scholarly journals Modern World Applications for Nano-Bio Materials: Tissue Engineering and COVID-19

2021 ◽  
Vol 9 ◽  
Author(s):  
Elda M. Melchor-Martínez ◽  
Nora E. Torres Castillo ◽  
Rodrigo Macias-Garbett ◽  
Sofia Liliana Lucero-Saucedo ◽  
Roberto Parra-Saldívar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Life Quality ◽  
Modern World ◽  
Foreseeable Future ◽  
Therapeutic Modalities ◽  
The Past ◽  
Health Related ◽  
Delivery Routes ◽  
Robust Engineering Design

Over the past years, biomaterials-based nano cues with multi-functional characteristics have been engineered with high interest. The ease in fine tunability with maintained compliance makes an array of nano-bio materials supreme candidates for the biomedical sector of the modern world. Moreover, the multi-functional dimensions of nano-bio elements also help to maintain or even improve the patients’ life quality most securely by lowering or diminishing the adverse effects of in practice therapeutic modalities. Therefore, engineering highly efficient, reliable, compatible, and recyclable biomaterials-based novel corrective cues with multipurpose applications is essential and a core demand to tackle many human health-related challenges, e.g., the current COVID-19 pandemic. Moreover, robust engineering design and properly exploited nano-bio materials deliver wide-ranging openings for experimentation in the field of interdisciplinary and multidisciplinary scientific research. In this context, herein, it is reviewed the applications and potential on tissue engineering and therapeutics of COVID-19 of several biomaterials. Following a brief introduction is a discussion of the drug delivery routes and mechanisms of biomaterials-based nano cues with suitable examples. The second half of the review focuses on the mainstream applications changing the dynamics of 21st century materials. In the end, current challenges and recommendations are given for a healthy and foreseeable future.

scholarly journals Development of a modular, biocompatible thiolated gelatin microparticle platform for drug delivery and tissue engineering applications

2021 ◽  
Author(s):  
Hannah A Pearce ◽  
Yu Seon Kim ◽  
Emma Watson ◽  
Kiana Bahrami ◽  
Mollie M Smoak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stem Cell ◽  
Cell Attachment ◽  
Control Cell ◽  
Growth Factor Delivery ◽  
Limited Ability ◽  
The Past ◽  
Modular Platform ◽  
Microparticle Formation

Abstract The field of biomaterials has advanced significantly in the past decade. With the growing need for high-throughput manufacturing and screening, the need for modular materials that enable streamlined fabrication and analysis of tissue engineering and drug delivery schema has emerged. Microparticles are a powerful platform that have demonstrated promise in enabling these technologies without the need to modify a bulk scaffold. This building block paradigm of using microparticles within larger scaffolds to control cell ratios, growth factors and drug release holds promise. Gelatin microparticles (GMPs) are a well-established platform for cell, drug and growth factor delivery. One of the challenges in using GMPs though is the limited ability to modify the gelatin post-fabrication. In the present work, we hypothesized that by thiolating gelatin before microparticle formation, a versatile platform would be created that preserves the cytocompatibility of gelatin, while enabling post-fabrication modification. The thiols were not found to significantly impact the physicochemical properties of the microparticles. Moreover, the thiolated GMPs were demonstrated to be a biocompatible and robust platform for mesenchymal stem cell attachment. Additionally, the thiolated particles were able to be covalently modified with a maleimide-bearing fluorescent dye and a peptide, demonstrating their promise as a modular platform for tissue engineering and drug delivery applications.

Nanostructured Calcium-based Biomaterials and their Application in Drug Delivery

2020 ◽  
Vol 27 (31) ◽  
pp. 5189-5212 ◽  
Author(s):  
Li-Juan Yi ◽  
Jun-Feng Li ◽  
Ming-Guo Ma ◽  
Ying-Jie Zhu
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bone Repair ◽  
Antibacterial Agents ◽  
Recent Progress ◽  
Review Article ◽  
Future Perspectives ◽  
Comprehensive Review ◽  
The Past ◽  
Biomedical Fields

In the past several decades, various types of nanostructured biomaterials have been developed. These nanostructured biomaterials have promising applications in biomedical fields such as bone repair, tissue engineering, drug delivery, gene delivery, antibacterial agents, and bioimaging. Nanostructured biomaterials with high biocompatibility, including calcium phosphate, hydroxyapatite, and calcium silicate, are ideal candidates for drug delivery. This review article is not intended to offer a comprehensive review of the nanostructured biomaterials and their application in drug delivery but rather presents a brief summary of the recent progress in this field. Our recent endeavors in the research of nanostructured biomaterials for drug delivery are also summarized. Special attention is paid to the synthesis and properties of nanostructured biomaterials and their application in drug delivery with the use of typical examples. Finally, we discuss the problems and future perspectives of nanostructured biomaterials in the drug delivery field.

scholarly journals Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Hoda Elkhenany ◽  
Azza El-Derby ◽  
Mohamed Abd Elkodous ◽  
Radwa A. Salah ◽  
Ahmed Lotfy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Growth Factors ◽  
Amniotic Membrane ◽  
Clinical Applications ◽  
Past Century ◽  
The Past ◽  
Potent Growth ◽  
Topical Applications

