The Historic K s Light Curve of the FUor PGIR20dci

We report a historic K s -band light curve spanning over three decades of the FUor PGIR20dci recently discovered by Hillenbrand et al. We find some minor variability of the object prior to the FUor outburst, an initial rather slow rise in brightness, followed in 2019 by a much steeper rise to the maximum.

Time-Frequency Characteristics and the Influence Mechanism of the EMR from Coal with Different Joint Angles

It is vital to understand the electromagnetic radiation’s time-frequency characteristics in the process of coal and rock failure with different joint angles in order to reveal the generation mechanism of the electromagnetic radiation (EMR) and improve the accuracy of EMR early warning. We studied the time-frequency characteristics of EMR signals of coal samples with different joint angles. The study finds that, (1) with the increase of joint angle, the failure time and peak load of samples decrease first and increase later, and the postpeak failure time decreases gradually. The EMR counts’ peak value showed a slow rise, a sharp rise, and a slow rise in the three intervals of α = 0° to 45°, 45° to 60°, and 60° to 90°, respectively. The accumulated EMR counts showed a steady upward trend. The duration of the EMR waveform, the dominant frequency of the EMR, and the peak number of the frequency spectrum of coal samples are on the rise. (2) As the joint angle increases, the samples’ failure mode changes from the stage fracture dominated by tension cracks to the rapid fracture with the coexistence of shear and tension cracks and finally to the burst fracture which produces a large number of fragments. This is also the main reason for the difference of the EMR generation mechanism and the signal of samples with different joint angles. (3) According to the experimental results, we established the modified formulas for calculating the EMR threshold value and deviation of coal and rock with joints under different stress environments and revealed that the longer the EMR waveform duration, the higher the dominant frequency, and the more the number of spectrum peaks, the greater the burst risk of coal and rock.

Water Pores in Planar Lipid Bilayers at Fast and Slow Rise of Transmembrane Voltage

Basic understanding of the barrier properties of biological membranes can be obtained by studying model systems, such as planar lipid bilayers. Here, we study water pores in planar lipid bilayers in the presence of transmembrane voltage. Planar lipid bilayers were exposed to fast and slow linearly increasing voltage and current signals. We measured the capacitance, breakdown voltage, and rupture time of planar lipid bilayers composed of 1-pamitoyl 2-oleoyl phosphatidylcholine (POPC), 1-pamitoyl 2-oleoyl phosphatidylserine (POPS), and a mixture of both lipids in a 1:1 ratio. Based on the measurements, we evaluated the change in the capacitance of the planar lipid bilayer corresponding to water pores, the radius of water pores at membrane rupture, and the fraction of the area of the planar lipid bilayer occupied by water pores.planar lipid bilayer capacitance, which corresponds to water pores, water pore radius at the membrane rupture, and a fraction of the planar lipid bilayer area occupied by water pores. The estimated pore radii determining the rupture of the planar lipid bilayer upon fast build-up of transmembrane voltage are 0.101 nm, 0.110 nm, and 0.106 nm for membranes composed of POPC, POPS, and POPC:POPS, respectively. The fraction of the surface occupied by water pores at the moment of rupture of the planar lipid bilayer The fraction of an area that is occupied by water pores at the moment of planar lipid bilayer rupture is in the range of 0.1–1.8%.

Compound Heterozygous KCNQ1 Mutations Causing Recessive Romano–Ward Syndrome: Functional Characterization by Mutant Co-expression

Next Generation Sequencing has identified many KCNQ1 genetic variants associated with type 1 long QT or Romano-Ward syndrome, most frequently inherited in an autosomal dominant fashion, although recessive forms have been reported. Particularly in the case of missense variants, functional studies of mutants are of aid to establish variant pathogenicity and to understand the mechanistic basis of disease. Two compound heterozygous KCNQ1 mutations (p.A300T and p.P535T) were previously found in a child who suffered sudden death. To provide further insight into the clinical significance and basis for pathogenicity of these variants, different combinations of wildtype, A300T and P535T alleles were co-expressed with the accessory β-subunit minK in HEK293 cells, to analyze colocalization with the plasma membrane and some biophysical phenotypes of homo and heterotetrameric channels using the patch-clamp technique. A300T homotetrameric channels showed left-shifted activation V1/2 as previously observed in Xenopus oocytes, decreased maximum conductance density, slow rise-time300ms, and a characteristic use-dependent response. A300T slow rise-time300ms and use-dependent response behaved as dominant biophysical traits for all allele combinations. The P535T variant significantly decreased maximum conductance density and Kv7.1-minK-plasma membrane colocalization. P535T/A300T heterotetrameric channels showed decreased colocalization with plasma membrane, slow rise-time300ms and the A300T characteristic use-dependent response. While A300T left shifted activation voltage dependence behaved as a recessive trait when co-expressed with WT alleles, it was dominant when co-expressed with P535T alleles.Conclusions: The combination of P535T/A300T channel biophysical properties is compatible with recessive Romano Ward syndrome. Further analysis of other biophysical traits may identify other mechanisms involved in the pathophysiology of this disease.

