scholarly journals ПЕРФУЗІЙНА ДИСФУНКЦІЯ ПРИ ГОСТРОМУ ПАНКРЕАТИТІ: ПЕРСПЕКТИВНІ НАПРЯМКИ УДОСКОНАЛЕННЯ ДІАГНОСТИКИ ТА СТРАТИФІКАЦІЇ ЗАХВОРЮВАННЯ

2021 ◽  
Vol 25 (5-6) ◽  
pp. 12-15
Author(s):  
Н.Р. Кербаж ◽  
С.І. Панасенко

Introduction. Acute pancreatitis (AP) is one of the most common diseases of the digestive system that require hospitalization. To date, the problem of stratification and differential diagnosis of AP in the early stages remains unresolved, which encourages the search for new methods of diagnosis and prediction of the severity of AP. Aim. To evaluate the possibility of creating a clinically oriented system of stratification and prognosis of AP on the basis of dynamic changes in microcirculation depending on the duration of the disease and severity of AP. Materials and methods. Assessment of the state of microcirculation (MC) of patients by laser Doppler flowmetry (LDF) was performed with the “LAKK-02” device. Kruskal-Wallis non-parametric analysis of variance and the median test were used to test statistical hypotheses when comparing independent samples. Pairwise comparison of independent samples was performed using the Mann-Whitney U test. Results. The study determined the indicators of MC in patients with different AP severity degrees on the first day of the disease. The microcirculation parameter (MP) in patients with mild, moderate, and severe AP was 3.9; 3.8 and 6.8 perfusion units (p.u.), respectively. The blood flow modulation rate (ơ) was 0.52; 0.54 and 0.69 p.u. in mild, moderate, and severe AP. In our study, the coefficient of variation (Kv) averaged 17.3%; 20.0% and 11.7% in patients with mild, moderate, and severe AP, respectively. Conclusions. LDF in AP is an informative method of diagnosing the state of MC, which is a universal link in all pathophysiological reactions of the organism. Changes of MC in AP depend on the severity of AP and the period of the disease. The pathophysiological microcirculatory phenomena, revealed on the first day of the disease, provide us with the perspectives of early clinical distinguishing the moderate and severe forms of AP from the so-called group of “destructive forms”.

2017 ◽  
Vol 16 (4) ◽  
pp. 60-64
Author(s):  
A. A. Blazhko ◽  
I. I. Shakhmatov ◽  
V. I. Kiselev ◽  
N. A. Lycheva ◽  
S. V. Moskalenko

Introduction. A considerable physical load can lead to the damage of various organs and systems including the system of the microcirculatory bloodstream. Materials and methods. The experimental groups of animals were exposed to 4-hour and 8-hour physical load. The state of the microcirculatory bloodstream was examined by means of laser Doppler flowmetry. Results. 4-hour physical load did not cause any reduction of the microcirculation parameter in rats. 8-hour physical load led to a decrease of the microcirculation parameter and further reduction of flux parameter. Conclusions. Such changes of microcirculation parameters can be one of the symptoms of development of the state of thrombotic readiness and high risk of thrombosis in rats after 8-hour physical load.


1974 ◽  
Vol 35 (2) ◽  
pp. 979-985 ◽  
Author(s):  
John Mahoney

The present study investigated Maslow's assertion that there exists a cluster of values characteristic of self-actualizing persons. A total of 84 college students, 35 male and 49 female, completed the Personal Orientation Inventory and the Rokeach Value Survey. Based on the former profile, Ss were designated as reflecting one of 4 levels of self-actualization. Differential rank ordering of each value for the four groups was assessed via extensions of the median test. Results lend partial support to Maslow's assertion. The value of “social recognition” was negatively correlated with self-actualization. Significant recursive rankings in which self-actualizing persons ranked values similarly to severely nonactualizing persons but unlike normal individuals were observed for “a comfortable life,” and “a world at peace.” Findings were interpreted in terms of the self-actualizing person's definition of values and his perception of realistic limitations on his abilities.


2011 ◽  
Vol 2011 ◽  
pp. 1-8
Author(s):  
Han-Wei Huang ◽  
I-Ming Jou ◽  
Chien-Kuo Wang ◽  
Pei-Yin Chen ◽  
Wen-Chi Wang ◽  
...  

