Modern World Applications for Nano-Bio Materials: Tissue Engineering and COVID-19

Over the past years, biomaterials-based nano cues with multi-functional characteristics have been engineered with high interest. The ease in fine tunability with maintained compliance makes an array of nano-bio materials supreme candidates for the biomedical sector of the modern world. Moreover, the multi-functional dimensions of nano-bio elements also help to maintain or even improve the patients’ life quality most securely by lowering or diminishing the adverse effects of in practice therapeutic modalities. Therefore, engineering highly efficient, reliable, compatible, and recyclable biomaterials-based novel corrective cues with multipurpose applications is essential and a core demand to tackle many human health-related challenges, e.g., the current COVID-19 pandemic. Moreover, robust engineering design and properly exploited nano-bio materials deliver wide-ranging openings for experimentation in the field of interdisciplinary and multidisciplinary scientific research. In this context, herein, it is reviewed the applications and potential on tissue engineering and therapeutics of COVID-19 of several biomaterials. Following a brief introduction is a discussion of the drug delivery routes and mechanisms of biomaterials-based nano cues with suitable examples. The second half of the review focuses on the mainstream applications changing the dynamics of 21st century materials. In the end, current challenges and recommendations are given for a healthy and foreseeable future.

The Synthesis of Spherical Motion Generators in the Presence of an Incomplete Set of Attitudes

Proposed in this paper is a general methodology applicable to the synthesis of spherical motion generators in the presence of an incomplete set of finitely separated attitudes. The spherical rigid-body guidance problem in the realm of four-bar linkage synthesis can be solved exactly for up to five prescribed attitudes of the coupler link, and hence, any number of attitudes smaller than five is considered incomplete in this paper. The attitudes completing the set are determined to produce a linkage whose performance is robust against variations in the unprescribed attitudes. Robustness is needed in this context to overcome the presence of uncertainty due to the selection of the unspecified attitudes, that many a time are specified implicitly by the designer upon choosing, for example, the location of the fixed joints of the dyads. A theoretical framework for model-based robust engineering design is thus, recalled, and a methodology for the robust synthesis of spherical four-bar linkages is laid down. An example is included here to concretize the concepts and illustrate the application of the proposed methodology.

GLOBALLY ROBUST ENGINEERING DESIGN USING COMPLEXITY RULES

The paper aims at defining some complexity indices that would help designers of robotic mechanical systems to develop their goods with a globally robust design. Complexity is a relevant criterion in a globally robust design problem. Formerly a philosophical concept, it is nowadays well defined mathematically, but mainly used in computer science. However, design complexity is not defined yet in the literature. First, the notion of globally robust design and a design process model are set forth. Then, four design complexity indices are introduced. The first uses the notion of variance, the second is based on entropy, the third uses the notion of spectral richness, and the last one uses the notion of spectral noise. Finally, these four indices are compared by means of an analysis of the complexity of several distributions of subproducts.