Synergistic Pd/Cu-catalysed regio- and stereoselective borylation of allenylic carbonates

A simple Pd/Cu-catalyzed borylation of allenylic carbonates with B2Pin2 was developed using cheap P(OEt)3 ligand. Under mild neutral condition, 2-boryl 1,3-butadienes could be obtained selectively in moderate to high yield....

Impact of Media-Based Age Stereotypes on Older Individuals’ Mental Health During the COVID-19 Pandemic

During the COVID-19 pandemic, stigmatization of older persons has increased in traditional and social media. It was unknown whether this negative messaging could be detrimental to the mental health of older individuals, and whether the relatively uncommon positive messaging about older individuals could benefit their mental health. To address these gaps, we designed age-stereotype interventions based on actual news stories that appeared during the pandemic. As expected, the exposure of older individuals to the negative-age-stereotype-messaging interventions led to significantly worse mental health (more anxiety and less peacefulness), compared to a neutral condition; in contrast, the positive-age-stereotype-messaging interventions led to significantly better mental health (less anxiety and more peacefulness), compared to a neutral condition. The results demonstrate the need for media messaging aimed at empowering older individuals during the pandemic and beyond.

Negative Emotion Reduces Visual Working Memory Recall Variability: A Meta-analytical Review

Negative emotion is often hypothesized to trigger a more deliberate processing mode.This effect can manifest as increased precision of information maintained in working memory (WM) captured by reduced WM recall variability. However, some recent evidence shows that WM representations are immune to any emotional influences. Here, we meta-analyze existing evidence based on data from 13 experiments across 491 participants who performed a delay estimation WM task under negative and neutral emotions. We find that negative emotion modestly reduces WM recall variability and increases recall failures relative to the neutral condition. These effects are moderated by participants’ self-report negative experiences during emotion induction. Collectively, these data suggest that negative emotion influences how muchand how well one can remember in WM.

Alterations in Functional Connectivity Measured by Functional Magnetic Resonance Imaging and the Relationship With Heart Rate Variability in Subjects After Performing Orgasmic Meditation: An Exploratory Study

Background: We measured changes in resting brain functional connectivity, with blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI), associated with a creative meditation practice that is augmented by clitoral stimulation and is designed to not only achieve a spiritual experience but to help individuals manage their most intimate personal relationships. Briefly, the meditative state is attained by both the male and female participants while the male stimulates the woman’s clitoris. The goal of this practice, called orgasmic meditation (OM), according to the practitioners is not sexual, but to use the focus on clitoral stimulation to facilitate a meditative state of connectedness and calm alertness between the two participants.Methods: fMRI was acquired on 20 pairs of subjects shortly following one of two states that were randomized in their order – during the OM practice or during a neutral condition. The practice is performed while the female is lying down on pillows with the clitoris exposed. During the practice, the male performs digital stimulation of the clitoris for 15 min. Resting BOLD image acquisition was performed at completion of the practice to assess changes in functional connectivity associated with the performance of the practice.Results: The results demonstrated significant changes (p < 0.05) in functional connectivity associated with the OM compared to the neutral condition. For the entire group there was altered connectivity following the OM practice involving the left superior temporal lobe, the frontal lobe, anterior cingulate, and insula. In female subjects, there was altered connectivity involving the cerebellum, thalamus, inferior frontal lobe posterior parietal lobe, angular gyrus, amygdala and middle temporal gyrus, and prefrontal cortex. In males, functional connectivity changes involved the supramarginal gyrus, cerebellum, and orbitofrontal gyrus, cerebellum, parahippocampus, inferior temporal gyrus, and anterior cingulate.Conclusion: Overall, these findings suggest a complex pattern of functional connectivity changes occurring in both members of the couple pair that result from this unique meditation practice. The changes represent a hybrid of functional connectivity findings with some similarities to meditation based practices and some with sexual stimulation and orgasm. This study has broader implications for understanding the dynamic relationship between sexuality and spirituality.

A Simple Gas-Kinetic Model For Dilute and Weakly Charged Plasma Micro-Jet Flows

This paper presents a simple model for slightly charged gas expanding into a vacuum from a planar exit. The number density, bulk velocity, temperature, and potential at the exit are given. The electric field force is assumed weaker than the convection term and is neglected in the analysis. As such, the quasi-neutral condition is naturally adopted and the potential field is computed with the Boltzmann relation. At far field, the exit degenerates as a point source, and simplified analytical formulas for flow and electric fields are obtained. The results are generic and offer insights on many existing models in the literature. They can be used to quickly approximate the flowfield and potential distributions without numerical simulations. They can also be used to initialize a simulation. Based on these results, more advanced models may be further developed.