The subtle nuances of intranasal corticosteroids

Background In the specialty of Otolaryngology – Head and Neck Surgery, intranasal corticosteroids are the mainstay treatment for inflammatory processes within the nasal cavity. All too often, physician prescribing patterns are based on previous training, personal experience, and interactions with industry. The purpose of this commentary is to review the nuances of each intranasal corticosteroid. Commentary There are nine intranasal corticosteroids approved for use in Canada. Each are discussed in detail, including their indication, bioavailability, effects on intranasal environment, and factors around patient adherence. Off-label use of budesonide irrigations is also discussed and cost information is presented in reference format for all available intranasal corticosteroids. Conclusion Although the efficacy of each intranasal corticosteroid has been shown to be similar, prescribing should be tailored based on bioavailability, intranasal environment, and factors that impact patient adherence such as dosing, cost and tolerability. Graphical abstract

AI-Driven Multiscale Simulations Illuminate Mechanisms of SARS-CoV-2 Spike Dynamics

ABSTRACTWe develop a generalizable AI-driven workflow that leverages heterogeneous HPC resources to explore the time-dependent dynamics of molecular systems. We use this workflow to investigate the mechanisms of infectivity of the SARS-CoV-2 spike protein, the main viral infection machinery. Our workflow enables more efficient investigation of spike dynamics in a variety of complex environments, including within a complete SARS-CoV-2 viral envelope simulation, which contains 305 million atoms and shows strong scaling on ORNL Summit using NAMD. We present several novel scientific discoveries, including the elucidation of the spike’s full glycan shield, the role of spike glycans in modulating the infectivity of the virus, and the characterization of the flexible interactions between the spike and the human ACE2 receptor. We also demonstrate how AI can accelerate conformational sampling across different systems and pave the way for the future application of such methods to additional studies in SARS-CoV-2 and other molecular systems.ACM Reference FormatLorenzo Casalino1†, Abigail Dommer1†, Zied Gaieb1†, Emilia P. Barros1, Terra Sztain1, Surl-Hee Ahn1, Anda Trifan2,3, Alexander Brace2, Anthony Bogetti4, Heng Ma2, Hyungro Lee5, Matteo Turilli5, Syma Khalid6, Lillian Chong4, Carlos Simmerling7, David J. Hardy3, Julio D. C. Maia3, James C. Phillips3, Thorsten Kurth8, Abraham Stern8, Lei Huang9, John McCalpin9, Mahidhar Tatineni10, Tom Gibbs8, John E. Stone3, Shantenu Jha5, Arvind Ramanathan2∗, Rommie E. Amaro1∗. 2020. AI-Driven Multiscale Simulations Illuminate Mechanisms of SARS-CoV-2 Spike Dynamics. In Supercomputing ’20: International Conference for High Performance Computing, Networking, Storage, and Analysis. ACM, New York, NY, USA, 14 pages. https://doi.org/finalDOI

ERRATUM TO: IMPLEMENTATION OF INTERNET-BASED EMERGENCY MEDICAL SERVICE: A SOLUTION TO IMPROVE RESPONSE TIME IN OUT-OF-HOSPITAL CARDIAC ARREST AND ITS POTENTIAL APPLICATION IN INDONESIA

After the publication of the article (Fahmi & Nurachmah, 2018), it has been brought to our attention that the wrong title was used on the initial publication. The correct title of this article is “Implementation of Internet-based emergency medical service: A solution to improve response time in out-of-hospital cardiac arrest and its potential application in Indonesia.” The original version of the article has been updated to reflect this.The reference format in this article has also been updated.The publisher apologizes for the errors.The corrected article can be seen in the following link: https://doi.org/10.33546/bnj.573

ERRATUM TO: FACTORS RELATED TO DEPRESSION AMONG OLDER PEOPLE LIVING IN CIMAHI, WEST JAVA PROVINCE, INDONESIA

After publication of the article (Gustryanti et al., 2017), it has been brought to our attention that the wrong title was used on initial publication. The correct title of this article is “Factors related to depression among older people living in Cimahi, West Java Province, Indonesia”. The original version of the article has been updated to reflect this.In addition, the reference format in this article has also been updated. The publisher apologizes for the minor errors.The corrected article can be seen in the following doi: https://doi.org/10.33546/bnj.50

ERRATUM TO: CAREGIVERS’ EXPERIENCE IN MEETING SELF-CARE NEEDS OF ADOLESCENTS WITH AUTISM SPECTRUM DISORDER: A QUALITATIVE STUDY

After publication of the article (Lestari et al., 2017), it has been brought to our attention that the wrong title was used on initial publication. The correct title of this article is “Caregivers’ experience in meeting self-care needs of adolescents with autism spectrum disorder: A qualitative study”. The original version of the article has been updated to reflect this.In addition, the reference format in this article has also been updated. The corrected article can be seen in the following link https://doi.org/10.33546/bnj.123The publisher apologizes for the errors.

Bartlett's Medical Management of HIV Infection

With more than 30 million people living with HIV, nearly 2 million new HIV infections, and 1 million deaths in 2017 globally, the HIV epidemic continues to exert a considerable deleterious impact on the health of individuals, communities, and the economic growth of nations. However, remarkable advances have also been achieved: improvements in our scientific understanding of the biology of HIV, how it causes disease, and its prevention and treatment, coupled with unprecedented multi-sectoral global efforts, have resulted in rendering HIV infection essentially a manageable chronic disease. The 17th edition of Bartlett’s Medical Management of HIV Infection offers the best-available clinical guidance for treatment of patients with HIV, all in a portable, quick-reference format. Edited by preeminent and pioneering authorities in HIV research and clinical care, it has earned its status as the definitive work for physicians, physician assistants, nurse practitioners, pharmacists, and anyone working in the care of persons with HIV.