Two to Tango: Untangling Inter-organ Communication Using Drosophila Melanogaster and Danio Rerio

In an organism, different organ systems are highly specialised for performing dedicated functions. However, it is increasingly becoming clear that the organ systems do not function in isolation but are rather extensively dependent on each other. This phenomenon is known as inter-organ communication and is a novel paradigm of exocrine signaling. In this minireview, we discuss the theoretical implications of this kind of crosstalk and the resources available for practical demonstration of the same. We focus on the fruit fly, Drosophila melanogaster, and the zebrafish, Danio rerio. Both the model organisms are amenable to genetic manipulation and have been largely used to address many pending questions in all the fields of biology using cutting-edge cellular, molecular, and imaging techniques and tools. Both the organisms also offer the advantages of having organ systems functionally equivalent to those of humans to dissect how the development and functions of organs are established in dialogue with others.

Regenerative tourism in Aotearoa New Zealand – A new paradigm for the VUCA world

PurposeThe paper provides a summary of the findings from GOOD Awaits – The Regenerative Tourism New Zealand (NZ) Podcast and envisions a regenerative future for tourism in Aotearoa.Design/methodology/approachThis paper is based on the findings from the GOOD Awaits Podcast, a series of interviews with pioneers and practitioners of regenerative tourism. The podcast was created as a platform for the collective discovery of a new way forward for tourism in the wake of COVID-19, and the series provides a detailed summary of the regenerative tourism movement in NZ.FindingsThrough these interviews, a vision for a regenerative visitor economy in Aotearoa emerged. This new model is rooted in indigenous knowledge and living systems theory. It is a paradigm shift that allows us to see tourism as a living ecosystem and requires innovative economic models, such as social entrepreneurship, systems level changes to the way tourism operates and is governed, local tourism solutions with community thriving as the primary aim and much more collaboration both within tourism and across sectors.Originality/valueRegenerative tourism is an emerging model and one that is rapidly gaining traction in NZ and globally. The GOOD Awaits podcast is a unique, thoughtful and practical demonstration of what this model could look like in Aotearoa. It demonstrates the potential and feasibility of regenerative tourism practice, and the response has shown the desire for these conversations at a national and international scale. This paper is an accessible summary of the podcast's first season and has value for anyone interested in the regenerative tourism movement in Aotearoa.

Champions of Social Procurement in the Australian Construction Industry: Evolving Roles and Motivations

There has been a recent proliferation of social procurement policies in Australia that target the construction industry. This is mirrored in many other countries, and the nascent research in this area shows that these policies are being implemented by an emerging group of largely undefined professionals who are often forced to create their own roles in institutional vacuums with little organisational legitimacy and support. By mobilising theories of how organisational champions diffuse innovations in other fields of practice, this paper contributes new insights into the evolving nature of these newly emerging roles and the motivations which drive these professionals to overcome the institutional inertia they invariably face. The results of semi-structured interviews, with fifteen social procurement champions working in the Australian construction industry, indicate that social procurement champions come from a wide range of professional backgrounds and bring diverse social capital to their roles. Linked by a shared sense of social consciousness, these champions challenge traditional institutional norms, practices, supply chain relationships, and traditional narratives about the concepts of value in construction. We conclude that, until normative standards develop around social procurement in the construction industry, its successful implementation will depend on external institutional pressures and the practical demonstration of what is possible in practice within the performative constraints of traditional project objectives.

Control of Upper Limb Active Prosthesis Using Surface Electromyography

Electromyographic prosthesis with higher degrees of freedom is an expanding area of research. In this paper, active prosthesis with four degrees of freedom has been investigated, which can be used to fit a limb with amputation below elbow. The system comprises of multichannel inputs which correspond to the flexion and extension as well as supination and pronation. To find maximum surface neural activity, accurate placement of electrodes has been carried out on 10 subjects aged between 22-30 years. Signals (0-500 hertz) acquired from contracting voluntary muscles with minimum cross talk and common mode noise. Clean filtered EMG signal is then amplified precisely. Finally digitization is being done to drive bionic hand. Practical demonstration on a simple DC motor proved providential using this method for the two motions of an actual human arm. EMG Signals emanating from muscles dedicated to individual fingers have been recorded. Moreover modern classifiers; KNN and NN have been investigated carefully with selected features through different time and noise levels.

