As microorganisms have developed the inherent ability to develop and adopt a mechanism of resistance against antibiotic. The harmful side effect of antibiotic including their cost of drug development have slowly shifted toward the plant derived phytochemical based medicines. Screening of antimicrobial property of medicinal plants S. persica gives a positive result against the different species of bacteria (S. aureus, P. aeruginosa) and fungi (A.niger, Fusarium). Firstly, a study of phytochemicals shows that the important part to prevent and protect the plant against the microorganisms. Secondly, the importance of phytochemicals of S.perica provide the information about the compound which are responsible for the antimicrobial activity like alkaloids, phenolics, flavonoids etc. Finally, an antioxidant activity involves in the prevention of plant cell tissue damage. Antioxidant activity is measured by DPPH. The total phenolics content of this plant was good and there for this, has high antimicrobial activity. The S.persica has many applications in mouth associated problems, useful to produce antiplaque, analgesic, anticonvulsant, antimycotic, cytotoxic, antifertility, deobstruent, carminative, diuretic, and also applicable in rheumatism.