Changes in micro- and central hemodynamic parameters in rats under the action of acetylsalicylic acid and its coordination compounds with metals

Introduction. The cutaneous blood circulation is a representative model both for studying the mechanisms of vascular diseases and for assessing the current state of the central hemodynamics in preclinical researches of various chemical compounds. Aim. The changes in the parameters of cutaneous microcirculation and central hemodynamics (heart rate and blood pressure) were studied in the animals under the action of acetylsalicylic acid and its coordination compounds with cations of cobalt, zinc, nickel and manganese at a dose of 20 mg/kg. Materials and methods. The research was conducted using the laser Doppler flowmetry method on the Lazma-MC device (manufactured by RPE Lazma, Russia) and the NIBP200A system (Biopac Systems, Inc., USA). Results. The study shows that animals develop bradycardia, and microcirculation and central hemodynamics change in two ways after the introduction of acetylsalicylic acid and the tested metal salicylates. These ways are hypotension-related hyperemia (acetylsalicylic acid and cobalt salicylate) and ischemia (zinc, nickel and manganese salicylates) associated with hypertension. Conclusion. The obtained data confirm the cardiotropic activity of new coordination compounds. The data also prove that the generation of the acetylsalicylic acid derivatives allows enhancing it physiological effects, as well as obtaining completely new molecules. The molecules are different from the precursor one and are necessary for the production of effective drugs.

INVESTIGATION OF THE INTERACTION OF UDP METALS WITH PRODUCTS OF THERMAL DECOMPOSITION OF TETRAZOLE BINDER

В статье приводятся экспериментальные исследования ультрадисперсных металлических порошков алюминия, меди, железа, вольфрама, титана, цинка, никеля, сплавов меди с алюминием, меди с железом и латуни. Описаны термические свойства их смесей с метилполивинилтетразолом, пластифицированным динитратпропиленгликолем; указаны численные величины значимых характеристик.Результаты исследования показали, что существенное количество тепла выделяется при нагреве порошков алюминия, цинка, титана и железа; при нагреве смесей со связующим, наилучшие результаты соответствуют сплаву меди с железом, алюминию и сплаву меди с алюминием. The article presents experimental studies of ultrafine metal powders of aluminum, copper, iron, tungsten, titanium, zinc, nickel, alloys of copper with aluminum, copper with iron and brass. The thermal properties of their mixtures with methyl polyvinyl tetrazole and plasticized propylenglycoldinitrate are described; numerical values of significant characteristics are indicated.The results of the study showed that a significant amount of heat is released when heating aluminum, zinc, titanium and iron powders; when heating mixtures with a binder, the best results correspond to an alloy of copper with iron, aluminum and an alloy of copper with aluminum.

The effect of mixed rot from the present tinder (Fomes fomentarius (L.:Fr.) Gill.) on the accumulation of heavy metals in the hanging birch (Betula pendula Roth.)

A study was conducted on the effect of mixed rot from the present tinder on the accumulation of heavy metals (copper, zinc, nickel, cadmium, lead, cobalt, iron) by hanging birch Keywords: real tinder, mixed rot, heavy metals, hanging birch.

Determination of Heavy Metals (Lead, Zinc, Nickel and Cadmium) in Medicinal Plants (Scent Leaf and Pawpaw) in Bayelsa State, Nigeria

Aims: This study investigated the level of zinc, nickel, lead and cadmium in selected medicinal plants - Scent Leaf (Ocimum gratissimum) and Pawpaw (Carica papaya) that are traditionally used in alternative medicine in Amassoma community, Bayelsa State, Nigeria. Study Design: Scent leaf (Ocimum gratissimum) and Pawpaw (Carica papaya) from where these plants are grown were randomly collected for heavy metal analysis from within Amassoma community in Southern Ijaw Local Government Area of Bayelsa State, Nigeria Place and Duration of Study: This study was carried out in Biological Sciences, Faculty of Science, Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State between March 2019 to September 2019 Methodology: Scent leaf (Ocimum gratissimum) and Pawpaw (Carica papaya) were digested and analyzed for heavy metals using Atomic Absorption Spectrophotometer (AAS, model S471096). The method used was wet-ashing method for the analysis. Results: The result showed that the concentration of Lead in the pawpaw fruit with 5.99mg/kg and pawpaw seed with 3.72mg/kg, were above the WHO permissible limit. While the concentration of Cadmium in the pawpaw fruit, pawpaw leaf, pawpaw seed and scent leaf with 1.32mg/kg, 0.96mg/kg, 0.21mg/kg, and 0.59mg/kg, were all above the permissible limits. Again, Zinc in the pawpaw fruit, pawpaw leaf, pawpaw seed and scent leaf were 2.52mg/kg, 2.53mg/kg, 5.30mg/kg, and 0.79mg/kg respectively, and these are also above the permissible limit. While that of the concentration of Nickel in the pawpaw fruit, pawpaw leaf, pawpaw seed and scent leaf were observed to be within permissible limit. Conclusion: It is therefore recommended that caution should be taken when such plants are to be used as alternative to conventional medicine as excess of it could pose the risk of bioaccumulation and possible health effects in humans.

Preparation and Properties of Mattel Oxide Nanoparticles by Pulse Laser Ablation in Liquid as Photo-Catalysis

Zinc, nickel and silver oxide were prepared by the method of pulsed ablation laser in liquid, with different preparation conditions, where the number of pulses was changed (25, 50 and 75) and the frequency was 1 Hz and the energy was 600 mJ and at room temperature. We have used UV-visible spectroscopy, field emission scanning electron microscopy (FSEM), the EDX system, then these materials were added to the local dye and the photo-catalytic activity was applied to them using a UV-500 lamp for different periods of time (0, 30, 60 and 120 mint) and they acted as photo-catalysts.