The main purpose of this study was to investigate the applicability of frequency domain analysis on laser Doppler flowmetry (LDF) data recorded from the index fingers of patients with carpal tunnel syndrome (CTS) and diabetic polyneuropathy (DPN). Patients with numbness of the palm were recruited and grouped according to the results of electrophysiological examinations into 2×2 groups by the existence or nonexistence of CTS and/or DPN. Skin blood perfusion was recorded by LDF in both the neutral position and the maximally flexed position (the Phalen test). -transformation was utilized to decompose the recorded data into frequency bands, and the relative band power and power dispersion were calculated. Analysis of variance was used to test the effects of DPN, CTS, and the Phalen test results. The results showed that (1) DPN decreased the absolute power and the relative power in some frequency bands in both positions and CTS increased the power dispersion of some frequency bands only during the Phalen test and (2) there was no difference in the LDF results between patients with positive or negative Phalen test results.


Author(s):  
Mehernosh Irani ◽  
Lyle Finn

The state-of-the art in model testing for Vortex Induced Vibrations (VIV) of Spars is presented. Important issues related to Spar VIV model testing are highlighted. The parameters that need to be modeled including hull geometry, strake configuration, mass and mooring properties and, considerations of test set-up and instrumentation are discussed. Results are presented from model tests of an as-built Spar deployed in the Gulf of Mexico. It is shown that the model test results compare well with the VIV responses measured in the field.


2016 ◽  
Vol 23 (3) ◽  
Author(s):  
O. V. Spahiu ◽  
A. P. Paholchuk

Treatment of infected and septic wounds remains one of the most important problems of pediatric surgery. According to the authors, the wound process monitoring affects the treatment outcome not less than operative technique.The objective of the research was to examine the dynamics of microcirculation of the infected and septic wounds in children.Materials and methods. The analysis of the study of infected and septic wounds microcirculation in 178 children was performed. Blood flow laser analyzer (“LAKК-02” RPE “Lazma”, Russia) was used to study the blood flow in the wound area. Monitoring of wound healing process dynamics was conducted by studying the wound healing cytogram.Results. On the first day the average parameter of microcirculation was markedly increased in the area of wound edges in comparison with the contralateral area. The subsequent study of a blood flow during 5 days showed that average value of microcirculation parameter in the wound area decreased by more than 2 times in comparison with the figures on the first day. Microcirculation parameters of in the wound area further decreased.Conclusions. Dynamics of microcirculation changes in wound healing process significantly corresponds to cytogram of impression smears obtained from infected and septic wounds in children. Laser Doppler flowmetry is an effective method microcirculation control and minimally invasive diagnostic method of wound healing process.


Author(s):  
Хамди Кхаем ◽  
Елена Гортинская

A laser Doppler flowmetry study of the state of the micro­vasculature of the skin in patients with rosacea was per­formed. The amplitude-frequency criteria for assessing dermal circulation are determined. Depth and direction of vascularization disorders are shown. It is proved that the amplitude-frequency characteristic of the state of the micro­vasculature of the skin should be taken into account when choosing the means of therapeutic correction and can serve as one of the criteria for the effectiveness of treatment.


2020 ◽  
Vol 101 (2) ◽  
pp. 206-211
Author(s):  
A F Hummatov ◽  
A H Abbasov ◽  
A K Ismayilov ◽  
E M Gasymov

Aim. To identify the causes affecting hypocalcemia and its frequency of causing after thyroidectomy. Methods. The study included 402 patients after thyroidectomy, 361 (89.8%) women and 41 (10.2%) men, for the period 20152019. The patients were between the ages of 14 and 77 years (average 4527.2 years). Patients were tested for the presence of hyperthyroidism, the volume of tissue removed and type of thyroidectomy, presence of repeated thyroid operations and accidental parathyroidectomy, the results of parathyroid autotransplantation and pathohistological reports. To determine the effect of these factors on hypocalcemia, patients were divided into three groups. The first group included patients (n=51, 12.7%) were underwent surgery for Graves disease, the second (n=335, 83.3%) for nodular goiter, and the third (n=16, 4%) for recurrent goiter. Statistical data analysis was performed with IBM SPSS 16.0. The results were analyzed by one-way analysis of variance or KruskalWallis test and the median test. Results were considered statistically significant at p 0.05 (two-sided criterion). Results. In the early postoperative period, 20 (5%) of 402 patients had hypocalcemia, of which 12 (3%) had transient hypocalcemia, and 8 (2%) had permanent hypocalcemia. Postoperative hypocalcemia was detected in 9 (17.6%) patients the first group, 8 (2.4%) patients in the second group, and 3 (18.8%) patients of the third group. Patients hypocalcemia was characterized based on the types of underwent operations as follows: in 14 (5.3%; p 0.05) patients after total thyroidectomy, in 1 (3.2%) patient after close to total thyroidectomy, in 1 (16.7%) patient after total thyroidectomy with central lymphatic dissection, in 1 (20%) patient after total thyroidectomy with central and lateral lymphatic dissection, in 3 (18.8%) patients after repeated surgery. Postoperative hypocalcemia was identified in 5 of 44 patients of the second group with thyroid carcinoma, as well as in 1 patient of the third group with the same pathology (p=0.246). Conclusion. Incidence of hypocalcemia was more frequent after surgery for hyperthyroidism, especially after total thyroidectomy; in 40% of cases, transient hypocalcemia was identified in patients with autotransplantation of the parathyroid gland after an accidental parathyroidectomy.