Three-Dimensional Magnetic Induction Tomography: Practical Implementation for Imaging throughout the Depth of a Low Conductive and Voluminous Body

Magnetic induction tomography (MIT) is a contactless, low-energy method used to visualize the conductivity distribution inside a body under examination. A particularly demanding task is the three-dimensional (3D) imaging of voluminous bodies in the biomedical impedance regime. While successful MIT simulations have been reported for this regime, practical demonstration over the entire depth of weakly conductive bodies is technically difficult and has not yet been reported, particularly in terms of more realistic requirements. Poor sensitivity in the central regions critically affects the measurements. However, a recently simulated MIT scanner with a sinusoidal excitation field topology promises improved sensitivity (>20 dB) from the interior. On this basis, a large and fast 3D MIT scanner was practically realized in this study. Close agreement between theoretical forward calculations and experimental measurements underline the technical performance of the sensor system, and the previously only simulated progress is hereby confirmed. This allows 3D reconstructions from practical measurements to be presented over the entire depth of a voluminous body phantom with tissue-like conductivity and dimensions similar to a human torso. This feasibility demonstration takes MIT a step further toward the quick 3D mapping of a low conductive and voluminous object, for example, for rapid, harmless and contactless thorax or lung diagnostics.

Extended Goal Recognition: Lessons from Magic

The “science of magic” has lately emerged as a new field of study, providing valuable insights into the nature of human perception and cognition. While most of us think of magic as being all about deception and perceptual “tricks”, the craft—as documented by psychologists and professional magicians—provides a rare practical demonstration and understanding of goal recognition. For the purposes of human-aware planning, goal recognition involves predicting what a human observer is most likely to understand from a sequence of actions. Magicians perform sequences of actions with keen awareness of what an audience will understand from them and—in order to subvert it—the ability to predict precisely what an observer’s expectation is most likely to be. Magicians can do this without needing to know any personal details about their audience and without making any significant modification to their routine from one performance to the next. That is, the actions they perform are reliably interpreted by any human observer in such a way that particular (albeit erroneous) goals are predicted every time. This is achievable because people’s perception, cognition and sense-making are predictably fallible. Moreover, in the context of magic, the principles underlying human fallibility are not only well-articulated but empirically proven. In recent work we demonstrated how aspects of human cognition could be incorporated into a standard model of goal recognition, showing that—even though phenomena may be “fully observable” in that nothing prevents them from being observed—not all are noticed, not all are encoded or remembered, and few are remembered indefinitely. In the current article, we revisit those findings from a different angle. We first explore established principles from the science of magic, then recontextualise and build on our model of extended goal recognition in the context of those principles. While our extensions relate primarily to observations, this work extends and explains the definitions, showing how incidental (and apparently incidental) behaviours may significantly influence human memory and belief. We conclude by discussing additional ways in which magic can inform models of goal recognition and the light that this sheds on the persistence of conspiracy theories in the face of compelling contradictory evidence.

The cost of corruption and undue private benefit: two hidden faces of the same mirror

Purpose The purpose of this study is to formulate the cost of corruption and undue private benefit. Design/methodology/approach The design is based on cost formulas of the corruption already formulated, and the design of these formulas allows the calculation for Argentina in 2021 of the cost of the corruption. Findings The corruption cost models for bribes and cost overruns for public works are the theoretical basis for obtaining the undue private benefit. Based on the formulas developed to calculate the costs of corruption for Argentina 2021. Research limitations/implications There are no limitations in the model. Practical implications In addition to the calculation of the cost of corruption, the formula of private profit undue by corruption is developed. Social implications The social implications are certainty about the cost of corruption for Argentina in 2021. Originality/value The present work is original and its value is given by the formulation and practical demonstration of the cost of corruption for Argentina in 2021 and the undue private benefit.

Computer based virtual laboratory simulations: LabHEART cardiac physiology practical

Practical demonstration of cardiomyocyte function requires substantial preparation, a source of freshly isolated animal hearts and specialized equipment. Even where such resources are available, it is not conducive for demonstration to any more than a few students at a time. These approaches are also not consistent with the 3R principle (replacement, reduction and refinement) of ethical use of animals. We present an implementation of the LabHEART software, developed by Donald Bers and Jose Puglisi, for medical students. Prior to the activity, students had lectures covering the physiological and pharmacological aspects of cardiac excitation-contraction (EC) coupling. We used this problem-based activity to help students consolidate their knowledge and to allow a hands-on approach to explore the key features of EC coupling. Students simulate and measure action potentials, intracellular calcium changes and cardiomyocyte contraction. They also apply drugs which target ion channels (e.g. nifedipine or tetrodotoxin), or sympathetic input (using isoproterenol) and explore changes to EC coupling. Furthermore, by modifying the biophysical parameters of key ion channels involved in the electrical activity of the heart, students also explore the effect of channelopathies such as long QT syndromes. We describe approaches to implement this activity in a flipped classroom format, with recorded lecture materials provided ahead of the practical to facilitate active learning. We also describe our experiences implementing this activity online. The content and difficulty of the activity can be altered to suit individual courses, and is also amenable to promote peer-driven learning.