Computational Intelligence-Based Prognosis for Hybrid Mechatronic System Using Improved Wiener Process

In this article, a fast krill herd algorithm is developed for prognosis of hybrid mechatronic system using the improved Wiener degradation process. First, the diagnostic hybrid bond graph is used to model the hybrid mechatronic system and derive global analytical redundancy relations. Based on the global analytical redundancy relations, the fault signature matrix and mode change signature matrix for fault and mode change isolation can be obtained. Second, in order to determine the true faults from the suspected fault candidates after fault isolation, a fault estimation method based on adaptive square root cubature Kalman filter is proposed when the noise distributions are unknown. Then, the improved Wiener process incorporating nonlinear term is developed to build the degradation model of incipient fault based on the fault estimation results. For prognosis, the fast krill herd algorithm is proposed to estimate unknown degradation model coefficients. After that, the probability density function of remaining useful life is derived using the identified degradation model. Finally, the proposed methods are validated by simulations.

A novel method for predicting cell abundance based on single-cell RNA-seq data

Background It is important to understand the composition of cell type and its proportion in intact tissues, as changes in certain cell types are the underlying cause of disease in humans. Although compositions of cell type and ratios can be obtained by single-cell sequencing, single-cell sequencing is currently expensive and cannot be applied in clinical studies involving a large number of subjects. Therefore, it is useful to apply the bulk RNA-Seq dataset and the single-cell RNA dataset to deconvolute and obtain the cell type composition in the tissue. Results By analyzing the existing cell population prediction methods, we found that most of the existing methods need the cell-type-specific gene expression profile as the input of the signature matrix. However, in real applications, it is not always possible to find an available signature matrix. To solve this problem, we proposed a novel method, named DCap, to predict cell abundance. DCap is a deconvolution method based on non-negative least squares. DCap considers the weight resulting from measurement noise of bulk RNA-seq and calculation error of single-cell RNA-seq data, during the calculation process of non-negative least squares and performs the weighted iterative calculation based on least squares. By weighting the bulk tissue gene expression matrix and single-cell gene expression matrix, DCap minimizes the measurement error of bulk RNA-Seq and also reduces errors resulting from differences in the number of expressed genes in the same type of cells in different samples. Evaluation test shows that DCap performs better in cell type abundance prediction than existing methods. Conclusion DCap solves the deconvolution problem using weighted non-negative least squares to predict cell type abundance in tissues. DCap has better prediction results and does not need to prepare a signature matrix that gives the cell-type-specific gene expression profile in advance. By using DCap, we can better study the changes in cell proportion in diseased tissues and provide more information on the follow-up treatment of diseases.

Sparse Signature Matrix Optimization for NOMA under Imperfect CSI

Non-orthogonal multiple access (NOMA) can support the rapid development of the Internet of Things (IoT) with its potential to support high spectral efficiency and massive connectivity. The low-density superposition modulation (LDSM) scheme is one of the NOMA schemes and uses the sparse signature matrix to reduce multiple access interferences (MAI). In order to improve the NOMA system performance in practice, this paper focuses on designing the sparse signature matrix with a large girth for LDSM under imperfect channel state information (CSI). Based on the orthogonal pilot and linear minimum mean square error (LMMSE) estimation, the LDSM optimized by bare-bone particle swarm optimization (BBPSO) algorithm has a larger girth and can gather more accurate information in the process of iterative decoding convergence. An extrinsic information transfer (EXIT) chart analysis is designed for the LDSM-OFDM system as a theoretical analysis tool. The simulation results show that the optimized LDSM outperforms the reference LDSM system, bringing about a 0.5 dB performance gain.

Dimensionality reduction using singular vectors

A common problem in machine learning and pattern recognition is the process of identifying the most relevant features, specifically in dealing with high-dimensional datasets in bioinformatics. In this paper, we propose a new feature selection method, called Singular-Vectors Feature Selection (SVFS). Let $$D= [A \mid \mathbf {b}]$$ D = [ A ∣ b ] be a labeled dataset, where $$\mathbf {b}$$ b is the class label and features (attributes) are columns of matrix A. We show that the signature matrix $$S_A=I-A^{\dagger }A$$ S A = I - A † A can be used to partition the columns of A into clusters so that columns in a cluster correlate only with the columns in the same cluster. In the first step, SVFS uses the signature matrix $$S_D$$ S D of D to find the cluster that contains $$\mathbf {b}$$ b . We reduce the size of A by discarding features in the other clusters as irrelevant features. In the next step, SVFS uses the signature matrix $$S_A$$ S A of reduced A to partition the remaining features into clusters and choose the most important features from each cluster. Even though SVFS works perfectly on synthetic datasets, comprehensive experiments on real world benchmark and genomic datasets shows that SVFS exhibits overall superior performance compared to the state-of-the-art feature selection methods in terms of accuracy, running time, and memory usage. A Python implementation of SVFS along with the datasets used in this paper are available at https://github.com/Majid1292/SVFS.

