Encapsulation and Characterization of Nanoemulsions Based on an Anti-Oxidative Polymeric Amphiphile for Topical Apigenin Delivery

Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical field. To address this issue, this study developed nanoemulsions (NEs) using an anti-oxidative polymeric amphiphile, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), hydrogenated soy lecithin (HL), black soldier fly larvae (BSFL) oil, and avocado (AV) oil through pre-homogenization and ultrasonication method. Addition of TPGS (weight ratios 100 and 50% as compared to HL) into NEs effectively reduced particle size and phase transition region area of NEs with pure HL. Incorporation of Apig into NEs made particle size increase and provided a disorder effect on intraparticle molecular packing. Nevertheless, the encapsulation efficiency of NEs for Apig approached to about 99%. The chemical stability of Apig was significantly improved and its antioxidant ability was elevated by incorporation with BSFL oil and AV oil NEs, especially for NEs with single TPGS. NEs with single TPGS also exhibited the best Apig skin deposition. For future application of topical Apig delivery, NEs-gel was formed by the addition of hyaluronic acid (HA) into NEs. Their rheological characteristics were dominated by the surfactant ratios of HL to TPGS.

Correlation magnetodynamics equations taking into account the uniaxial quadratic correction in the approximation of the one-particle distribution function

The system of equations for correlation magnetodynamics (CMD) is based on the Bogolyubov chain and approximation of the two-particle distribution function taking into account the correlations between the nearest neighbors. CMD provides good agreement with atom-for-atom simulation results (which are considered ab initio), but there is some discrepancy in the phase transition region. To solve this problem, a new system of CMD equations is constructed, which takes into account the quadratic correction in the approximation of the one-particle distribution function. The system can be simplified in a uniaxial case.

QCD susceptibilities in the presence of the chiral chemical potential

In this paper, chiral chemical potential [Formula: see text] is introduced to investigate the QCD susceptibilities and chiral phase transition within the Polyakov-loop-extended Nambu–Jona-Lasinio models in the mean-field approximation. We concentrate on the effect of chiral chemical potential on the phase diagram and the QCD susceptibilities. Moreover, it is worth noting that chiral chemical potential has more and more prominent impact on the susceptibilities and the phase diagram with the decrease of temperature based on our results, which coincides with the prediction that the chiral symmetry is dynamically broken in the first-order phase transition region and gets partly restored in the crossover region.

A New Approach to Generalization of Experimental Data on Heat Transfer to Fluids in Supercritical Region

The paper contains the results of analysis of heat transfer regimes in the case of forced turbulent flow of water and modeling fluids in channels of various configurations at supercritical pressures. Two new complex criteria were proposed for describing heat transfer in the pseudo-phase transition region. A system of equations suitable for the engineering calculation of heat transfer in fuel assemblies of nuclear supercritical water reactors is presented. A comparison of the calculations of heat transfer coefficient (HTC) with experimental data for the regimes of normal, deteriorated and mixed heat transfer is made.

Connecting the X(5)-β2, X(5)-β4, and X(3) models to the shape/phase transition region of the Interacting Boson Model

The parameter independent (up to overall scale factors) predictions of the X(5)-β2, X(5)-β4, and X(3) models, which are variants of the X(5) critical point symmetry developed within the framework of the geometric collective model, are compared to two- parameter calculations in the framework of the interacting boson approximation (IBA) model. The results show that these geometric models coincide with IBA parameters consistent with the phase/shape transition region of the IBA for boson numbers of physical interest (close to 10). 186Pt and 172Os are identified as good examples of X(3), while 146Ce, 174Os and 158Er, 176Os are identified as good examples of X(5)-β2 and X(5)-β4 behavior respectively.

Unveiling the optical parameters of vanadium dioxide in the phase transition region: a hybrid modeling approach

A universal hybrid modeling approach is developed to model VO2 in transition, revealing dynamic behavior of metallic inclusions and grain shapes.