Technologies Involved in the Demulsification of Crude Oil

Due to the use of enhanced recovery processes that necessitate the use of a considerable amount of water, mature petroleum reservoirs generate crude oil with huge amounts of water. The majority of this water gets emulsified into crude oil during production, increasing viscosity and making flow more difficult, resulting in production, transportation, and refining operational challenges that have an influence on corporate productivity. Natural surfactants with a strong potential to create stable emulsions are naturally mixed with crude oils. Because crudes with a high amount of stable emulsion have a lower value, the stable emulsion must be adequately processed to meet industrial requirements. As a result, basic research on natural surfactants that contribute to emulsion stability is examined in order to effectively separate emulsions into oil and water. This would need a review of various emulsification methods as well as the proper formulation for effective demulsification. The petroleum industry recognizes the importance of an efficient demulsification procedure for treating emulsions. Numerous studies on the mechanisms of emulsification and demulsification have been undertaken for decades. To guarantee optimal hydrocarbon output, effective treatment is required. The present paper is to review reported works on the formation of petroleum emulsions, demulsification treatments, and characteristics of fit-for-purpose demulsifiers as well as research trends in emulsion treatment.

Improving the Pharmacological Properties of Ciclopirox for Its Use in Congenital Erythropoietic Porphyria

Congenital erythropoietic porphyria (CEP), also known as Günther’s disease, results from a deficient activity in the fourth enzyme, uroporphyrinogen III synthase (UROIIIS), of the heme pathway. Ciclopirox (CPX) is an off-label drug, topically prescribed as an antifungal. It has been recently shown that it also acts as a pharmacological chaperone in CEP, presenting a specific activity in deleterious mutations in UROIIIS. Despite CPX is active at subtoxic concentrations, acute gastrointestinal (GI) toxicity was found due to the precipitation in the stomach of the active compound and subsequent accumulation in the intestine. To increase its systemic availability, we carried out pharmacokinetic (PK) and pharmacodynamic (PD) studies using alternative formulations for CPX. Such strategy effectively suppressed GI toxicity in WT mice and in a mouse model of the CEP disease (UROIIISP248Q/P248Q). In terms of activity, phosphorylation of CPX yielded good results in CEP cellular models but showed limited activity when administered to the CEP mouse model. These results highlight the need of a proper formulation for pharmacological chaperones used in the treatment of rare diseases.

Assessing the Value of Demand Response in Microgrids

This paper presents a computer application to assist in decisions about sustainability enhancement due to the effect of shifting demand from less favorable periods to periods that are more convenient for the operation of a microgrid. Specifically, assessing how the decisions affect the economic participation of the aggregating agent of the microgrid bidding in an electricity day-ahead market. The aggregating agent must manage microturbines, wind systems, photovoltaic systems, energy storage systems, and loads, facing load uncertainty and further uncertainties due to the use of renewable sources of energy and participation in the day-ahead market. These uncertainties cannot be removed from the decision making, and, therefore, require proper formulation, and the proposed approach customizes a stochastic programming problem for this operation. Case studies show that under these uncertainties and the shifting of demand to convenient periods, there are opportunities to make decisions that lead to significant enhancements of the expected profit. These enhancements are due to better bidding in the day-ahead market and shifting energy consumption in periods of favorable market prices for exporting energy. Through the case studies it is concluded that the proposed approach is useful for the operation of a microgrid.

Biological Seed Treatments

Bacteria and fungi are both used in biological seed treatments. While all have potential uses, some organisms are more widely and successfully used than others. Shelf life is an important consideration. For this reason, organisms that lack cell walls are more difficult to use than ones with long-lasting spores. Bacillus and Trichoderma are both widely effective, have good shelf life, and are frequently used. However, Rhizobiacae lack cell walls, which is a limitation; they are widely used because their symbiosis with legumes facilitates nitrogen fixation which is an important factor that provides economic, agricultural and environmental sustainability. For all organisms, proper formulation is critical for success; this is especially true for Rhizobiacae and other gram-negative bacteria. There are several specialized processes to deliver microbial agents or to enhance their biological activity, such as solid matrix priming and hydroseeding. Biorational chemicals derived from microorganisms are also frequently used. Both living organisms and biorationals provide benefits to plant agriculture. They can control diseases and increase resistance to abiotic stresses such as drought, temperature, salt, and flooding. They also can enhance mineral nutrition and photosynthesis. For these applications, the most effective ones colonize roots internally and provide season-long benefits. These endophytes induce systemic changes in plants’ gene expression and encoding of proteins.

