Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells

Background Testosterone signaling mediates various diseases, such as androgenetic alopecia and prostate cancer. Testosterone signaling is mediated by the androgen receptor (AR). In this study, we fortuitously found that primary and immortalized dermal papilla cells suppressed AR expression, although dermal papilla cells express AR in vivo. To analyze the AR signaling pathway, we exogenously introduced the AR gene via a retrovirus into immortalized dermal papilla cells and comprehensively compared their expression profiles with and without AR expression. Results Whole-transcriptome profiling revealed that the focal adhesion pathway was mainly affected by the activation of AR signaling. In particular, we found that caveolin-1 gene expression was downregulated in AR-expressing cells, suggesting that caveolin-1 is controlled by AR. Conclusion Our whole transcriptome data is critical resources for discovery of new therapeutic targets for testosterone-related diseases.

Entrepreneurial Orientation and Dynamic Capabilities

Currently, small and medium enterprises that are family businesses (SMEFs) assume an important role in the global economy. Further, innovation and flexibility became vital to firms' survival and prosperity in the market during these volatile times. Firms should not only possess critical resources, but also be able to recombine them. Characterized by resource restrictions, SMEFs can rely on dynamic capabilities to access resources and be competitive in the market. In this regard, networking capabilities (NC) and resource combinations (RC) such as exploitative and explorative product development and on market-related capabilities emerge as key dynamic capabilities. This chapter examines the role of Entrepreneurial Orientation (EO) on NC and RC. Using a qualitative method of in-depth case study, the chapter analyzes 12 Portuguese SMEFs.

Reconstructing Pragmatism

The figure of Richard Rorty stands in complex relation to the tradition of American pragmatism. On the one hand, his intellectual creativity, lively prose, and bridge-building fueled the contemporary resurgence of pragmatism. On the other, his polemical claims and selective interpretations function as a negative, fixed pole against which thinkers of all stripes define themselves. Virtually all pragmatists on the contemporary scene, whether classical or “new,” Deweyan, Jamesian, or Peircean, use Rorty as a foil to justify their positions. The resulting divisions and internecine quarrels threaten to thwart and fragment the tradition’s creative potential. More caricatured than understood, the specter of Rorty is blocking the road of inquiry and future development of pragmatism. Reconstructing Pragmatism moves beyond the Rortyan impasse by providing what has been missing for decades: a constructive, nonpolemical account of Rorty’s relation to classical pragmatism. The first book-length treatment of Rorty’s intellectual debt to the early pragmatists, it establishes his selective appropriations not as misunderstandings or distortions but as a sustained, intentional effort to reconstruct their thinking. Featuring chapters devoted to five key pragmatist thinkers—Charles Sanders Peirce, William James, John Dewey, Josiah Royce, and Jane Addams—the book draws on archival sources and the full scope of Rorty’s writings to challenge prevailing misconceptions and caricatures. By illuminating the critical resources, still largely untapped, that Rorty offers for articulating classical pragmatism’s ongoing relevance, the book reveals limitations in received images of the classical pragmatists and opens up new modes of understanding pragmatism and why it matters today.

Television Series as Critical Theories: From Current Identitarianism to Levinas. American Crime, The Sinner, Sharp Objects, Unorthodox

Critical theory with emancipatory aims today to find a source of regeneration in ordinary cultures, and in particular, in TV series. Certain series can play a role in reinventing critical theories, drawing on the tradition of the Frankfurt School but shifting some of that School’s formulations through contact with current forms of interpretive sociology and pragmatic sociology. This requires a cross-border dialogue between the “language game” of TV series and the “knowledge game” of political theory, to use concepts inspired by Ludwig Wittgenstein. In this article, I will focus on four series: seasons 1 of American Crime (2015) and The Sinner (2017); Sharp Objects (2018); and Unorthodox (2020). The resources provided by these cultural works can help us formulate a critical decoding of important aspects of the current ideological context, in particular, the intersecting identitarian and ultra-conservative tendencies we find in France, Europe, the United States, and Brazil. These critical resources bear affinities to a political philosophy of the opening of being inspired by the ethical reflections of Emmanuel Levinas.

