With the apparent demise of globalization, many states are turning to regional solutions to achieve trade and development goals while institutional structure is fundamental to the strategic and managerial operations of such associations. This study seeks to understand the strategic costs and benefits, as well as the management opportunities and challenges, of a regional institution that maintains an informal structure while specifically examining the relationship between informal regional structure and member (national) resilience. This investigation develops a resilience framework and tests it against a unique structural form, the Pacific Alliance (Chile, Colombia, Mexico, and Peru), which operates without incorporation as a legal entity, without a centralized budget, and without a secretariat. This study reasons that an informal regional institution supports national resilience through an adaptation strategy but not an adaptability strategy and concludes that an informal regional model appears to support continual national development through the adoption of member ‘best practice'.