scholarly journals Dysbiosis of vaginal microbiota associated with persistent high-risk human papilloma virus infection

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Ling Mei ◽  
Tao Wang ◽  
Yueyue Chen ◽  
Dongmei Wei ◽  
Yueting Zhang ◽  
...  
Keyword(s):  
High Risk ◽  
Human Papilloma Virus ◽  
Relative Abundance ◽  
Human Papilloma Virus Infection ◽  
Hpv Infection ◽  
Vaginal Microbiota ◽  
Differential Analysis ◽  
Papilloma Virus ◽  
Linear Discriminant ◽  
Potential Factors

Abstract Background The status of vaginal microbiota in persistent high-risk human papilloma virus (HR-HPV) infection is unclear. The present work aimed to identify the vaginal microbiota of persistent HPV infection and explore the possible underlying microbiota factors. Methods A total of 100 women were recruited in this study, of which 28 presented HR-HPV persistent infection (P group), 30 showed clearance of any subtype of HR-HPV (C group), and 42 had no history of any HR-HPV infection (NC group). The vaginal microbiota and the community structure of the three groups were compared based on the 16S rRNA sequencing of the V3–V4 region. The microbiota diversity and differential analysis were carried out to detect the potential factors associated with HR-HPV infection. Results P and C groups showed an increase of Firmicutes and Actinobacteriota but a decrease in Proteobacteria compared to the NC group. The Chao1 index indicated that the microbial richness of the NC group was greater than C group (P < 0.05).The principal co-ordinate analysis(PCoA) revealed differences between the NC and P/C groups.The linear discriminant analysis effect size (LEfSe) method indicated that Proteobacteria phylum was significantly different in the mean relative abundance in the NC group,but the P and C groups did not show such indicative taxa. The Wilcox rank-sum test indicated that the Bifidobacterium (P = 0.002) and Lactobacillus (P = 0.005) of the C group were in a high mean relative abundance compared to the NC group. Conclusions The persistent HR-HPV infection is associated with dysbiosis of the vaginal microbiota. Microbiome regulation with Bifidobacteria and Lactobacillus may affect the clearance of HPV.

scholarly journals Awareness and Knowledge about Human Papilloma Virus Infection among Students at Secondary Occupational Health School in China

2021 ◽  
Vol 18 (12) ◽  
pp. 6321
Author(s):  
Xin Wang ◽  
Taifeng Du ◽  
Xiaoling Shi ◽  
Kusheng Wu
Keyword(s):  
Occupational Health ◽  
Human Papilloma Virus ◽  
Healthcare Providers ◽  
Human Papilloma Virus Infection ◽  
First Grade ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Causal Link ◽  
Cross Sectional ◽  
Papilloma Virus

Cervical cancer (CC) is one of the most common causes of cancer-related deaths worldwide. CC is mainly caused by human papilloma virus (HPV), which can be prevented by vaccination. We conducted a cross-sectional study in secondary occupational health school (SOHS) through a questionnaire aimed to assess the awareness and knowledge regarding HPV infection of students. A total of 2248 students participated in the survey, 45.3% of them had heard about CC, while only 21.9% of them had heard about HPV; and 74.2% had no idea of the causal link between HPV infection and CC. Most participants displayed poor awareness and knowledge about HPV infection. The results suggested that age, grade, major, academic performance, etc. were correlated with higher awareness of CC, HPV and HPV infection (p < 0.05). In multivariable logistic analysis, third-grade students had the most increased awareness of CC (OR = 17.13, 95%CI: [8.11, 36.15]), HPV (OR = 6.59, 95%CI: [4.16, 10.43]) and HPV vaccine (OR = 2.78, 95%CI: [1.78, 4.32]) when compared to first-grade. Awareness and knowledge regarding HPV infection were insufficient among students in SOHS. As the future healthcare providers, these results highlight the need to supplement targeted education to improve their awareness and knowledge of HPV and vaccination.

scholarly journals High-risk human papilloma virus infection decreases the frequency of dendritic Langerhans' cells in the human female genital tract

