the other. The wave-driven mechanism involves the vertical momentum transport by an inertial-gravity wave to generate the second nose. The wave-driven mechanism is corroborated by the analysis of nocturnal double-nosed LLJs, where inertial-gravity waves are generated close to the ground by a sudden flow perturbation.

Effect of Shape Modification on I Girder and Box Girder Prestressed Concrete to Stiffness and Displacement

Prestressed concrete has been widely used in structural buildings, especially for big span length purposes. The prestressed concrete dimension cross sections normally are fixed, provided by the factory based on their experience for every span length. However, this size aspect can be developed to make better improvement. In this study, I and box girder shapes were modified with the same total cross-sectional area. Three types of modification have been made for each girder shape by giving the space on the middle for I girder and changing form from trapezoidal to rectangular section for box girder. The number of steel tendons for this research was made typically and same so that the stress and displacement can be compared fairly. Manual calculation was performed for all samples and was completed under three circumstances namely initial condition, loading condition, and final condition. Also, the manual calculation is according to Indonesian provisions, which are SNI 2833-2016 for the earthquake load and SNI 1725-2016 for normal loading on bridges. From the result, it is known that one shape for each girder shape has met the criteria for the smallest stress and displacement.

Construction of C1 Rational Bi-Quartic Spline With Positivity-Preserving Interpolation: Numerical Results and Analysis

From the observed datasets, we should be able to produce curve surfaces that have the same characteristics as the original datasets. For instance, if the given data are positive, then the resulting curve or surface must be positive on entire given intervals, i.e., everywhere. In this study, a new partial blended rational bi-quartic spline with C1 continuity is constructed through the partially blended scheme. This rational spline is defined on four corners of the rectangular meshes. The sufficient condition for the positivity of rational bi-quartic spline is derived on four boundary curve networks. There are eight free parameters that can be used for shape modification. The first-order partial derivatives are estimated by using numerical techniques. We also show that the proposed scheme is local quadratic reproducing such that it can exactly reproduce the quadratic surface. We test the proposed scheme to interpolate various types of positive surface data. Based on statistical indicators such as the root mean square error (RMSE) and coefficient of determination (R2), we found that the proposed scheme is on par with some established schemes. In fact, it requires less CPU times (in seconds) to generate the interpolating surface on rectangular meshes. Furthermore, by combining the statistical indicators’ result and graphically visualizing the test functions, the proposed method has the capability to reconstruct very comparable smoothing interpolating positive surfaces compared to some existing schemes. This finding is significant in producing a better interpolating surface for computer graphics applications since the proposed scheme has a smaller error compared with existing schemes.