AbstractRepresenting at least five percent of world GDP, corruption is a great challenge in general, and especially associated with sustainable business, both nationally and internationally. In this chapter, I reflect on how to address corruption and anti-corruption practices. Typical forms of corruption include bribery, facilitation payments, gifts, hospitality and expenses, political contributions, charitable contributions, sponsorships, voluntary community contributions, trading in influence, and conflict of interest and impartiality. Corruption leads to weak institutions and injustice, less respect for rights, denial of basic services, and several of the world’s environmental damage and tragedies are associated with corruption. Studies show that almost half of the companies have experienced fraud over the past two years. This chapter addresses the corruption challenges, how they are addressed by corporations and key international laws as well as challenges associated with norms and behaviors. How to detect and avoid corruption receives key attention. As anti-corruption is a huge topic and challenge, and only limited space is available in the book, the topic is presented from a more general perspective. Even though anti-corruption is often left out when talking about sustainability, it cannot be excluded from a book on sustainability and responsibility.