Immunology ◽  
2006 ◽  
Vol 117 (2) ◽  
pp. 220-228 ◽  
Author(s):  
Rafael Jimenez-Flores ◽  
Rene Mendez-Cruz ◽  
Jorge Ojeda-Ortiz ◽  
Rebeca Munoz-Molina ◽  
Oscar Balderas-Carrillo ◽  
...  
Keyword(s):  
High Risk ◽  
Virus Infection ◽  
Human Papilloma Virus ◽  
Genital Tract ◽  
Langerhans Cells ◽  
Female Genital Tract ◽  
Human Papilloma Virus Infection ◽  
Human Female ◽  
Papilloma Virus ◽  
Female Genital

scholarly journals 1641. A Comparison of Human Papilloma Virus Infection Prevalence Trends Pre- and Post-HPV Vaccine Implementation

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S599-S599
Author(s):  
Patrick Ovie. Fueta ◽  
Onyema Greg Chido-Amajuoyi
Keyword(s):  
United States ◽  
Human Papilloma Virus ◽  
Hpv Vaccine ◽  
Human Papilloma Virus Infection ◽  
The United States ◽  
Hpv Infection ◽  
Infection Prevalence ◽  
Transmitted Infection ◽  
Papilloma Virus ◽  
The Impact

Abstract Background Human papilloma virus (HPV) is the most common sexually transmitted infection in the United States, with an annual incidence rate of approximately 14 million people. The HPV vaccine has been demonstrated to be highly effective in the prevention of HPV infection and HPV-associated diseases. This study aims to evaluate the impact of HPV vaccine on the prevalence of HPV infection in the United States and evaluate the trends of disease prevalence pre- and post-HPV vaccine implementation. Methods We conducted a secondary data analysis of the National Health and Education Survey (NHANES) for trends in HPV infection from 2003 to 2016. The analysis was grouped into a pre-HPV vaccine implementation (2003–2006) cohort including 4064 females, aged 18–59 years; and a post-HPV vaccine implementation (2007–2016) cohort which included 10718 females, aged 18–59 years. Further analysis of HPV infection prevalence, pre- and post-HPV vaccine implementation, stratified by sociodemographic characteristics were conducted. Results The prevalence of HPV infection prior to HPV vaccine implementation was 43.98% (95 CI 42.71%–46.58%) compared with 40.55% (95 C.I 40.55%–40.56%) in the post-HPV vaccine implementation era. Among females with HPV infections in the post-HPV vaccine implementation cohort 82.6 (95% CI 80.41%–83.42%) were unvaccinated. In both cohorts, black females had a significantly higher prevalence of HPV with a prevalence rate of 18.56% (95% CI 18.23%–20.56%) in the pre-HPV vaccine implementation cohort, and 15.61% (95% CI 14.82 – 19.4%) in the post-HPV vaccine implementation cohort. Females with less than high school education had a higher prevalence of HPV in the pre and post- HPV vaccine implementation cohorts with prevalence rates of 25.77% (95% CI 23.44%–28.72%) and 24.96% (95% CI 23.41%–25.67%), respectively. Conclusion The results suggest that HPV infection prevalence has declined since the implementation of HPV vaccine to US national immunization program. Our findings highlight disparities in HPV infection prevalence by race and educational status, and these patterns are in keeping with HPV-associated disease such as warts and HPV-associated cancers. Disclosures All authors: No reported disclosures.

scholarly journals RPS19 and TYMS SNPs and Prevalent High Risk Human Papilloma Virus Infection in Nigerian Women

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66930 ◽  
Author(s):  
Ayo Famooto ◽  
Maryam Almujtaba ◽  
Eileen Dareng ◽  
Sally Akarolo-Anthony ◽  
Celestine Ogbonna ◽  
...  
Keyword(s):  
High Risk ◽  
Virus Infection ◽  
Human Papilloma Virus ◽  
Human Papilloma Virus Infection ◽  
Papilloma Virus ◽  
Nigerian Women

scholarly journals Knowledge, Attitude and Practice of Main Stakeholders towards Human Papilloma Virus Infection and Vaccination in Mombasa and Tana-River Counties in Kenya: A Qualitative Study