An Empirical Study on Multiple Corporate Directorships in New Zealand: A New Interpretation of Selected Governance Theories

<p>This thesis contributes to the literature on Multiple Directorships (MDS) by providing new evidence that prestigious MDS are value enhancing relative to non-prestigious MDS for New Zealand listed companies. The recent debate surrounding the reasons for including multiple (busy) directors on the board as well as the diverse conclusions of prior studies on MDS draw attention to the fact that theoretically-informed possibilities of MDS are yet to be explored, especially in a setting where the higher incidence of MDS has been driven by a unique institutional environment. New Zealand is one example of such a setting. To explore one aspect of these issues, this research first asks whether there are firm ‘performance’ differences between prestigious MDS and non-prestigious MDS. The results of initial tests show that prestigious MDS have a positive influence on performance outcomes for their organizations, while there is a negative or no significant relationship between non-prestigious MDS and firm performance. These results also suggest a one-way causal effect of prestigious MDS on firm performance. Having determined the better value of prestigious MDS, the subsequent and primary question of this thesis is to explore ‘why’ differences may exist between the two categories of MDS. Three corporate governance theories, namely, Resource Dependence, Agency and Managerial Hegemony are employed to differentiate, and thus to help explain, the sources of prestigious MDS success. The results of the second set of tests reveal that the differences between prestigious and non-prestigious MDS can primarily be explained by firms’ needs for easier acquisition of critical resources, which are often associated with the level of agency conflicts and the presence of powerful CEOs. Empirical evidence then suggests that prestigious MDS potentially create value for New Zealand companies in terms of facilitating access to critical resources and minimizing agency conflicts as well as CEO influence on board oversight. The findings have potential policy implications, especially in an export-oriented economy with geographic isolation and small scale of population, such as New Zealand. Regulators, for instance, the Financial Markets Authority and Institute of Directors should be mindful of the need to retain expert (prestigious) directors and cautiously evaluate before initiating any new regulation regarding MDS.</p>

An Empirical Study on Multiple Corporate Directorships in New Zealand: A New Interpretation of Selected Governance Theories

<p>This thesis contributes to the literature on Multiple Directorships (MDS) by providing new evidence that prestigious MDS are value enhancing relative to non-prestigious MDS for New Zealand listed companies. The recent debate surrounding the reasons for including multiple (busy) directors on the board as well as the diverse conclusions of prior studies on MDS draw attention to the fact that theoretically-informed possibilities of MDS are yet to be explored, especially in a setting where the higher incidence of MDS has been driven by a unique institutional environment. New Zealand is one example of such a setting. To explore one aspect of these issues, this research first asks whether there are firm ‘performance’ differences between prestigious MDS and non-prestigious MDS. The results of initial tests show that prestigious MDS have a positive influence on performance outcomes for their organizations, while there is a negative or no significant relationship between non-prestigious MDS and firm performance. These results also suggest a one-way causal effect of prestigious MDS on firm performance. Having determined the better value of prestigious MDS, the subsequent and primary question of this thesis is to explore ‘why’ differences may exist between the two categories of MDS. Three corporate governance theories, namely, Resource Dependence, Agency and Managerial Hegemony are employed to differentiate, and thus to help explain, the sources of prestigious MDS success. The results of the second set of tests reveal that the differences between prestigious and non-prestigious MDS can primarily be explained by firms’ needs for easier acquisition of critical resources, which are often associated with the level of agency conflicts and the presence of powerful CEOs. Empirical evidence then suggests that prestigious MDS potentially create value for New Zealand companies in terms of facilitating access to critical resources and minimizing agency conflicts as well as CEO influence on board oversight. The findings have potential policy implications, especially in an export-oriented economy with geographic isolation and small scale of population, such as New Zealand. Regulators, for instance, the Financial Markets Authority and Institute of Directors should be mindful of the need to retain expert (prestigious) directors and cautiously evaluate before initiating any new regulation regarding MDS.</p>

Tackling the Waves of COVID-19: A Planning Model for Intrahospital Resource Allocation

