834 ENDOSCOPIC VACUUM THERAPY IN THE MANAGEMENT OF OESOPHAGEAL PERFORATIONS AND POST-OPERATIVE LEAKS

Oesophageal perforations and post-oesophagectomy anastomotic leaks are associated with high morbidity and mortality. Endoscopic vacuum therapy (EVT) is a novel treatment strategy with the potential to promote healing and ameliorate sepsis. Few instances of the use of EVT have been reported in the UK, wioth only two cases published outside our centre representing a limited aetiological and demographic spectrum. Methods From May 2019 to November 2020 8 patients aged 27–85 years underwent EVT for disparate oesophageal wall defects. Data regarding technical success and feasibility were analysed. Video recordings of procedures were undertaken with patient consent. Results Complete defect resolution was achieved in cases (87%), requiring median of 13 days of treatment (range 6–23), and necessitating 3 replacement procedures (range 1–4). Significant improvement in C-reactive protein was achieved in all patients undergoing treatment (P = 0.015). Over an average follow up of 360 days, no severe complications resulted directly from sponge placement, however 2 individuals (25%) developed oesophageal stricture necessitating endoscopic balloon dilatation, and one died whilst undergoing treatment. Conclusion Here we provide a video demonstration of the application of EVT in patients with oesophageal perforation or post-operative leak. Our data demonstrate this approach to be a safe, valuable tool for the management of a spectrum of oesophageal wall defects, with the potential to reduce associated morbidity and mortality in selected patients. Video Video of safe application of EVT. https://www.dropbox.com/s/rgypt6o1z93iui5/EVT.mp4?dl=0.

Diagnosis and management of cold urticaria in cryoablation of atrial fibrillation: a case report

Background Cold-induced urticaria is triggered by exposure to local or environmental cold and manifests as localized or systemic pruritic papules, sometimes accompanied by angio-oedema and anaphylaxis representing a life-threatening condition. Therapy options of atrial fibrillation (AF) include catheter ablation with different energy sources, of which cryoenergy may be superior to other energy sources regarding safety and efficacy. Case summary We report the case of a 60-year-old man suffering from symptomatic paroxysmal AF. The patient had a history of cold-induced urticaria without occurrence of systemic reactions to date. After successful pulmonary vein isolation (PVI) using cryoenergy, post-interventional oesophagogastroduodenoscopy and endosonography revealed newly occurred oedema in the middle oesophagus with inclusion of all oesophageal wall layers. Due to missing peri-atrial lesions, activation of cold urticaria during cryoablation rather than procedure-associated alterations was diagnosed. The patient reported no systemic or gastrointestinal symptoms after PVI. Discussion We could demonstrate that cold urticaria can manifest as oesophageal angio-oedema in AF patients undergoing cryoablation. Therefore, these patients should be carefully considered for an alternative energy source for PVI or premedication with antihistamines when using cryoenergy.

An unusal case of hematemesis in a patient with type 1 diabetes mellitus

Diabetes is a metabolic disorder characterised by hyperglycemia, with disturbances of carbohydrate, fat and protein metabolism. Here is the report of an unusual case of hematemesis in a patient with type 1 diabetes mellitus.Hematemesis refers to vomiting of blood and can be explained as the backward flow of blood through the upper gastrointestinal tract.Hematemesis is an extremely serious condition that should be treated at the earliest.Diabetics are prone to opportunistic infections by Candida, which can range from oral candidiasis to oesophageal candidiasis. Oesophageal candidiasis causes erosion of the stomach and oesophageal wall which can lead to gastritis and hematemesis.

Sentinel Bleeding as a Sign of Gastroaortic Fistula Formation after Oesophageal Surgery

Gastroaortic fistula formation is a very rare complication following oesophageal resection and, in most cases, leads to sudden death. We report the case of a 65-year-old male with an adenocarcinoma of the oesophagus who underwent neoadjuvant chemoradiation followed by a minimally invasive transthoracic oesophagectomy with gastric tube reconstruction and intrathoracic anastomosis. After an uneventful postoperative course and hospital discharge, the patient reported blood regurgitation on postoperative day 23. Endoscopy revealed an adherent blood clot on the oesophageal wall, which after dislocation caused exsanguination. Autopsy determined the cause of death being massive haemorrhage due to a gastroaortic fistula. The sudden onset of haemorrhage makes this condition particularly difficult to treat. Recognition of warning signs such as thoracic or epigastric pain, regurgitation of blood, or the passing of bloody stools or melena is crucial in the early detection of fistula and may improve patient outcome.

Intraductal papillary mucinous neoplasm of the oesophagus: an unusual case of dysphagia

We report the case of a 58-year-old woman presenting with dysphagia secondary to an intraductal papillary mucinous neoplasm arising from a heterotopic pancreas in the oesophageal wall. This was successfully treated with a laparoscopic/thoracoscopic ivor Lewis oesophagectomy. Dysphagia is the most common symptom of oesophageal tumours regardless of aetiology of the tumour and can be treated successfully with surgical resection. Through an extensive search of the literature, we found that a heterotopic pancreas in the oesophagus is extremely rare with only ten cases being reported. We describe what we believe to be the first case of a heterotopic pancreas in the oesophagus transforming into an intraductal papillary mucinous neoplasm.