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1099
Author(s):  
Diana Wangeshi Njuguna ◽  
Nour Mahrouseh ◽  
Osarugue Victory Isowamwen ◽  
Orsolya Varga
Keyword(s):  
Human Papilloma Virus ◽  
Hpv Vaccine ◽  
Health Workers ◽  
Hpv Vaccination ◽  
Significant Proportion ◽  
Human Papilloma Virus Infection ◽  
Hpv Infection ◽  
Structured Interviews ◽  
Papilloma Virus ◽  
Tana River

Following a successful Human Papilloma Virus (HPV) vaccination pilot in 2013–2015 in Kitui county, Kenya introduced the HPV vaccine in October 2019 with a goal to immunize approximately 800,000 girls annually against HPV. Our study assessed the knowledge, attitudes, and practice of affected groups towards HPV infection and vaccination in two counties of Kenya. Semi-structured interviews from children aged between nine and thirteen years and key informants comprising of parents, head teachers, community leaders and health workers involved in HPV vaccination in health facilities from Mombasa and Tana-River counties were conducted. Content was analyzed thematically and coded for emerging themes using the QRS Nvivo 12 Plus software package. From our findings, a significant proportion of participants, especially children, have limited knowledge of the subject. Vaccination of boys was opposed by most participants. Parents and the community members are not in favor of HPV vaccination, as compared to the other groups. A similar pattern of inadequate knowledge and strongly opposed attitudes was observed in Tana-River and Mombasa. Active community involvement in primary prevention strategies may promote the uptake of the vaccine which can be achieved by robust awareness, modifying the negative beliefs about HPV vaccine and encouraging the perceptibility of HPV vaccination.

scholarly journals Distinction Between Vaginal and Cervical Microbiota in High-risk Human Papilloma Virus Infected Women in China

2020 ◽  
Author(s):  
Zhan Zhang ◽  
Ting Li ◽  
Dai Zhang ◽  
Xiaonan Zong ◽  
Huihui Bai ◽  
...  
Keyword(s):  
High Risk ◽  
Human Papilloma Virus ◽  
Chinese Women ◽  
Variable Region ◽  
Vaginal Microbiota ◽  
Rrna Gene ◽  
Papilloma Virus ◽  
Next Generation Sequencing Technology ◽  
History Of ◽  
High Risk Hpv

Abstract Background: High-risk human papilloma virus (hrHPV) is regarded as the main causal factor of cervical precancer and cancer when persistent infection is left untreated. Previous studies have declared that HPV is associated with microecological environment of lower genital tract but haven’t discriminate vaginal microbiota from that of cervix. Objective: To analyze the distinction between vaginal and cervical microbiota in high-risk HPV(+) Chinese women. Methods: One hundred participants were recruited including 20 healthy women with HPV (-), 32 with other hrHPV (+), 38 subjects with HPV16/18 (+) and 10 with cervical carcinoma, demographics of whom were collected and analyzed. Vaginal and cervical microbiota were separately tested through next-generation sequencing technology (NGS) targeting the variable region (V3-V4) of bacterial ribosome 16S rRNA gene. Results: 1. Analysis of demographics demonstrated that hrHPV infected women tend to be accustomed to vaginal douching (p =0.001), show more frequent usage of sanitary pads (p =0.007), have more sex partners (p =0.047), be more sexually active (p =0.025), have more diverse ways of contraception (p =0.001) and history of vaginitis (p =0.002). 2. NGS identified microbial diversity of cervical microbiota was much higher than that of vagina with significantly increased Proteobacteria and decreased Lactobacillus. Variation of cervical microbiota of hrHPV(+) subjects partly similar to vaginal microbiota but had its unique features. Sphingomonas of α-Proteobacteria, almost invisible in the vagina, was more frequent at normal cervix whereas decreased remarkably at hrHPV(+) cervix. Reversely, γ-Proteobacteria showed a significant positive correlation with HPV16/18 and cervical cancer. BV related anaerobes like Gardnerella, Prevotella, Atopobium and Sneathia showed similar changes in both vaginal and cervical microbiota of hrHPV(+) women and did not exhibit cervical specificity. Conclusions: Cervical microbiota has its uniqueness from that of vagina in bacterial communities presenting a higher proportion of Proteobacteria, of which Sphingomonas is potentially predictive of a health guardian of hrHPV while Pseudomonas the opposite.

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