Background: The current pandemic requires hospitals to ensure care not only for the growing number of COVID-19 patients but also regular patients. Hospital resources must be allocated accordingly.Objective: To provide hospitals with a planning model to optimally allocate resources to intensive care units given a certain incidence of COVID-19 cases.Methods: The analysis included 334 cases from four adjacent counties south-west of Munich. From length of stay and type of ward [general ward (NOR), intensive care unit (ICU)] probabilities of case numbers within a hospital at a certain time point were derived. The epidemiological situation was simulated by the effective reproduction number R, the infection rates in mid-August 2020 in the counties, and the German hospitalization rate. Simulation results are compared with real data from 2nd and 3rd wave (September 2020–May 2021).Results: With R = 2, a hospitalization rate of 17%, mitigation measures implemented on day 9 (i.e., 7-day incidence surpassing 50/100,000), the peak occupancy was reached on day 22 (155.1 beds) for the normal ward and on day 25 (44.9 beds) for the intensive care unit. A higher R led to higher occupancy rates. Simulated number of infections and intensive care unit occupancy was concordant in validation with real data obtained from the 2nd and 3rd waves in Germany.Conclusion: Hospitals could expect a peak occupancy of normal ward and intensive care unit within ~5–11 days after infections reached their peak and critical resources could be allocated accordingly. This delay (in particular for the peak of intensive care unit occupancy) might give options for timely preparation of additional intensive care unit resources.

Save the Appearances! Toward an Arendtian Environmental Politics

Drawing critical resources from Hannah Arendt, this article argues for a revaluation of the appearances of nature in environmental political theory and practice. At a time when pervasive anthropogenic contamination threatens the very survival of vulnerable communities and species, it would be wrong to revive the timeworn mythos of nature as an untrammeled beauty. Instead, with Arendt’s help, I advocate an environmental politics rooted in an alternative aesthetic of nature, one that respects and seeks to protect earth’s diverse lifeforms for the sake of their strange, disquieting appearances of otherness. Earth’s living displays of alterity are valuable, I argue, for their propensity to upset the destructive logic of mass production and consumption and spur political action. In an Arendtian frame, we can better recognize interdependence between biological and political life and appreciate the role of nonhuman lifeforms in constituting spaces of appearance where human freedom and plurality may flourish.

De-picturing John A. Macdonald: Opportunities and Challenges of Representing Canada’s Past with Graphic History

This article explores the historiographical and methodological opportunities and challenges of graphic history to represent, interpret, and interrogate Canada’s past. Graphic history is a research-creation approach that combines word and picture to produce illustrated texts and comic book-style narratives. While I address important critiques about academic rigour, pedagogical value, and practical viability, I argue that graphic history has much potential to offer historians. By broadening our understanding of scholarly work, graphic histories can be accessible sources for wider audiences, critical resources for teaching and learning, and/or imaginative methods for engaging with historiographical issues. After examining the theories and practices of graphic history, I illustrate a graphic-text essay on the contested images of John A. Macdonald. Pictures of the first prime minister are well known to most Canadians in photograph, caricature, and statue, but his legacy has come under greater academic and public scrutiny, particularly regarding policies towards Indigenous peoples. I focus on Macdonald because debates over his commemoration are relevant to the ways in which historians represent and confront complicated pasts. I use related debates over statue removal and anxieties about erasure of history to explore deeper historiographic questions about representation, truth, presentism, and perspective. I argue that a graphic history approach is a medium for deconstructing, or, as I call it, de-picturing, a one-dimensional, dominant image of Macdonald on a pedestal, exhibited in bronze.

The Loss of Raw Material Criticality: Implications of the Collapse of Saudi Arabian Oil Exports

Raw material criticality has played an important role in geostrategic thinking, especially since the crisis surrounding the price and supply of rare earths at the beginning of the 2010s. However, once dependency and strategic importance grow too strong, substitution efforts will take place that could reduce or even eradicate the previous criticality. Critical resources rarely become obsolete very quickly. However, this could happen in the case of crude oil because climate policy is forcing defossilisation, but also because artificial scarcity is falling as a result of geostrategic rivalries that are causing oversupply. This article analyses this process and the possible consequences using Saudi Arabia as an example. The development of a green hydrogen industry has potential, but it should not be overestimated in view of the absorption capacity of the economy.