2021 ◽  
Vol 20 (3) ◽  
pp. 46-53
Author(s):  
V. I. Kozlov ◽  
V. N. Sakharov ◽  
O. A. Gurova ◽  
V. V. Sidorov

Introduction. The state of the blood flow within the capillaries and close blood vessels is highly important in practice for the revealing of pathogenetic mechanisms of both systemic and local circulatory disorders. Aim of the study was to define the parameters of microcirculation and the level of blood flow fluctuations (flux) in the distal segments of upper and lower limbs (in fingers of hands and toes of feet) in children of 6–7 years old; and to describe the possible differences in the mechanisms of blood flow modulation in boys and girls. Materials and methods. Skin microcirculation was assessed in middle fingers of hands and great toes of feet in children of 6-7 years old (14 girls and 7 boys in prone position) by means of laser doppler flowmetry. Results. The ranges for parameters of microcirculation (PM) for distal segments of upper and lower limbs in children of mentioned age group were defined, also it was shown that the PM are significantly lower in the lower limbs comparing to those of the upper limbs (both in groups of girls and boys). Asymmetry of PM in the feet was not found; the features of right hand-left hand asymmetry for PM in girls and boys are described. The analysis of modulation of blood flow fluctuations (fluxmotions) of different frequencies showed the profound role of vasomotor (myogenic) rhythm for regulation of microcirculation. Conclusion. Increased neurogenic influences on the modulation of fluxmotions in girls of 6-7 years old may be an evidence of the ongoing development of the mechanisms of blood flow regulation, particularly the association with the growth rate of girls is possible.


Author(s):  
Tetana Stanishevska ◽  
Оksana Gorna ◽  
Daria Horban ◽  
Olga Yusupova

This research deals with the study of blood microcirculation peculiarities.Materials and methods. 72 students of Bogdan Khmelnytsky Melitopol State Pedagogical University, aged 18–19, were examined. The experimental research consisted of the study of blood microcirculation functional state by means of Laser Doppler flowmetry (LDF) method. It helped to evaluate the state of tissue blood-circulation and to detect individual-typological peculiarities of blood microcirculation under the influence of physical activity (before and after exercise).Results. Three types of blood microcirculation were identified by using LDF-metry. The normoemic type of blood microcirculation, characterized by the superposition of oscillatory rhythms and reflected the balance of the mechanisms of regulation of microcirculation. The hyperemic type, characterized by a «monotonous» LDF-gram with a high parameter of microcirculation, which reflects the relative predominance of metabolic mechanisms in the regulation of microcirculation. The hypoemic type, characterized by a «monotonous» LDF-gram with a low parameter of the microcirculation parameter, which reflects the decrease of vasomotor mechanisms in the regulation of microcirculation. According to the LDF-metric data, the examined students under intensive physical activity have a significant increase in microcirculatory status: by 6 % of the microcirculation parameter, by 28 % of the mean square deviation and by 45 % of the initial value of the coefficient of variation.Conclusions. This dynamics of microcirculation shows that under the influence of physical exertion, a person creates significant functional reserves for the redistribution of blood flow and for more perfect intraorgan capillary blood flow. It was found, that in the process of physical activity, morpho-functional rearrangements of the human cardiovascular system occur. This reaction is formed by several components of blood microcirculation: blood flow in the transport direction, regulating blood supply in accordance with the needs of tissues and the exchange component of the histochemical barrier


2014 ◽  
Vol 13 (2) ◽  
pp. 099-108
Author(s):  
Józef Jasiczak ◽  
Marcin Kanoniczak ◽  
Łukasz Smaga

The article presents the division of test results series for the compressive strength of concrete into concrete families for the continuous production of concrete mix used for the manufacture of precast concrete slabs in Spiroll technology. On the basis of a calculation procedure involving the verification of assumed statistical hypotheses, the division of a set of concrete strength results achieved after 1 and 28 days of curing was made. Concrete families were obtained representing the statistical invariability of strength parameters for the concrete manufactured in a defined period of time.


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