AĞ VEYA İP TIRMANMALI OYUN GRUPLARINDA KULLANILAN HALATLARIN ÜRETİLMESİ İLE İLGİLİ YENİ BİR YÖNTEM

Nowadays, climbing game tracks are available for children and for young people and adults. Some of these game tracks are climbing tracks designed as a net. Other ones are climbing groups comprising ropes and similar structures that are suitable for gripping by the hand. There are also game tracks that include both basic game tracks or have different designs while maintaining the fundamental characteristics. However, their common characteristic is that they allow people to try to grasp the rope or net tightly and play or do exercise with an experience close to the natural environment. For this reason, yarns (strings) made of materials such as nylon, polypropylene or polyester are either directly knitted or adhered with chemical adhesives on steel wires. However, during its use, the knitted or adhered yarns (strings) on the steel wire are opened, disorganized or worn. This causes the wires to corrode and / or wear under ambient conditions and thus shorten the life of the ropes. In this study, a solution has been developed to provide a rigid coating of these yarns on the wires. In our study, after the threads were wound on the wires, the steel wires were heated by an electromagnetic induction current and thus, the threads on the steel wires were softened with the effect of the heat. Then, during cooling, the threads harden and partially adhere to each other. Due to this heating process, the temperature was kept under control in order to prevent the properties of the steel wires from deteriorating. After the wires were produced, they were tested with tensile test, hardness and metallographic examination methods, and changes in their properties were controlled.

Impact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status

Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-enzymatic pathways (auto-oxidation). The oxidation processes lead to the synthesis of about 60 different oxysterols. Several oxysterols have physiological, pathophysiological, and pharmacological activities. The effects of oxysterols on cell death processes, especially apoptosis, autophagy, necrosis, and oxiapoptophagy, as well as their action on cell proliferation, are reviewed here. These effects, also observed in several cancer cell lines, could potentially be useful in cancer treatment. The effects of oxysterols on cell differentiation are also described. Among them, the properties of stimulating the osteogenic differentiation of mesenchymal stem cells while inhibiting adipogenic differentiation may be useful in regenerative medicine.

Diferenciação oxidativa em dispositivos temporários de ancoragem de Ti6Al4V e aço 316L – estudo piloto

The aim of this pilot study was to test the hypothesis that temporary anchoring devices (TADs) made of 316L steel are more resistant to corrosion even in fluorine environment than DATs manufactured in addition to titanium alloys, for this Potentiostat electrochemical measurements were performed. Materials and Methods: Four pieces of each material were tested in each test set, an application of Fusayama artificial saliva was used as an electrolytic solution in this study of in vitro corrosion, without fluorine in its composition and in a second moment with 1500ppM of fluorine in its composition. In the test, a cathodic polarization was performed by increasing this voltage for 5 minutes or until the corrosion pins were obtained. In artificial saliva containing up to 1500ppmF- this test was repeated with new samples of each material in artificial saliva solution without fluorine. Results: The results of the induction current scale were inserted into OriginPro8 software for making value graphs. As there was a small number of samples, in order not to violate the study’s reliability no statistical test was performed. Among all metal alloys currently used the Ti6Al4V alloy showed good resistance to corrosion in artificial saliva. However, the corrosion of these alloys occurs in contact with high fluorine concentration, unlike 316L steel alloy, which in addition to corrosion makes surface passivation.

Numerical Simulation on Stress Measurement with Eddy Current Thermography

Stress in components will lead to the change of material properties and even failure. Therefore, the assessment for the stress state of components is play an important role in testing industry. As a non-contact and multi-physical field nondestructive testing method, eddy current thermography (ECT) can be applied to detect non-homogeneous electromagnetic characteristics parameter distribution in conductive materials. Internal stress and its distribution in a material will affect the value of electromagnetic characteristic parameters. If induction current applied on conductive material, the Joule’s heat, which generate in the sample will lead to the temperature rise on the surface of the specimen by induction heating process. The temperature distribution on the specimen surface can be recorded by infra camera and stored as IR images or videos. The feature of the temperature distribution and its variation can be used to express the stress state in the specimen. It is concluded that there is an approximate linear relationship between the surface temperature appreciation and the loading force when the excitation source condition remains unchanged.

Memristor Synapse-Based Morris–Lecar Model: Bifurcation Analyses and FPGA-Based Validations for Periodic and Chaotic Bursting/Spiking Firings

Electromagnetic induction current sensed by the membrane potential in biological neurons can be characterized with a memristor synapse, which can be employed to demonstrate the real oscillating voltage patterns of Barnacle muscle fibers. This paper presents a 3D autonomous memristor synapse-based Morris–Lecar (abbreviated as m-ML) model, which is implemented through introducing a memristor synapse-based induction current to substitute the externally applied current in an existing 2D nonautonomous Morris–Lecar model. Making use of one- and two-parameter bifurcation plots and time-domain representations, diverse period-adding bifurcations as well as abundant periodic and chaotic burst firings are demonstrated. Through constructing the fold and Hopf bifurcation sets of fast spiking subsystem, bifurcation analyses of these chaotic and periodic burst firings are carried out. Moreover, the periodic and chaotic spiking firings and coexisting firing behaviors are illustrated by using one- and two-parameter bifurcation plots and local attraction basins. Finally, based on a field programmable gate array (FPGA) board, a compact digital electronic neuron is fabricated for the 3D m-ML model, from which periodic and chaotic bursting/spiking firings are experimentally measured to verify the results of the numerical simulations.