Model-Based Diagnosis of Telecommunication Cooling Systems Malfunctioning

A model is developed that allows simulating the most-likely failures possibly occurring in freecooling (FC) systems of telecommunication (TLC) switching rooms. Main aim is to provide an effective and online implementable diagnosis method, which in turn will allow fulfilling the threefold function of safeguarding electronic equipment, ensuring desired air quality in case of human presence and reducing malfunction-related waste of energy. Specifically in this work, obstruction (reduction of the volumetric flow of air introduced into the room) and loss of efficiency (degradation of the fan) are deepened. Two black-box sub-models were developed to simulate the above described faulty functioning of the free-coolers. Subsequently, the fault signature matrix was developed, through which the “symptoms”, calculated as residuals between the “faulty” and “non faulty” conditions of the monitored variables, are associated to the corresponding faults. The peculiarity of the telecommunication sector, where nowadays data acquisition and monitoring platforms are significantly spreading to monitor most significant energy consumptions, including cooling loads, was proved essential in guaranteeing effective isolation of different faults. The simulation results highlight the reliability of the developed diagnostic tool, expected to be versatile and easy to implement enough for being extended to air-handling unit diagnosis, as well as other industrial sectors.

A review of digital cytometry methods: estimating the relative abundance of cell types in a bulk of cells

Due to the high cost of flow and mass cytometry, there has been a recent surge in the development of computational methods for estimating the relative distributions of cell types from the gene expression profile of a bulk of cells. Here, we review the five common ‘digital cytometry’ methods: deconvolution of RNA-Seq, cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT), CIBERSORTx, single sample gene set enrichment analysis and single-sample scoring of molecular phenotypes deconvolution method. The results show that CIBERSORTx B-mode, which uses batch correction to adjust the gene expression profile of the bulk of cells (‘mixture data’) to eliminate possible cross-platform variations between the mixture data and the gene expression data of single cells (‘signature matrix’), outperforms other methods, especially when signature matrix and mixture data come from different platforms. However, in our tests, CIBERSORTx S-mode, which uses batch correction for adjusting the signature matrix instead of mixture data, did not perform better than the original CIBERSORT method, which does not use any batch correction method. This result suggests the need for further investigations into how to utilize batch correction in deconvolution methods.

An Energy Graph-Based Approach to Fault Diagnosis of a Transcritical CO2 Heat Pump

The objective of this paper is to describe an energy-based approach to visualize, identify, and monitor faults that may occur in a water-to-water transcritical CO 2 heat pump system. A representation using energy attributes allows the abstraction of all physical phenomena present during operation into a compact and easily interpretable form. The use of a linear graph representation, with heat pump components represented as nodes and energy interactions as links, is investigated. Node signature matrices are used to present the energy information in a compact mathematical form. The resulting node signature matrix is referred to as an attributed graph and is populated in such a way as to retain the structural information, i.e., where the attribute points to in the physical system. To generate the energy and exergy information for the compilation of the attributed graphs, a descriptive thermal–fluid model of the heat pump system is developed. The thermal–fluid model is based on the specifications of and validated to the actual behavioral characteristics of a physical transcritical CO 2 heat pump test facility. As a first step to graph-matching, cost matrices are generated to represent a characteristic residual between a normal system node signature matrix and a faulty system node signature matrix. The variation in the eigenvalues and eigenvectors of the characteristic cost matrices from normal conditions to a fault condition was used for fault characterization. Three faults, namely refrigerant leakage, compressor failure and gas cooler fouling, were considered. The paper only aims to introduce an approach, with the scope limited to illustration at one operating point and considers only three relatively large faults. The results of the proposed method show promise and warrant further work to evaluate its sensitivity and robustness for small faults.

Progressive Multiple Sclerosis Transcriptome Deconvolution Indicates Increased M2 Macrophages in Inactive Lesions

Accumulating evidence suggests M2 macrophages contribute to tissue reparation and limit inflammation in multiple sclerosis (MS). However, most studies have focused on murine models without substantial support through human MS observations. The present study aimed to quantify the relative abundances of M2 macrophages in different lesion types excised from human MS patients. CIBERSORTx, an established RNA deconvolution algorithm, was applied on bulk RNA-sequencing data developed from 98 lesions from 10 progressive MS patients and 5 neuropathological control donors. A validated gene signature matrix for 22 human hematopoietic cell subsets was used to infer the relative proportions of immune cells that were present in the original lesion. Deconvolution of the bulk gene expression data showed that inactive lesions contained significantly more M2 macrophages compared to normal white matter control samples. The findings suggest that M2 macrophages may play a role during lesion inactivity in MS.