A genetic history of migration, diversification, and admixture in Asia

L.L. Cavalli-Sforza spearheaded early efforts to study the genetic history of humans, recognizing the importance of sampling diverse populations worldwide. He supported research on human evolutionary genetics in Asia, with research on human dispersal into Asia and genetic distances between present-day East Asians in the late 20th century. Since then, great strides have been made in understanding the genetic history of humans in Asia, through large-scale genomic sequencing of present-day humans and targeted sequencing of DNA from ancient humans. In this review, I survey the genetic prehistory of humans in Asia, based on research using sequence data from humans who lived in Asia as early as 45,000 years ago. Genetic studies comparing present-day Australasians and Asians show that they likely derived from a single dispersal out of Africa, rapidly differentiating into three main lineages: one that persists partially in South Asia, one that is primarily found today in Australasia, and one that is widely represented across Siberia, East Asia, and Southeast Asia. Studies of ancient DNA from human remains in Asia dating from as far back as 45,000 years has greatly increased our understanding of the population dynamics leading to the current Asian populations. Based on "Jin L, Underhill PA, Doctor V, Davis RW, Shen P, Cavalli-Sforza LL, Oefner PJ. Distribution of haplotypes from a chromosome 21 region distinguishes multiple prehistoric human migrations. Proc Natl Acad Sci U S A. 1999;96(7):3796-3800”.

Female craniometrics support the ‘two-layer model’ of human dispersal in Eastern Eurasia

This study reports a cranio-morphometric analysis of female human remains from seven archaeological sites in China, Vietnam and Taiwan that date between 16,000 and 5300 BP. The aim of the analysis is to test the “two-layer” model of human dispersal in eastern Eurasia, using previously unanalysed female remains to balance the large sample of previously-analysed males. The resulting craniometric data indicate that the examined specimens all belong to the “first layer” of dispersal, and share a common ancestor with recent Australian and Papuan populations, and the ancient Jomon people of Japan. The analysed specimens pre-date the expansion of agricultural populations of East/Northeast Asian origin—that is, the “second layer” of human dispersal proposed by the model. As a result of this study, the two-layer model, which has hitherto rested on evidence only from male skeletons, is now strongly supported by female-derived data. Further comparisons reveal that the people of the first layer were closer in terms of their facial morphology to modern Africans and Sri Lankan Veddah than to modern Asians and Europeans, suggesting that the Late Pleistocene through Middle Holocene hunter-gatherers examined in this study were direct descendants of the anatomically modern humans who first migrated out of Africa through southern Eurasia.

Modern Siberian dog ancestry was shaped by several thousand years of Eurasian-wide trade and human dispersal

Dogs have been essential to life in the Siberian Arctic for over 9,500 y, and this tight link between people and dogs continues in Siberian communities. Although Arctic Siberian groups such as the Nenets received limited gene flow from neighboring groups, archaeological evidence suggests that metallurgy and new subsistence strategies emerged in Northwest Siberia around 2,000 y ago. It is unclear if the Siberian Arctic dog population was as continuous as the people of the region or if instead admixture occurred, possibly in relation to the influx of material culture from other parts of Eurasia. To address this question, we sequenced and analyzed the genomes of 20 ancient and historical Siberian and Eurasian Steppe dogs. Our analyses indicate that while Siberian dogs were genetically homogenous between 9,500 to 7,000 y ago, later introduction of dogs from the Eurasian Steppe and Europe led to substantial admixture. This is clearly the case in the Iamal-Nenets region (Northwestern Siberia) where dogs from the Iron Age period (∼2,000 y ago) possess substantially less ancestry related to European and Steppe dogs than dogs from the medieval period (∼1,000 y ago). Combined with findings of nonlocal materials recovered from these archaeological sites, including glass beads and metal items, these results indicate that Northwest Siberian communities were connected to a larger trade network through which they acquired genetically distinctive dogs from other regions. These exchanges were part of a series of major societal changes, including the rise of large-scale reindeer pastoralism ∼800 y ago.