AbstractThe amniotic membrane (Amnio-M) has various applications in regenerative medicine. It acts as a highly biocompatible natural scaffold and as a source of several types of stem cells and potent growth factors. It also serves as an effective nano-reservoir for drug delivery, thanks to its high entrapment properties. Over the past century, the use of the Amnio-M in the clinic has evolved from a simple sheet for topical applications for skin and corneal repair into more advanced forms, such as micronized dehydrated membrane, amniotic cytokine extract, and solubilized powder injections to regenerate muscles, cartilage, and tendons. This review highlights the development of the Amnio-M over the years and the implication of new and emerging nanotechnology to support expanding its use for tissue engineering and clinical applications. Graphical Abstract

scholarly journals Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application

2012 ◽  
Vol 2 (3) ◽  
pp. 292-306 ◽  
Author(s):  
Chengtie Wu ◽  
Jiang Chang
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Growth Factor Delivery ◽  
Bioactive Glasses ◽  
The Past

The impact of bone diseases and trauma in the whole world has increased significantly in the past decades. Bioactive glasses are regarded as an important bone regeneration material owing to their generally excellent osteoconductivity and osteostimulativity. A new class of bioactive glass, referred to as mesoporous bioglass (MBG), was developed 7 years ago, which possess a highly ordered mesoporous channel structure and a highly specific surface area. The study of MBG for drug/growth factor delivery and bone tissue engineering has grown significantly in the past several years. In this article, we review the recent advances of MBG materials, including the preparation of different forms of MBG, composition–structure relationship, efficient drug/growth factor delivery and bone tissue engineering application. By summarizing our recent research, the interaction of MBG scaffolds with bone-forming cells, the effect of drug/growth factor delivery on proliferation and differentiation of tissue cells and the in vivo osteogenesis of MBG scaffolds are highlighted. The advantages and limitations of MBG for drug delivery and bone tissue engineering have been compared with microsize bioactive glasses and nanosize bioactive glasses. The future perspective of MBG is discussed for bone regeneration application by combining drug delivery with bone tissue engineering and investigating the in vivo osteogenesis mechanism in large animal models.

A Review on Fast Dissolving Tablet

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Sagar T. Malsane ◽  
Smita S. Aher ◽  
R. B. Saudagar
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Research Area ◽  
Oral Route ◽  
Dosage Forms ◽  
The Novel ◽  
The Past ◽  
Orally Disintegrating Tablets ◽  
Novel Drug ◽  
Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

The concept of the flat earth in the holy scripture

2020 ◽  
Vol 1 (100) ◽  
pp. 77-82
Author(s):  
V.P. Kultenko ◽  
◽  
K.M. Mamchur ◽  
Keyword(s):  
Old Testament ◽  
Space Exploration ◽  
Practical Experience ◽  
Modern World ◽  
Cultural Experience ◽  
Religious Texts ◽  
Sacred Texts ◽  
The Past

The article deals with the concept of flat Earth. There has a adherents and defenders in the modern world, despite the solid age of heliocentric teaching. Flat Earth apologists point out, that the evidence in favor of the scientific heliocentric theory is held on confidence. People should trust the testimony of astronauts, space exploration data, and more. However, the vast majority of people cannot verify this data from their own practical experience. If science is a criterion for truth, then the heliocentric concepts and flat Earth are far removed from this criterion. Moreover, in the cultural experience of the past we can find arguments in favor of the concept of a flat Earth. These testimonies are contained, in particular, in the Old Testament Bible, the sacred texts of Christianity and Judaism. The mythological and religious texts of other nations and cultures also refer to the idea of a flat Earth.

From Market to Bazaar: Metamorphosis of Commercialization of the Past in the Modern World

2019 ◽  
pp. 49-58
Author(s):  
A. Linchenko ◽  
◽  
O. Golovashina ◽  
D. Anikin ◽  
◽  
...  
Keyword(s):  
Modern World ◽  
The Past

Novel Topical Drug Delivery Approaches for the Management of Psoriasis

2020 ◽  
Vol 13 (5) ◽  
pp. 5062-5068
Author(s):  
Bhumika Kumar ◽  
Monika Targhotra ◽  
Rohan Aggarwal ◽  
Sahoo P.K
Keyword(s):  
Drug Delivery ◽  
Life Quality ◽  
Skin Area ◽  
Treatment Approaches ◽  
Treatment Regimens ◽  
Skin Cell ◽  
Conventional Drug ◽  
Severity Of The Disease ◽  
Novel Drug ◽  
Disease Location

Psoriasis is one of the most stern and persistent autoimmune disease which affects about 1-3% population around the globe.  It influences an individual’s life quality by hindering them physically, socially and emotionally. The hyperproliferation of keratinocytes leads to excessive growth of skin cell which causes scaling and formation of plaques. Psoriasis can be mild moderate or severe depending on the percentage of skin area affected. Based on severity of the disease, location and the type of psoriasis, the treatment approaches can vary. Treatment regimens for psoriasis include topical therapies, systemic therapies and phototherapy. Conventional drug delivery approaches face various disadvantages therefore a need for better novel drug delivery system is required. The review paper focuses at providing a broad aspect of psoriasis and the novel treatment approaches which can help in tackling the disease.  

Scaffolds for Drug Delivery in Tissue Engineering

2008 ◽  
Vol 1 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Heart Diseases ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
The Body ◽  
Patient Specific ◽  
In Situ Gel ◽  
Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

Hydrogels as Antibacterial Biomaterials

2018 ◽  
Vol 24 (8) ◽  
pp. 843-854 ◽  
Author(s):  
Weiguo Xu ◽  
Shujun Dong ◽  
Yuping Han ◽  
Shuqiang Li ◽  
Yang Liu
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Oxygen Permeability ◽  
Structural Diversity ◽  
High Water ◽  
Clinical Applications ◽  
High Water Content ◽  
Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

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