The Effect of Processing Variables on Powder Interlayer Bonding in Nickel-Based Superalloys

Powder Interlayer Bonding (PIB) has been considered as a lower-energy joining technology for nickel-based superalloys compared to conventional methods; such as friction welding. Typically; nickel-based superalloys exhibit high energy requirements for joining due to their high operating temperatures. However; PIB utilizes a localized temperature gradient created by an induction current; reducing the energy requirements for the process. PIB is a solid-state joining method that compresses and heats a powder interlayer between two faying surfaces to produce one joined workpiece. It has been successfully used to bond titanium alloys; and the objectives of this work were to explore its application as a joining method for nickel-based superalloys. Initial results showed that joining nickel-based superalloys via PIB is possible; and bondlines with very little porosity were observed. Further analysis showed that these bonded areas had lower porosity than the base material; suggesting PIB could be a successful joining method for difficult-to-join nickel-based superalloys.

P653 Efficacy and safety of an additional 8 weeks of tofacitinib induction therapy: Updated results of the OCTAVE Open study for tofacitinib 8-week induction non-responders

Background Tofacitinib is an oral, small-molecule JAK inhibitor for the treatment of ulcerative colitis (UC). Efficacy and safety of tofacitinib were demonstrated in three Phase 3, randomised, placebo-controlled trials in patients with moderate to severe UC.1 Patients who received tofacitinib 10 mg twice daily (BID) for 8 weeks (weeks) in OCTAVE Induction 1 and 2 (NCT01465763; NCT01458951) and did not achieve a clinical response (ie induction non-responders [IndNR]) could enter an ongoing, Phase 3, open-label, long-term extension (OLE) study (OCTAVE Open; NCT01470612). We present an update, as of May 2019, of previously published data up to December 2016 from the OLE study for IndNR patients.2 Methods IndNR patients received tofacitinib 10 mg BID in the OLE study. Patients who were still non-responders after an additional 8 weeks of induction were required to discontinue. Clinical response, remission and mucosal healing were evaluated up to Month (M)36 of the OLE study. Adverse events (AEs) and serious AEs (SAEs) are also presented. Results 429 IndNR patients enrolled in the OLE study, 295 of which received tofacitinib 10 mg BID during induction trials (Table). The proportions of patients with prior tumour necrosis factor inhibitor and baseline corticosteroid use were slightly higher in non-responders than responders at M2; other baseline characteristics were generally similar in responders and non-responders. At M2, 59.7%, 25.7% and 16.2% of patients achieved clinical response, mucosal healing and remission, respectively (as observed). Corresponding non-responder imputation and last observation carried forward values were 52.2%, 23.1% and 14.2% (Table). The table shows data up to M36. The proportions of patients with AEs, SAEs and discontinuations due to AEs for IndNR patients censored at M2 (52.2%, 3.7% and 2.4%, respectively) were similar to those for all patients in OCTAVE Induction 1 and 2 (tofacitinib: 55.4%, 3.8% and 3.9%; placebo: 56.4%, 6.0% and 4.3%), with no new safety risks identified (table). Conclusion The majority of patients who did not achieve clinical response to tofacitinib 10 mg BID for 8 weeks in the induction studies – and subsequently received an additional 8 weeks of tofacitinib 10 mg BID in the OLE study—achieved clinical response, with a considerable number of patients in remission and/or mucosal healing at M36. No new safety risks were observed in the additional 8 weeks of induction. These data support extended induction with an additional 8 weeks of tofacitinib for non-responders to 8-week induction. Current product labelling recommends 5 mg BID for maintenance in responders.3,4 References

Excitatory electromagnetic induction current enhances coherence resonance of the FitzHugh–Nagumo neuron

The effect of electromagnetic induction on neural firing activities has been widely investigated and has also been related to neural information coding. In this study, electromagnetic induction and Gaussian white noise (GWN) are introduced to the FitzHugh–Nagumo neuron, and the effect of induction current on GWN-induced coherence resonance (CR) is investigated. For an appropriate value of bias voltage source, the induction current is excitatory (respectively, inhibitory) when the gain of induction current is positive (respectively, negative). When the induction current is excitatory, the degree of CR is enhanced. When the induction current is inhibitory, however, the degree of CR is weakened. Furthermore, by varying the value of bias voltage source, we show that the degree of CR increases with the increase in the gain of induction current. Bifurcation analysis shows that the supercritical Hopf bifurcation point gets close to the resting state with the increase in the gain of induction current, which causes the increase in the degree of CR. The results of this study show that excitatory electromagnetic induction current can enhance noise-induced CR. This finding provides a possible way to modulate CR of the nervous system.