Invitro Antimicrobial and Antioxidant Activities of Salvadora persica (Meswak) Roots, Leaves and Stems Extracts

As microorganisms have developed the inherent ability to develop and adopt a mechanism of resistance against antibiotic. The harmful side effect of antibiotic including their cost of drug development have slowly shifted toward the plant derived phytochemical based medicines. Screening of antimicrobial property of medicinal plants S. persica gives a positive result against the different species of bacteria (S. aureus, P. aeruginosa) and fungi (A.niger, Fusarium). Firstly, a study of phytochemicals shows that the important part to prevent and protect the plant against the microorganisms. Secondly, the importance of phytochemicals of S.perica provide the information about the compound which are responsible for the antimicrobial activity like alkaloids, phenolics, flavonoids etc. Finally, an antioxidant activity involves in the prevention of plant cell tissue damage. Antioxidant activity is measured by DPPH. The total phenolics content of this plant was good and there for this, has high antimicrobial activity. The S.persica has many applications in mouth associated problems, useful to produce antiplaque, analgesic, anticonvulsant, antimycotic, cytotoxic, antifertility, deobstruent, carminative, diuretic, and also applicable in rheumatism.

Tachycardia during Treatment with Risperidone and Paliperidone Palmitate in a Patient without Previous Cardiovascular Disease

Here, we present the case of a patient who initiated risperidone and developed persistent tachycardia, which was exacerbated by subsequent administration of paliperidone palmitate despite treatment with propranolol. This patient’s experience emphasizes the need for psychiatrists to regularly monitor vital signs after risperidone/paliperidone initiation, dosage increase, or overdose to identify and appropriately manage this potentially harmful side effect. Increasing clinician awareness of this rare side effect will help protect patients with serious mental illness who regularly rely upon these medications, particularly in their long-acting injectable formulations.

Social Media Toxicity Classification Using Deep Learning: Real-World Application UK Brexit

Social media has become an essential facet of modern society, wherein people share their opinions on a wide variety of topics. Social media is quickly becoming indispensable for a majority of people, and many cases of social media addiction have been documented. Social media platforms such as Twitter have demonstrated over the years the value they provide, such as connecting people from all over the world with different backgrounds. However, they have also shown harmful side effects that can have serious consequences. One such harmful side effect of social media is the immense toxicity that can be found in various discussions. The word toxic has become synonymous with online hate speech, internet trolling, and sometimes outrage culture. In this study, we build an efficient model to detect and classify toxicity in social media from user-generated content using the Bidirectional Encoder Representations from Transformers (BERT). The BERT pre-trained model and three of its variants has been fine-tuned on a well-known labeled toxic comment dataset, Kaggle public dataset (Toxic Comment Classification Challenge). Moreover, we test the proposed models with two datasets collected from Twitter from two different periods to detect toxicity in user-generated content (tweets) using hashtages belonging to the UK Brexit. The results showed that the proposed model can efficiently classify and analyze toxic tweets.

Innovation design and experiment research on the N–N type planetary gear apparatus with small tooth number difference

The three high-performance indicators (low retrace tolerance, long life and low vibration) of N–N type planetary gear apparatus with small tooth number difference (abbrev “N–N–PGA”) are hardly achieved simultaneously until recently. At present, the root cause analysis (RCA) and TRIZ are considered to be comprehensive and systematic new theories for technological innovation, which provides a new way to figure out the conundrum existed in the N–N–PGA. In the present study, the “root cause” of the problem is proposed with the RCA approach and two contradictions existed in the N–N–PGA have been revealed: Harmful side effect and stability of composition; harmful side effect and durability of a moving object. Besides, two reasonable principles (“Dynamicity” and “Composite materials”) for the N–N–PGA design recommended by the TRIZ method are used to eliminate these contradictions. In addition, a prototype of the obtained new type N–N–PGA design is developed for experimental testing. The obtained result demonstrates the capability of the above method for obtaining low retrace tolerance, long life, and low vibration.

Laser phototherapy as a treatment for radiotherapy-induced oral mucositis

Oral mucositis is a harmful side effect of radiotherapy (RT) on the head and neck region. There are encouraging reports on the beneficial aspects of the use of laser light on the treatment of oral mucositis. This paper reports the efficacy of laser phototherapy (LPT) on the treatment of oral mucositis in a patient undergoing RT after surgical removal of a squamous cell carcinoma with osseous invasion of the maxilla. Palatal and commissural lesions were treated with λ660 nm, 40 mW, ∅=4 mm², in contact mode, 5 x 2.4 J/cm² per point, 14.4 J/cm² per session. For treating the lesion on the patient's nasal mucosa, LPT (∅=4 mm², λ780 nm, 70 mW, 3 x 2.1 J/cm² per point, 6.3 J/cm² per session, contact mode) was used on the external area of the nose. A single dose (2.4 J/cm²) with the λ660 nm laser, as described before, was applied on the entrance of each nostril. LPT was used 3 times/week during 4 weeks. Treatment results indicate that the use of LPT on oral mucositis was effective and allowed the patient to carry on the RT without interruption. However, long-term and controlled clinical trials are necessary to establish both preventive and curative protocols using LPT.

Osteonecrosis of the Jaw Correlated to Bisphosphonate Therapy in Non-oncologic Patients: Clinicopathological Features of 24 Patients

Objective.Osteonecrosis of the jaws (ONJ) is a well known side effect of bisphosphonate therapies in patients with multiple myeloma or other malignancies. Its real incidence is still undetermined, and only few cases of ONJ in patients taking bisphosphonates for non-oncologic diseases have been reported. It was postulated that the clinical features, predisposing factors, and treatment outcome of this subset of patients might be different from those of oncologic patients.Methods.Over a 4 year period, a total of 102 bisphosphonate-treated patients affected by ONJ were identified. Among these, 24 patients underwent bisphosphonate therapy for non-neoplastic disease and their profile was analyzed.Results.In this study cohort, bisphosphonates had been administered mainly for postmenopausal osteoporosis (20/24 patients, 83.3%), the duration of therapy until presentation of ONJ ranging from 11 to 40 months and the most common triggering event being dentoalveolar surgery. All patients were nonsmokers; 6 manifested multiple ONJ lesions and only 3 of them had possible comorbidities. Surgical debridement was performed in 19 patients for a total of 22 lesions, which were individually considered in the followup. The latter showed complete remission of ONJ in 21/22 lesions.Conclusion.Although it might be considered a rare condition in non-oncologic patients, ONJ is a harmful side effect of bisphosphonate therapies. Clinicians must be aware of this entity, inform patients of the risks related to dental surgery, and possibly undertake adequate preventive measures.

Impact of Motor Vehicle Injury in Taiwan Using Potential Productive Years of Life Lost

Motor vehicle injuries are a major harmful side effect of industralization. We examine this relationship in a rapidly industrializing country, Taiwan, using Potential Productive Years of Life Lost (PPYLL) analysis, and suggest ways that the injury toll of industrialization might be mitigated. We also compare Taiwan to the US, Hungary, Korea, and Chile. Taiwan has a higher PPYLL per 100, 000 population due to motor vehicle injury (530/100, 000) than cardiac disease, cancer, or strokes. Twenty-five years ago, more PPYLL was due to cancer, strokes, cardiac disease, and tuberculosis than to motor vehicle injuries (106/100, 000). Taiwan's PPYLL rate is much greater than three other industrializing countries-Chile, Korea, and Hungary-and twice that of the US. Explanations for the dramatic rise in motor vehicle injury deaths in Taiwan may be high use of motorcycles, lack of motorcycle helmets, increase in alcohol use, high car density, and road and vehicle safety design problems.