Glacial kettles as archives of early human settlement along the Northern Rocky Mountain Front

The Northern Rocky Mountain Front (hereafter Northern Front) is a prominent geographic feature in archaeological models of human dispersal in the terminal Pleistocene and Early Holocene of North America. Testing those models has been arduous because of local geomorphological factors that tend to obliterate or otherwise limit access to archaeological finds of relevant age. In this paper, we present well-stratified archaeological and environmental records dating back to 14,000–13,000 cal yr BP from the site of Billy Big Spring (Blackfeet Indian Reservation, Montana), located on a glacial kettle, a type of landform that has been largely ignored by regional archaeological research to date. Findings from Billy Big Spring show the continuous use of the Northern Front foothills throughout the major climatic and environmental disturbances of the Early Holocene, and possibly the terminal Pleistocene as well. As such, Billy Big Spring contributes to refining several archaeological models of early settlement of the Northern Front, particularly those that posit differential use of foothills versus plains settings during the midst of the Holocene Thermal Maximum. The record at Billy Big Spring also suggests that kettles, regardless of physiographic setting, provide a yet unsuspected and unsampled potential for preserving high-quality and easily accessible early archaeological and paleoenvironmental records.

Hydroclimate changes in eastern Africa over the past 200,000 years may have influenced early human dispersal

Reconstructions of climatic and environmental conditions can contribute to current debates about the factors that influenced early human dispersal within and beyond Africa. Here we analyse a 200,000-year multi-proxy paleoclimate record from Chew Bahir, a tectonic lake basin in the southern Ethiopian rift. Our record reveals two modes of climate change, both associated temporally and regionally with a specific type of human behavior. The first is a long-term trend towards greater aridity between 200,000 and 60,000 years ago, modulated by precession-driven wet-dry cycles. Here, more favorable wetter environmental conditions may have facilitated long-range human expansion into new territory, while less favorable dry periods may have led to spatial constriction and isolation of local human populations. The second mode of climate change observed since 60,000 years ago mimics millennial to centennial-scale Dansgaard-Oeschger cycles and Heinrich events. We hypothesize that human populations may have responded to these shorter climate fluctuations with local dispersal between montane and lowland habitats.

Climate Variability reconstructed from La Cueva Chica speleothems for the last 13 ka BP: implications for Megafauna in Southern Patagonia, Chile.

<p>Investigating palaeoclimate records is of major importance for evaluating the impact of past forcing factors on the evolution of ecosystems, megafauna and human dispersal, especially in Southern Patagonia where few records are available. We report on a 40 cm long flowstone core S6, and fragments of flowstone and a stalagmite from Cueva Chica. The samples were radiometrically dated (U-Th & <sup>14</sup>C) to construct age-depth models for the proxy profiles (δ<sup>13</sup>C, δ<sup>18</sup>O, and chemical composition). The speleothem proxy data are further informed by both petrographic analysis of the flowstone, and monitoring data. The main objectives of this work are to: i) reconstruct past climate variations using geochemical analyses conducted on the speleothems, and ii) assess the palaeoclimatic context of megafauna extinction in the area. The flowstone core S6 grew discontinuously from ~13 ka to ~1 ka with several possible hiatuses at ~10 ka BP, from 5.7 to 3.0 ka BP, and 2.5 to 1.8 ka BP (interpolated ages). Sample S8 grew from 6.8 to 5.8 ka BP and after 1.2 ka BP. Stable isotopes analyzed at sub-centennial resolution show a 3‰ range for δ<sup>18</sup>O, and more than 14‰ for δ<sup>13</sup>C, and the isotope ratios covary along the entire record. These changes are likely caused by kinetic fractionation and prior calcite precipitation (PCP), controlled mostly by changes in moisture availability. The sensitivity of the proxies to hydrological changes and PCP is further tested with indicators using μXRF element data. The multiproxy record from Cueva Chica suggests a wet phase from ~13 to 9 ka BP, likely related to strong westerlies in the Southern Hemisphere, preceded by a short dry/cold spell at ~13 ka BP. This early Holocene wet phase was followed by a colder/drier period from 8.5 to 5.8 ka BP, likely related to weaker westerlies, especially during the mid-Holocene. High precipitation and strong westerlies prevailed from 3.0 to 2.5 ka BP and in Medieval times. Our paleoclimate record implies that the presence of extensive megafauna, the development of Nothofagus forest and human arrival, all occurred during a climatically favorable wet/warm period ca. 13 to 9 ka BP, after the Antarctic Cold Reversal. However, the deterioration of the vegetation cover at the Cerro Benitez coinciding with high δ<sup>13</sup>C values excursions was initiated after ca. 11 ka BP. Previous studies suggest an extinction of major megafauna species (e.g., Mylodon, Smilodon, Panthera onca mesembrina) during this wet/warm period. Such climate-driven changes likely reduced the open ecosystem environment and may have led to local decline of herbivore populations. Later cooling/drying after ca. 9 ka may have contributed to the disappearance of megafauna and other large mamals (e.g., Hippidion Saldiasi).</p>