Two Senses of “Probability”

The word “probability” has long been used in (at least) two distinct senses. One sense has to do with a rational agent’s degree of belief, commonly called credence in the philosophical literature. The other sort of probability is thought to be characteristic of a physical system, such as a roulette wheel; these are “in the world” rather than in our heads. This concept is called chance. It would be a mistake to think of these as rivals for the title of the single correct interpretation of probability. Rather, they are both useful concepts, with different roles to play. This chapter is an introduction to these concepts and their relations. It includes a discussion of the proper formulation and justification of a principle that links the two concepts, the Principal Principle. It is argued that neither of these concepts is dispensable. This raises the question of whether there is a notion of probability that can play the role of objective chance and is compatible with deterministic laws of physics.

Morphological and molecular identification of four Purpureocillium isolates and evaluating their efficacy against the sweet potato whitefly, Bemisia tabaci (Genn.) (Hemiptera: Aleyrodidae)

Background Entomopathogenic fungi are widely distributed and well described within the fungal kingdom. This study reports the isolation, characterization, and virulence of 4 Purpureocillium lilacinum isolates against the sweet potato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae). Results Four strains of Purpureocillium lilacinum (XI-1, XI-4, XI-5, and J27) were isolated from soil samples from different localities of China. The morphological studies observed that four strains showed essentially the same morphological characteristics. After 7 days of cultivation, the colonies were purple, round, and bulged. Conidia were single-celled, oval to spindle-shaped, chain-like, and the spore size was about 2.0–2.3 × 3.1–4.0 μm. The genome-based identification results showed that ITS sequences of XI-1 (GenBank accession # MW386433), XI-4 (GenBank accession # MW386434), XI-5 (GenBank accession # MW386435), and J27 (GenBank accession # MW386436) were similar to another P. lilacinum. The newly identified strains of P. lilacinum proved pathogenicity to B. tabaci under laboratory conditions. In addition, the P. lilacinum isolate XI-5 was the most virulent one against different nymphal instars of whitefly having median lethal concentration (LC50) values of 4.99 × 106, 4.82 × 105, and 2.85 × 106 conidia/ml, respectively, 7 days post application. Conclusion The newly isolated strains of P. lilacinum can be developed as a potential biopesticide against the whitefly although extensive field bioassays as well as development of proper formulation are still required.

The d-Dimensional Cosmological Constant and the Holographic Horizons

This article is dedicated to establishing a novel approach to the cosmological constant, in which it is treated as an eigenvalue of a certain Sturm–Liouville problem. The key to this approach lies in the proper formulation of physically relevant boundary conditions. Our suggestion in this regard is to utilize the “holographic boundary condition”, under which the cosmological horizon can only bear a natural (i.e., non-fractional) number of bits of information. Under this framework, we study the general d-dimensional problem and derive the general formula for the discrete spectrum of a positive energy density of vacuum. For the particular case of two dimensions, the resultant problem can be analytically solved in the degenerate hypergeometric functions, so it is possible to define explicitly a self-action potential, which determines the fields of matter in the model. We conclude the article by taking a look at the d-dimensional model of a fractal horizon, where the Bekenstein’s formula for the entropy gets replaced by the Barrow entropy. This gives us a chance to discuss a recently realized problem of possible existence of naked singularities in the D≠3 models.

ÁLCOOL EM GEL PARA ASSEPSIA DAS MÃOS – FORMULAÇÃO ADEQUADA E EFICIÊNCIA GARANTIDA EM MEIO À PANDEMIA DA COVID-19

ALCOHOL GEL FOR ASEPSY OF THE HANDS – PROPER FORMULATION AND GUARANTEED EFFICIENCY AMID THE PANDEMIC OF COVID-19. The use of hand antiseptics became widespread as a routine in the fight against COVID-19. In the market, the availability and purchase of substandard antiseptics create a permanent concern with safety, even after a pandemic. Therefore, the development of easy-to-deploy analytical methods for the quality control of alcohol-based hand antiseptics is needed. In this work, to determine the ethanol content in alcohol gel the use of refractometry and alcohol oxidation method by dichromate accompanied by UV-Vis spectroscopy were applied. The results indicated that 19 brands (out of the 70 evaluated) (27.1%) had levels of ethyl alcohol below the recommended level (68.25%), therefore, they are ineffective for hand asepsis. For the quality control of hand antiseptics, refractometry and the oxidation-reduction reaction are complementary analytical methodologies. As a quick, inexpensive screening method, refractometry provides a more suitable technique. However, the interference of emollients may affect the accuracy of the ethanol content determination. Therefore, applying the ethanol oxidation method coupled with electronic spectroscopy offers a simple and broadly accessible method to confirm the ethanol content in alcohol-based hand antiseptics. In addition to developing quality control protocols, is also described the 3.5-ton production of alcohol gel at the Federal University of Bahia.

Comments on Gideon Rosen’s “What is Normative Necessity?”

Gideon Rosen supports the central theses of “Varieties of Necessity” (VN) concerning the distinction between metaphysical and normative necessity and the proper formulation of moral supervenience; and he takes the defense of these theses much further than I did in my own paper and makes the case for them especially vivid and compelling. I was especially impressed by his attempt to find out what might lie ...