Work gives people dignity, income, and political voice but it also puts people at risk of premature death, jeopardizes self-sufficiency, and dominates workers’ lives. How a person experiences work profoundly influences well-being and lifetime success. How a society organizes work opportunities shapes public health, fairness, and democracy. This chapter describes how changes in modern capitalism have expanded a workforce that is low paid with few benefits, inadequately protected against workplace hazards, and lacking in economic security. It explains how deregulation, low wages, weakened labor laws, and the rise of the gig economy have worsened the life circumstances of millions of U.S. workers, threatening their physical and mental health. The chapter also describes how new forms of labor organizing and new coalitions have promoted pro-worker policies such as living wages, sick and parental leave, laws against wage theft, and universal health care and childcare.