Where do we go from here? Exploring the future of mixed families between Italy and South Asia

Family labor migration from South Asia to Europe is often framed as proceeding in a predictable pattern of “male first-time migrant, ethnic marriage and spouse reunion.” Migration to Northern Italy is no exception. Primary data from recent ethnographic fieldwork reveal a slow rise in mixed South Asian–Italian couples, which might bring into question the quandaries they face in raising children. This article considers the daily struggles in conjugal and parental relations in mixed-culture households formed by spouses, one of whom is from a South Asian background, and the other is an Italian “native.” Applying intersectional analysis to the life stories and aspirations of such cross-cultural new generations allows for revisiting the commonplace view of South Asia–Europe intimate links.

Epidemiological and Clinical Profile of COVID-19 in Nepali Children: An Initial Experience

Introduction: COVID-19 has spread all around the world with huge toll of human lives and suffering since it evolved in China. Nepal had slow rise in morbidity due to COVID 19 in early days but has been gripped by the pandemic's exponential growth lately. This study was conducted with the aim to describe the clinical and epidemiological features of Nepali children in early phase of the pandemic. Methods: This was an observational study conducted at 11 COVID care centres designated by the Government of Nepal with availability of supervision by paediatricians between January and August 2020 in children under 18 years of age diagnosed with COVID 19. Data was collected based on definitions outlined in data collection resources available at WHO-ISARIC Global COVID-19 clinical resources platform and analysed. Results: One hundred and twenty one children diagnosed with COVID 19 who presented to the designated centres were enrolled. Majority of children (83.4%) were identified as a part of contact tracing, 28.1% had an identified contact to a person with COVID 19 prior to their diagnosis and 20.7% had another household member diagnosed with COVID 19. The mean age of admitted children was 8.8 years (SD 5.6 years) with the largest proportion being adolescents (40.5%). Male (58.7%) children were more commonly affected. There were 15 (12.4%) infants and 8 (6%) of them were under two months of age. Most children (87, 71.9%) were asymptomatic, 21 (22.3%) had mild symptoms and six (4.9%) had moderately severe symptoms. Fever (18.2%) was the most commonly reported symptom. All children were discharged after a median of 14 days of hospitalisation. Conclusions: Nepali children of all ages are affected by COVID 19 and present with asymptomatic or mildly symptomatic infection. Fever and respiratory symptoms are the most commonly reported symptoms. Most children do not develop complications. Continued surveillance in larger population of children as the pandemic unfolds will generate more stringent observations.

Dual-functional ultraviolet photodetector with graphene electrodes on AlGaN/GaN heterostructure

A dual-functional ultraviolet (UV) photodetector with a large UV-to-visible rejection ratio is presented, in which interdigitated finger-type two-dimensional graphene electrodes are introduced to an AlGaN/GaN heterostructure. Two photocurrent generation mechanisms of photovoltaic and photoconductive dominances coexist in the device. The dominance of the mechanisms changes with the induced bias voltage. Below a threshold voltage, the device showed fairly low responsivities but fast response times, as well as a constant photocurrent against the induced bias. However, the opposite characteristics appeared with high bias voltage. Specifically, above the threshold voltage, the device showed high responsivities with additional gain, but slow rise and recovery times. For instance, the responsivity of 10.9 A/W was observed with the gain of 760 at the induced bias voltage of 5 V. This unique multifunctionality enabled by the combination of an AlGaN/GaN heterostructure with graphene electrodes facilitates the development of a single device that can achieve multiple purposes of photodetection.

Reappraising Jewish War Experiences, 1914–18

This chapter talks about the Jewish war experience in the German military and the slow rise of anti-Semitism starting from the end of the World War 1. Although Jewish experiences during World War I cannot be reduced to a single Kriegserlebnis, as the chapter shows, Jews were united in the hope, as they joined thousands of other German men rushing to the colors in 1914, that the spirit of national unity would obliterate antisemitic stereotypes. Their participation in the immense violence of an industrialized war led to the formation of powerful bonds with gentile Germans, fueling Jewish hopes that the war would be the culmination of the long struggle for social acceptance.