This chapter is concerned with interactivity of information representations in e-learning environments (ELEs)—where interactivity refers to the quality or condition of interaction with representations in an ELE. An ELE is any interactive computer-based software that mediates and supports learners’ engagement with information. This chapter draws upon literature from the areas of human-information interaction, distributed cognition, and learning sciences with the goal of developing and exploring the features of a preliminary framework for thinking about interactivity in the context of ELEs. In this chapter we provide some background and motivation for such a framework, and identify and elaborate upon 10 structural elements of interaction that affect the interactivity of information representations: actual affordances and constraints, articulation mode, control, event granularity, focus, action flow, reaction flow, propagation, transition, and perceived affordances and constraints. Each of these has an effect on the learning and cognitive processes of learners, and the overall interactivity of an ELE is an emergent property of a combination of these elements. Collectively, these elements can serve as a framework to help thinking about design and analysis of interactivity in ELEs.