Although most individuals recover from concussion within 7 to 10 days, a sizable minority have prolonged concussion symptoms, especially those who also suffered loss of consciousness, post-traumatic amnesia, many acute symptoms, and immediate dizziness. Thus, someone could remain symptomatic from concussion more than two weeks following the injury. At that point, however, the discerning clinician must differentiate prolonged concussion symptoms from the evolution of persistent symptoms from comorbid neurologic conditions or emerging mental health symptoms or disorders. Too often, prolonged or persistent symptoms are not considered in the context of initial concussion injury and symptoms, proper return to activity, or emerging comorbid conditions that can also lead to persistent symptoms.