We studied biochemical characteristics of the lower limbs of patients with diabetic foot (DF) to develop custom orthopedic insoles. In this study of 88 patients with diabetes, 58 had a normal foot appearance, 18 had plantar calluses, and 12 had valgus feet. The maximum pressure applied
to the left and right plantar of patients with DF is under the third metatarsal, and the peak areas of the left and right feet are below the first metatarsal. Pain and American Orthopedic Foot and Ankle Society scores were reduced after one year of wearing modified orthopedic insoles versus
unmodified insoles. After one year of wearing the insole, the pressure was reduced in the left and right feet of both groups, but the intervention group showed a more significant reduction than the controls. The swing time was shorter in the intervention group and the incidence of DF ulcers
was 6.81% higher in the control group. Thus, lower limb biomechanics differ in patients with DF, most of who experience calluses and hallux valgus. Modified orthopedic insoles provide improved sole pain, ankle-foot joint function, and distribution of plantar pressure, and incidence of DF ulcers.